Effects of pharmacological treatment on metabolomic alterations in animal models of depression

Pu, Juncai; Liu, Yiyun; Gui, Siwen; Tian, Lu; Yu, Yue; Wang, Dongfang; Zhong, Xiaogang; Chen, Weiyi; Chen, Xiaopeng; Chen, Yue; Chen, Xiang; Gong, Xue; Liu, Lanxiang; Li, Wenxia; Wang, Haiyang; Xie, Peng

doi:10.1038/s41398-022-01947-5

Cited by 30 publications

(10 citation statements)

References 70 publications

(67 reference statements)

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“…The effects of CUMS, HCW and HCE on the composition and function of the intestinal flora were analyzed via 16S rRNA sequencing. The community composition was analyzed to obtain the abundance and diversity of each species ( Pu et al, 2022 ). At the phylum level, Firmicutes , Bacteroidetes , and Proteobacteria were predominant in all samples but varied in their abundances ( Figure 7A ).…”

Section: Resultsmentioning

confidence: 99%

Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts

et al. 2022

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Hemerocallis citrina Baroni [Asphodelaceae], which is traditional herbal medicine, has been widely used for treating depressive disorders in Eastern-Asia countries. However, the active compounds and corresponding mechanism of anti-depression are not yet completely clarified. In this study, the anti-depressive activities of six H. citrina extracts were primarily evaluated. The results showed that the water extract of H. citrina flowers (HCW) displays significant anti-depressive activity. A total of 32 metabolites were identified from HCW by high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) and nuclear magnetic resonance (NMR). And then, the anti-depressive activity of the high-level compound (rutin) in HCW was also estimated. The results indicated that rutin displayed significant anti-depressive activity and was one of the main active ingredients. Finally, the anti-depressive mechanisms of HCW and rutin were investigated based on the intestinal microorganisms. The results showed that HCW and rutin increase the diversity and richness of the intestinal flora and regulate the specific intestinal microorganisms such as Bacteroides and Desulfovibrio genera in depressed mice. This work marks the first comprehensive study of the active components, anti-depressive activities and corresponding mechanisms of different H. citrina extracts, which provide a potential possibility for developing new antidepressants.

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Section: Resultsmentioning

confidence: 99%

Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts

et al. 2022

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“…Previous studies have shown that 5-HIAA can be decomposed by serotonin intracellular monoamine oxidase (MAO), and both metabolites are closely related to depression and are expressed at low levels in patients with depression [67,68]. In addition, cortisol plays several key roles in promoting homeostasis, including regulating and suppressing healthy stress responses [69].…”

Section: Plos Onementioning

confidence: 99%

Whole genome sequence analysis of two subspecies of Companilactobacillus Futsaii and experimental verification of drug resistance and effect on the exploratory behavior of mice based on unique gene

Zhao

Wang²,

Jiao

et al. 2022

PLoS ONE

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This study characterized the whole genome of Companilactobacillus futsaii subsp. chongqingii CQ16Z1 isolated from Chongqing of China, performed genome sequence analysis with Companilactobacillus futsaii subsp. futsaii YM0097 isolated from Taiwan of China, and experimentally verified drug resistance and effect on the exploratory behavior of male C57BL/6 mice and analysis of gut microbiota and metabolomic studies. The genome of CQ16Z1 is 2.6 Mb. Sequence analysis between genomes showed that the two strains are Companilactobacillus futsaii. The unique genes of CQ16Z1 and YM0097 are 217 and 267, which account for 9% and 11% of the whole genomes, respectively. According to unique gene annotation, the results showed that genes associated with carbohydrate metabolism, environmental information processing, metabolism of cofactors and vitamins, cell wall/membrane/envelope biogenesis, phage and drug resistance are significantly different. The results of the drug resistance experiment showed that YM0097 had different degrees of resistance to 13 antibiotics, while CQ16Z1 was sensitive to more than half of them. YM0097 contains 9 prophage regions and CQ16Z1 contains 3 prophage regions. The results of the open field test showed that the time (P = 0.005; P = 0.047) and distance (P < 0.010; P = 0.046) of the central area of Y97 group and CQ group are significantly different from the control group. The results of the elevated plus maze test showed that compared with the control group, Y97 group had significant differences in the number of entries to the open arms and the percentage of open arms entry times (P = 0.004; P = 0.025), while the difference between the CQ group and the control group was not significant. YM0097 has a more obvious effect on the exploratory behavior of mice. The effects of YM0097 and CQ16Z1 on the intestinal flora of mice are also different. YM0097 may be more beneficial to the intestinal flora of the host. And LC/MS also showed that the metabolic effects of the two strains on the host are different. Finally, we believe that YM0097 is more suitable for application research as a psychobiotics.

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“…Similar to other studies [ 12 , 13 ], our earlier research [ 14 ] found that though there was no significant difference in high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) between the MDD patients and healthy controls (HCs), the total cholesterol (TC) and LDL-C levels were much lower in MDD compared to HCs. Meanwhile, the TC levels were positively correlated with LDL-C levels, and the reduction of TC was connected with the severity of MDD [ 9 ], suggesting that low lipid levels may play a role in the pathogenesis of MDD. In addition, the absence of a specific molecular basis for diagnosis in psychiatry at this time prevents the creation of diagnostic tools, and diagnosis in MDD is still reliant on symptomatology.…”

Section: Introductionmentioning

confidence: 99%

“…However, only 30-40% remit with antidepressant treatment leaving nearly 60-70% of patients who do not optimally respond [7]. Increased knowledge suggested that lipid abnormalities play a significant part in the pathophysiology of MDD [8][9][10][11], which may open up a new avenue for research into the underlying mechanism of MDD.…”

Section: Introductionmentioning

confidence: 99%

Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder

Xu,

Zhao,

Ren

et al. 2024

Transl Psychiatry

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The pathogenesis of major depressive disorder (MDD) involves lipid metabolism. Our earlier research also revealed that MDD patients had much lower total cholesterol (TC) concentrations than healthy controls (HCs). However, it is still unclear why TC decreased in MDD. Here, based on the Ingenuity Knowledge Base’s ingenuity pathway analysis, we found that sodium voltage-gated channel alpha subunit 11A (SCN11A) might serve as a link between low lipid levels and MDD. We analyzed the TC levels and used ELISA kits to measure the levels of SCN11A in the serum from 139 MDD patients, and 65 HCs to confirm this theory and explore the potential involvement of SCN11A in MDD. The findings revealed that TC levels were considerably lower and SCN11A levels were remarkably increased in MDD patients than those in HCs, while they were significantly reversed in drug-treatment MDD patients than in drug-naïve MDD patients. There was no significant difference in SCN11A levels among MDD patients who used single or multiple antidepressants, and selective serotonin reuptake inhibitors or other antidepressants. Pearson correlation analysis showed that the levels of TC and SCN11A were linked with the Hamilton Depression Rating Scales score. A substantial association was also found between TC and SCN11A. Moreover, a discriminative model made up of SCN11A was discovered, which produced an area under a curve of 0.9571 in the training set and 0.9357 in the testing set. Taken together, our findings indicated that SCN11A may serve as a link between low lipid levels and MDD, and showed promise as a candidate biomarker for MDD.

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Effects of pharmacological treatment on metabolomic alterations in animal models of depression

Cited by 30 publications

References 70 publications

Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts

Antidepressant-like activity, active components and related mechanism of Hemerocallis citrina Baroni extracts

Whole genome sequence analysis of two subspecies of Companilactobacillus Futsaii and experimental verification of drug resistance and effect on the exploratory behavior of mice based on unique gene

Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder

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