Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen

Aizawa, Naoki; Wyndaele, Jean‐Jacques

doi:10.1002/nau.20886

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…As expected, lidocaine blocked the relaxation effects of phenylephrine ( Fig. 2 ) because it is a sodium channel blocker that inhibits both afferent and efferent nerve activities [ 18 ]. This suggests that neurogenic activity may play a role in modulating phenylephrine-induced relaxation.…”

Section: Discussionsupporting

confidence: 55%

Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder

Chang

Hsieh

et al. 2018

Int Neurourol J

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PurposeThe urinary bladder (UB) is innervated by both sensory and autonomic nerves. Recent studies have shown that sensory neuropeptides induced contractions in the detrusor muscle. Therefore, in a mouse model, we investigated the presence of interactions between the submucosal sensory nerves and the autonomic nerves that regulate the motor function of the detrusor muscle.MethodsUB samples from male C57BL/6 mice were isolated, cut into strips, and mounted in an organ bath. Dose-response curves to norepinephrine and phenylephrine were studied in UB strips with and without mucosa, and the effects of preincubation with a receptor antagonist and various drugs on relaxation were also studied using tissue bath myography.ResultsPhenylephrine-induced relaxation of the UB strips showed concentration-related effects. This relaxation appeared in both mucosa-intact and mucosa-denuded UB strips, and was significantly inhibited by lidocaine, silodosin, and guanethidine (an adrenergic neuronal blocker). Meanwhile, phenylephrine-induced relaxation was inhibited by pretreatment with propranolol and calcitonin gene-related peptide (CGRP)–depletory capsaicin in UB strips with and without mucosa.ConclusionsThe present study suggests that phenylephrine activates the α-1A adrenergic receptor (AR) of the sensory nerve, and then activates capsaicin-sensitive sensory nerves to release an unknown substance that facilitates the release of norepinephrine from adrenergic nerves. Subsequently, norepinephrine stimulates β-ARs in the detrusor muscle in mice, leading to neurogenic relaxation of the UB. Further animal and human studies are required to prove this concept and to validate its clinical usefulness.

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Section: Discussionsupporting

confidence: 55%

Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder

Chang

Hsieh

et al. 2018

Int Neurourol J

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“…For this reason, some clinicians let patients turn to the left and right side to increase the contact area and improve the anesthetic effect. In rats, lidocaine inhibited both the Aδ-and C-fiber activities of the urinary bladder [26]. However, it is believed that small nerve fibers such as type C fibers are blocked faster as larger fibers such as Aδ.…”

Section: Discussionmentioning

confidence: 99%

Sensation of Cold during the Ice Water Test Corresponds to the Perception of Pain during Botulinum Toxin Bladder Wall Injections

Reitz

Hüsch²,

Doggweiler³

et al. 2018

Urol Int

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Aims: To investigate the association of bladder cold sensation (BCS) during the ice water test (IWT) and pain perception when botulinum toxin injections (BTI) are administered into the bladder wall. Material and Methods: In 86 patients with idiopathic overactive bladder, the BCS during the IWT was investigated. Patients were divided into 2 groups: with and without BCS. During subsequent administration of BTI, the number of perceived and painful injections as well as the pain levels on a 0-100 pain scale were compared in both groups using Student t test. Results: Thirty-five patients reported a BCS, while 51 did not. After 10 BTI, the mean number of perceived injections was 7.9 in patients with and 2.4 in patients without BCS (p < 0.0001). The mean number of painful injections was 5.4 in patients with BCS and 4.3 in patients without (p < 0.001). Mean levels on a 0-100 pain scale were 33.7 in patients with and 17.8 in patients without cold sensation (p < 0.0001). Conclusion: The association of BCS during the IWT and pain to during BTI may implicate that the perceptions of cold and pain in the urinary bladder may use similar receptors and neuronal pathways.

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“… TRPA1 mediates spinal antinociception induced by APAP and a cannabinoid. Hot plate Paw pressure Normal mice or Trpa1 –/– mice Saline Mice/M Effects of spinal/systemic APAP lost in Trpa1 –/– 300 Andersson et al 2011 141 Hot plate Paw pressure Normal mice or Trpa1 –/– mice Saline Mice/M Effects of spinal/systemic APAP lost in Trpa1 –/– 50 or 100 10 Phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and APAP Bladder primary afferent activity Normal Saline Rat/F Decreased activity 1–10 Aizawa et al 2010 92 11 Different mechanisms underlie analgesic actions of APAP and dipyrone in inflammatory pain Von Frey Normal Saline Rat/M Increased threshold Dose dependent 60–360 Rezende et al 2008 124 12. Endocannabinoid and serotonergic systems needed for APAP-induced analgesia Von Frey Hot plate Normal DMSO and saline Rat/M Increased threshold 300 …”

Section: Analgesic Efficacy Of Acetaminophen In Preclinical Modelsmentioning

confidence: 99%

Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing

Hoshijima¹,

Hunt²,

Nagasaka³

et al. 2021

JPR

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Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen

Abstract: This study shows that phenazopyridine can directly inhibit the mechanosensitive Aδ-fibers in the normal rat bladder. This finding might explain its clinical effect in conditions of bladder hypersensitivity.

Cited by 16 publications

References 27 publications

Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder

Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder

Sensation of Cold during the Ice Water Test Corresponds to the Perception of Pain during Botulinum Toxin Bladder Wall Injections

Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing

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