Effects of phenylpropanoid and iridoid glycosides on free radical-induced impairment of endothelium-dependent relaxation in rat aortic rings

Ismailoglu, Ugur B.; Saraçoğlu, İclal; Harput, Ü. Şebnem; Şahin-Erdemli, İnci

doi:10.1016/s0378-8741(01)00377-4

Cited by 52 publications

(30 citation statements)

References 12 publications

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“…[25][26][27][28] Recently some phenylethanoids have been reported to be good anti-oxidants and free radical scavengers in some in vitro assay models. [29][30][31] These free radicals play a major role in the pathogenesis of various disorders, including atherosclerosis, cancer, aging, rheumatoid arthritis and inflammation. 32) As shown in Table 2, persicoside and acteoside have potent radical scavenging activity which is more than that of 3-tert-butly-4-hydroxyanisole (BHA) and dl-a-tocopherol known as natural antioxidants.…”

Section: Resultsmentioning

confidence: 99%

Phenylethanoid and Iridoid Glycosides from Veronica persica.

Harput

Saraçoğlu

Inoue

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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In the flora of Turkey, the genus Veronica L. (Scrophulariaceae) is represented by 79 species, 26 of which are endemic.1) Some Veronica species are used as folk medicines in Turkey and in several other countries. [2][3][4][5] The genus Veronica is known to contain mainly iridoid glucosides, especially benzoic and cinnamic acid esters of catalpol, some phenylethanoid and flavonoid glycosides. [6][7][8][9][10] In previous studies, iridoid glucosides, phenylethanoid glycosides and alkaloids have been reported from Veronica persica POIRET. [11][12][13] Our previous research on this plant has demonstrated that the water soluble portion of MeOH extract has a suppressive effect on nitric oxide production in lipopolysaccharide-stimulated mouse peritoneal macrophages due to its free radical scavenging activity, and the chloroform soluble portion of MeOH extract shows cytotoxicity against KB and B16 cells.14) Continuing our studies on bioactive constituents of Veronica species, we here examine V. persica and isolate a new phenylethanoid glycoside, termed persicoside (1) together with eleven known compounds: acteoside (2), 15) isoacteoside (3), 16) lavandulifolioside (4), 17) dulcitol (5), aucubin (6), 18) veronicoside (7), 19) amphicoside (8), 20) 6-O-veratroyl-catalpol (9), 21) catalposide (10), 20) verproside (11) 22) and verminoside (12). 23) This paper describes the isolation and the structure determination of the new phenylethanoid along with its free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Dulcitol was isolated as a crystal, and therefore its structure was determined by X-ray crystallographic analysis. The structures of the other known compounds were identified by comparison of their spectral data with those reported in the literature. Results and DiscussionCompound 1 A new phenylethanoid glycoside, persicoside (1) and three known phenylethanoid glycosides, acteoside (2), isoacteoside (3) and lavandulifolioside (4)

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Section: Resultsmentioning

confidence: 99%

Phenylethanoid and Iridoid Glycosides from Veronica persica.

Harput

Saraçoğlu

Inoue

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…As far as our literature survey could ascertain, several compounds have been reported on the phytochemicals of Phlomis species evaluated here (Keser et al, 2012;Kirimer et al, 2006;Masoudi et al, 2006;Kirmizibekmez et al, 2004Kirmizibekmez et al, , 2005Ismailoglu et al, 2002;Bucar et al, 1998;Saracoglu et al, 1998).…”

Section: Phenolic Compositionmentioning

confidence: 92%

“…pungens, phenylpropanoid glycosides, forsythoside B and alyssonoside, and the iridoid glycoside lamiide have previously been isolated and characterized by Ismailoglu et al (2002). Additionally, three known phenylethanoid glycosides, forsythoside B, alyssonoside and leucosceptoside B, and a known iridoid glycoside, lamiide, were also isolated from the methanol extract of the aerial parts of P. pungens var.…”

Section: Phenolic Compositionmentioning

confidence: 99%

Phenolic content, enzyme inhibitory and antioxidative activity potentials of Phlomis nissolii and P. pungens var. pungens

Sarıkürkçü

Uren

Tepe

et al. 2014

Industrial Crops and Products

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“…Moreover, forsythoside B and alyssonoside can counteract the free radical-induced inhibition of endothelium-dependent relaxation in response to acetylcholine [227]. This protective effect can be mainly attributed to the free radical scavenging property of the PhGs.…”

Section: Effects On the Cardiovascular Systemmentioning

confidence: 97%

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Fu¹,

Pang²,

Wong

2008

CMC

136

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ABATRACTNatural products have long been regarded as excellent sources for drug discovery given their structure diversity and wide variety of biological activities. Phenylethanoid glycosides are naturally occurring compounds of plant origin and are structurally characterized with a hydroxyphenylethyl moiety to which a glucopyranose is linked through a glycosidic bond. To date several hundred compounds of this type have been isolated from medicinal plants and further pharmacological studies in vitro or in vivo have shown that these compounds possess a broad array of biological activities including antibacterial, antitumor, antiviral, anti-inflammatory, neuro-protective, antioxidant, hepatoprotective, immunomodulatory, and tyrosinase inhibitory actions. Given their extensive activity profile, structure-activity relationships analyses of these compounds have been performed in a number of studies to reveal potential leads for future drug design. This article will summarize the major developments in phenylethanoid glycosides-based research in the past decade. The progresses made in phytochemistry and biological activity studies of these compounds will be reviewed. Particular attention will be given to the novel structures identified to date and the prominent therapeutic values associated with these molecules.

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Effects of phenylpropanoid and iridoid glycosides on free radical-induced impairment of endothelium-dependent relaxation in rat aortic rings

Cited by 52 publications

References 12 publications

Phenylethanoid and Iridoid Glycosides from Veronica persica.

Phenylethanoid and Iridoid Glycosides from Veronica persica.

Phenolic content, enzyme inhibitory and antioxidative activity potentials of Phlomis nissolii and P. pungens var. pungens

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

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