1997
DOI: 10.1159/000139532
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Effects of Phenytoin on the Amygdala Neurons in vitro

Abstract: The present study was aimed at elucidating the possible mechanisms underlying the anticonvulsant efficacy of phenytoin using intracellular recording techniques in the in vitro amygdalar slice preparation. Synaptic response mediated by the N-methyl-D-aspartate (NMDA) receptor (EPSPnmda) was isolated pharmacologically by application of a solution containing non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (10 µmol/l) and γ-aminobutyric acidA receptor antagonist bicuculline (20 µmol/l)… Show more

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Cited by 3 publications
(2 citation statements)
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“…These characteristics could be credited to a state‐dependent Na + channel blocking mechanism (Rogawski & Porter, 1990) and were shared by anticonvulsant drugs such as phenytoin, carbamazepine and lamotrigine (Willow et al , 1985; Leach et al , 1986; Backus et al , 1991). However, unlike topiramate, these drugs act by more than one mechanism and inhibit synaptic responses at a low stimulation frequency (1 pulse per 20 s), an effect which is likely due to inhibition on the Ca 2+ channels (Wang et al , 1996; Stefani et al , 1996; Cheng et al , 1997). In this respect, topiramate is expected to provide a more selective therapy with fewer adverse effects, although the question of whether an absolute selectivity of a drug is desirable in seizure therapy that involves complex adaptive changes is still in doubt (Loscher, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…These characteristics could be credited to a state‐dependent Na + channel blocking mechanism (Rogawski & Porter, 1990) and were shared by anticonvulsant drugs such as phenytoin, carbamazepine and lamotrigine (Willow et al , 1985; Leach et al , 1986; Backus et al , 1991). However, unlike topiramate, these drugs act by more than one mechanism and inhibit synaptic responses at a low stimulation frequency (1 pulse per 20 s), an effect which is likely due to inhibition on the Ca 2+ channels (Wang et al , 1996; Stefani et al , 1996; Cheng et al , 1997). In this respect, topiramate is expected to provide a more selective therapy with fewer adverse effects, although the question of whether an absolute selectivity of a drug is desirable in seizure therapy that involves complex adaptive changes is still in doubt (Loscher, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…Short-term plasticity has been previously evaluated using paired pulse and fixed frequency train stimulation [3], [4], [5]. These methods do not test all the possible time intervals in a time efficient manner.…”
Section: Introductionmentioning
confidence: 99%