Effects of phloridzin on blood glucose and key enzyme G‐6‐Pase of gluconeogenesis in mice

Abstract

Diabetes mellitus (DM), a chronic endocrine metabolic disease, is characterized by hyperglycemia, lipid, and protein metabolism disorder. The prevalence rate of DM is high with various complications, which seriously affects the quality of life of patients, so it has been widely concerned by the society and the medical community (Ismail et al., 2017). Because of insulin resistance or impaired islet B cell function, blood glucose (BG) fluctuation often occurs during prediabetes and diabetes (Costantino et al., 2017), and long-term BG fluctuation has brought great harm.Therefore, it is of great significance to maintain the stability of BG. Liver gluconeogenesis is an important metabolic process to maintain BG homeostasis (Díaz-Lobo et al., 2015). Glucose-6-phosphatase (G-6-Pase), the key rate-limiting enzyme in the process of gluconeogenesis, is the last step to control glycogen decomposition and gluconeogenesis. G-6-Pase mainly catalyzes the hydrolysis of glucose 6-phosphate to glucose to maintain BG homeostasis. Taking liver gluconeogenesis as the target, it is of great significance to search safe and effective drugs or diet regulation methods to maintain the stability of BG, so as to control BG and reduce complications in diabetic patients (Zhang et al., 2019).

Bioactive Substances and Biological Functions in Malus hupehensis: A Review

“…Wang et al (2021) studied the effects of phlorizin (MH1) and the main component in MH leaves on blood glucose and glucose-6-phosphatase (G-6-Pase) to provide a scheme for blood glucose stability. The experimental results show that phlorizin (MH1) could promote the glucose uptake of insulin resistant HepG2 cells, improve the glucose tolerance of mice, and enhance the levels of FBG and PBG, and inhibit the expression levels of G-6-Pase protein, which had a positive effect on stabilizing the blood glucose of mice [ 49 ].…”

Supramolecular Architectures of 2-(3-(4-acetoxyphenyl)propanoyl)benzene-1,3,5-triyl triacetate (1) and 4-(3-(4-acetoxyphenyl)propanoyl)-5-hydroxy-1,3-phenylene diacetate (2)

“…Meanwhile, the benefits of phloridzin or other phloretin derivatives for human health are well documented by a number of publications and patents. Most of these relate to diabetes, obesity, stress hyperglycemia, membrane permeability and longevity-extending agents in foods, beverages, food additives, pharmaceuticals and cosmetics [5]- [10]. In order to be in compassion with the phloretin, two acetylation products of phloretin(2-(3-(4-acetoxyphenyl)propanoyl)benzene-1,3,5-triyl triacetate (1), C 25 H 22 O 9 and 4-(3-(4-acetoxyphenyl)propanoyl)-5-hydroxy-1,3-phenylene diacetate (2), C 21 H 20 O 8 , cf.…”