Effects of phosphinothricin on the isoenzymes of glutamine synthetase isolated from plant species which exhibit varying degrees of susceptibility to the herbicide

Ridley, Stuart M.; McNally, Sheila F.

doi:10.1016/0168-9452(85)90188-8

Cited by 53 publications

(27 citation statements)

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“…However, this is a relatively new herbicide and it is a contact herbicide with a very short selection pressure duration. There is considerable natural variation between species in sensitivity to glufosinate, and this variation does not appear to be based on differential sensitivity to GS (Ridley and McNally, 1985). Lines of oat that are insensitive to the GS-inhibiting glufosinate analog, tabtoxin, have a tabtoxin-resistant GS isozyme (Knight et al, 1988); however, no plants with glufosinate-resistant GS have been reported.…”

Section: Modes Of Action and Resistancementioning

confidence: 99%

Herbicide-Resistant Field Crops

Dekker

Duke

1995

Advances in Agronomy

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This chapter reviews information about how crop plants resist herbicides and how resistance is selected for in plants and surveys specific herbicide-resistant crops by chemical family. The discussion in the chapter includes HRCs derived from both traditional and biotechnological selection methodologies. Plants avoid the effects of herbicides they encounter by several different mechanisms. These mechanisms can be grouped into two categories: those that exclude the herbicide molecule from the site in the plant where they induce the toxic response and those that render the specific site of herbicide action resistant to the chemical. The chapter presents herbicide-resistant crops by the herbicide chemical family-such as, triazine, acetolactate synthatase, acetyl-CoA carboxylase, glyphosate, bromoxynil, phenoxycarboxylic acids, and glufosinate. Resistant crops are listed in the chapter regardless of whether they have been commercialized or were developed for experimental purposes only, and are provided regardless of their "success" as resistant plants. DisciplinesAgricultural Science | Agriculture | Agronomy and Crop Sciences | Weed Science CommentsThis article is

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Section: Modes Of Action and Resistancementioning

confidence: 99%

Herbicide-Resistant Field Crops

Dekker

Duke

1995

Advances in Agronomy

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“…Bialaphos is composed of a glutamic acid analog called phosphinothricin and two alanine residues. In plants and bacteria, bialaphos is metabolized by hydrolysis of the alanyl groups to produce phosphinothricin, which inhibits glutamine synthetase from bacteria and plants, thereby disrupting amino acid synthesis (65,(68)(69)(70)(71)(72). This metabolic site is not targeted by any herbicides developed by other strategies.…”

Section: Microbial Compounds With Herbicidal Potentialmentioning

confidence: 99%

Natural Phytotoxins as Herbicides

Duke

Lydon

1993

ACS Symposium Series

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“…As shown in previous research evaluating whole-plant tolerance (Nolte et al, 2004), reduced sensitivity to glufosinate is positively correlated to gdhA expression. Differential absorption and translocation of glufosinate from foliar applications in various plant species has been reported as the physiological basis for plant selectivity (Mersey et al, 1990;Ridley and McNally, 1985;Steckel et al, 1997;Maschhoff et al, 2000). Differential absorption and translocation of glufosinate from foliar applications in various plant species has been reported as the physiological basis for plant selectivity (Mersey et al, 1990;Ridley and McNally, 1985;Steckel et al, 1997;Maschhoff et al, 2000).…”

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confidence: 99%

“…One possible explanation for reduced sensitivity is through altered absorption or translocation of the herbicide by transformed plants. Differential absorption and translocation of glufosinate from foliar applications in various plant species has been reported as the physiological basis for plant selectivity (Mersey et al, 1990;Ridley and McNally, 1985;Steckel et al, 1997;Maschhoff et al, 2000).…”

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Glufosinate Absorption, Translocation, and Metabolic Fingerprint Effects in gdhA‐Transformed Tobacco

et al. 2017

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Tobacco (Nicotiana tabacum L.) expressing a modified Escherichia coli gdhA gene encoding NADPH‐dependent glutamate dehydrogenase (GDH) was resistant to the herbicide glufosinate. Differential plant sensitivity to glufosinate may result from changes in foliar absorption, translocation, plant metabolism, or metabolism around the blocked pathway(s). The objectives here were to determine if foliar absorption, translocation, or metabolism of glufosinate or metabolism around the blocked pathway(s) contribute to the resistance to glufosinate in gdhA‐transformed tobacco and to characterize changes in the metabolic profile in response to glufosinate as a result of transformation with gdhA. Foliar uptake and translocation of glufosinate was largely independent of the gdhA transgene or its expression. Thus, gdhA does not confer resistance to the transformed plants by altering the uptake or movement of glufosinate within tobacco plants. Using direct‐injection electrospray ionization and quadrupole time‐of‐flight mass spectrometry, the metabolic profiles of the two tobacco genotypes were different in response to glufosinate treatment, as determined by principal component analysis. The metabolic perturbation induced by glufosinate was lower in gdhA line 9 than gusA line 1, as evidenced by the reduced number of altered peaks recorded in leaves. Thus, gdhA‐transformed tobacco plants with low and high expression of GDH activity showed more stability of metabolism following the application of glufosinate than control plants. The predicted identity of ions suggested metabolic perturbations were lessened by gdhA in nitrogen assimilation, photorespiration, amino acid metabolism, nucleic acid metabolism, and cell signaling. Thus, use of the modified E. coli gdhA gene in transgenic plants can provide an additional mechanism for resistance to glufosinate.

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Effects of phosphinothricin on the isoenzymes of glutamine synthetase isolated from plant species which exhibit varying degrees of susceptibility to the herbicide

Cited by 53 publications

References 10 publications

Herbicide-Resistant Field Crops

Herbicide-Resistant Field Crops

Natural Phytotoxins as Herbicides

Glufosinate Absorption, Translocation, and Metabolic Fingerprint Effects in gdhA‐Transformed Tobacco

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