Effects of phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A expression in glomerular basement membranes on treatment response and renal outcome in membranous nephropathy

Yeter, Hasan Haci; Gönül, İpek Işık; Eraslan, Esra; Karacalik, Ceren; Öğüt, Betül; Güz, Galip

doi:10.1007/s10157-020-02011-6

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…We conducted a systematic review of the literature on previous studies involving double antigen-positive IMN. By June 6, 2023, a total of 11 studies (7,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) involving 43 dual antigen-positive IMN patients, were included (Supplementary Table 1, Supplementary Figure 2). Of the 43 patients, highly detailed information was available for only 11, and we extracted clinical, pathological, and prognostic information for these 11 patients (Table 2) and then performed comparisons with the 6 dual antigen-positive IMN patients at our center (Supplementary Table 2).…”

Section: Literature Review and Information Extraction Of Previous Rep...mentioning

confidence: 99%

Clinicopathological and prognostic characteristics of idiopathic membranous nephropathy with dual antigen positivity

Yang,

Wang,

et al. 2024

Front. Immunol.

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BackgroundIdiopathic membranous nephropathy (IMN) is the most common pathological type in adults with nephrotic syndrome. Many target antigens have been discovered. However, dual antigen-positive IMN patients are very rare, with only a few such cases being briefly described in various studies. There is no specific study on the clinicopathological and prognostic characteristics of dual antigen-positive IMN patients, and the disease characteristics of such patients remain unclear.MethodsImmunohistochemical staining of PLA2R, THSD7A, and NELL-1 was conducted on kidney tissue samples obtained from patients diagnosed with IMN. Simultaneously, the presence of corresponding serum antibodies was determined. Patients exhibiting positivity for dual antigens were included in the study, identified either through tissue staining or serum antibody detection. We retrospectively collected their clinical, pathological, and follow-up data and measured their serum antibody levels at multiple time points. Additionally, the same type of dual antigen-positive IMN cases reported in the literature were reviewed to extract clinical, pathological, and prognostic information. We compared the data for all of the above dual antigen-positive and PLA2R single-positive IMN cases at our center.ResultsWe identified 6 IMN patients with dual antigen positivity at our center, approximately 0.7% of whole MN series; the previous literature reports 43 IMN patients with dual antigen positivity, the proportion ranged from 0.2% to 2.8%. The IgG1 positivity rate in the renal tissue of the dual antigen-positive patients at our center was significantly lower than that of dual antigen-positive patients previously reported (16.7% vs. 100.0%, p=0.015), but there was no significant difference in clinical or prognostic aspects. Patients with dual antigen positivity reported at our center and in the literature were combined and compared with PLA2R single-positive IMN reported at our center. Compared with PLA2R single-positive IMN patients, dual antigen-positive IMN patients had a higher renal tissue IgG1 positivity rate (58.3% vs. 22.3%, p=0.016), and the time required to achieve remission was longer [13.5 (3.3,35.0) vs. 3.0 (1.0,8.0), p=0.052]. Overall, The changes in urine protein were consistent with the changes in serum PLA2R antibody levels in dual antigen-positive IMN patients.ConclusionsFor patients with primary membranous nephropathy who did not attain remission following prolonged treatment, multiple target antigen staining should still be actively performed, even with positivity for the PLA2R target antigen.

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Section: Literature Review and Information Extraction Of Previous Rep...mentioning

confidence: 99%

Clinicopathological and prognostic characteristics of idiopathic membranous nephropathy with dual antigen positivity

Yang,

Wang,

et al. 2024

Front. Immunol.

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“…In recent decades, some clinical [ 8 , 9 ], pathological [ 10 , 11 ], and genetic [ 12 , 13 ] parameters have been identified as biomarkers for predicting the prognosis of IMN, and the Kidney Disease Improving Global Outcomes (KDIGO) 2021 clinical practice guideline have taken 24 h urinary protein (UTP), estimate glomerular filtration rate(eGFR), serum anti-phospholipase A2 receptor antibody (sPLA2R-Ab), serum albumin (ALB) and others as indicators that may be used to divide patients into categories of low, moderate, high, and very high risk of progressive loss of kidney function [ 14 ]. However, there are often inconsistencies in various indicators in clinical practice, such as high level proteinuria in patients with low titer sPLA2R-Ab, or high level proteinuria with nomal serum ALB.…”

Section: Introductionmentioning

confidence: 99%

A dynamic online nomogram for predicting renal outcomes of idiopathic membranous nephropathy

Wang,

Xu,

Wang

et al. 2024

BMC Med Inform Decis Mak

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Background Because spontaneous remission is common in IMN, and there are adverse effects of immunosuppressive therapy, it is important to assess the risk of progressive loss of renal function before deciding whether and when to initiate immunosuppressive therapy. Therefore, this study aimed to establish a risk prediction model to predict patient prognosis and treatment response to help clinicians evaluate patient prognosis and decide on the best treatment regimen. Methods From September 2019 to December 2020, a total of 232 newly diagnosed IMN patients from three hospitals in Liaoning Province were enrolled. Logistic regression analysis selected the risk factors affecting the prognosis, and a dynamic online nomogram prognostic model was constructed based on extreme gradient boost, random forest, logistic regression machine learning algorithms. Receiver operating characteristic and calibration curves and decision curve analysis were utilized to assess the performance and clinical utility of the developed model. Results A total of 130 patients were in the training cohort and 102 patients in the validation cohort. Logistic regression analysis identified four risk factors: course ≥ 6 months, UTP, D-dimer and sPLA2R-Ab. The random forest algorithm showed the best performance with the highest AUROC (0.869). The nomogram had excellent discrimination ability, calibration ability and clinical practicability in both the training cohort and the validation cohort. Conclusions The dynamic online nomogram model can effectively assess the prognosis and treatment response of IMN patients. This will help clinicians assess the patient’s prognosis more accurately, communicate with the patient in advance, and jointly select the most appropriate treatment plan.

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THSD7A as a Promising Biomarker for Membranous Nephrosis

Jiang,

Lian

et al. 2023

Mol Biotechnol

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Effects of phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A expression in glomerular basement membranes on treatment response and renal outcome in membranous nephropathy

Cited by 5 publications

References 26 publications

Clinicopathological and prognostic characteristics of idiopathic membranous nephropathy with dual antigen positivity

Clinicopathological and prognostic characteristics of idiopathic membranous nephropathy with dual antigen positivity

A dynamic online nomogram for predicting renal outcomes of idiopathic membranous nephropathy

THSD7A as a Promising Biomarker for Membranous Nephrosis

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