Effects of photobiomodulation at various irradiances on normal and dihydrotestosterone‐treated human hair dermal papilla cells in vitro

Abstract

Androgenetic alopecia (AGA) is the most common type of hair loss caused by dihydrotestosterone (DHT) binding to androgen receptors in dermal papilla cells (DPCs). Photobiomodulation (PBM) is a promising treatment for AGA but suffers from inconsistent outcomes and inconsistent effective light parameters. This study investigated the impact of red light at various irradiances on normal and DHT‐treated DPCs. Our results suggested that red light at 8 mW/cm2 was most effective in promoting DPCs growth. Furthermore, a range of irradiances from 2 to 64 mW/cm2 modulated key signaling pathways, including Wnt, FGF, and TGF, in normal and DHT‐treated DPCs. Interestingly, 8 mW/cm2 had a greater impact on these pathways in DHT‐treated DPCs and altered the Shh pathway, suggesting that the effect of PBM varies with the cellular environment. This study highlights specific factors that influence PBM effectiveness and provides insight into the need for personalized PBM treatment approaches.

Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF2α

“…Photobiomodulation (PBM) is a non‐thermal and non‐invasive therapy that utilizes specific‐spectrum light (390–1100 nm) to modulate cellular activities and exert therapeutic effects [10–12]. In recent years, PBM therapy has been widely reported for Alzheimer's disease [13], skin rejuvenation and acne treatment [14], hair growth [15], spinal cord injury [16], and inflammation [17] and has received considerable attention in the field of biomedical research. LEDs have been widely applied in PBM due to their advantages such as high efficiency, long lifespan, flexible wavelength selection, and small size with low power consumption.…”