Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles <i>In Vitro</i>

Hakami, Abdulrahim R.; Alasmari, Sultan; Makkawi, Mohammed; Mansour, Adel Abo; Ahmad, Irfan; Shahrani, Mesfer Al; Alkhathami, Ali G.; Dera, Ayed A.; Tedla, Jaya Shanker; Almane, Saleh; Abudahish, Abdulaziz; AbuHadhyah, Jawaher; Alshehri, Majed; Mansour, Hanan Abo; Saad, Manar

doi:10.25289/ml.2020.9.2.172

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…According to Hakami et al, LLLT has an impact on the in vitro lipid and glycemic profiles of chosen healthy participants. Consequently, the application of LLLT may have therapeutic benefits for DM and dyslipidemia (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of Photo-Bio modulation on lipid profile in Patients with type 2 diabetes mellitus: A Randomized Clinical Trial

2023

JPTCP

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Objective: to investigate the low level laser therapy (LLLT) efficiency by using laser watch as an adjunctive therapy of dyslipidemia in type 2 diabetes mellitus (T2DM) patients. Methods:The study included sixty adult patients with diabetic dyslipidemia of both gender. They were split into two groups. Study group received anti diabetic drugs along with laser watch therapy (3 sessions /week for 12 weeks), while control group received only anti diabetic drugs. Blood sugar (FBS, 2HPP and HbA1C) and lipid panel (TG, TC, LDL and HDL) were measured before and at completion of the study.Results: A significant improvement in blood sugar and serum lipid profile was seen in both groups (P < 0.001), the study group, however, displayed more significant outcomes (P < 0.001). Conclusion:LLLT using laser watch can be used as a complementary treatment for dyslipidemia in T2DM patients to improve blood lipid profile and blood sugar.

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Section: Discussionmentioning

confidence: 99%

Effect of Photo-Bio modulation on lipid profile in Patients with type 2 diabetes mellitus: A Randomized Clinical Trial

2023

JPTCP

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“…From this perspective, periodontitis may be considered a risk factor for cardiovascular diseases such as atherosclerosis [ 38 ]. Regarding the influence of the laser on cholesterol levels, the literature provides conflicting results, with some studies suggesting an increase [ 41 ], while others report a decrease [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Infrared laser therapy decreases systemic oxidative stress and inflammation in hypercholesterolemic mice with periodontitis

Ribeiro,

de Souza Barroso,

Kampke

et al. 2023

Lipids Health Dis

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Background Near-infrared irradiation photobiomodulation (NIR-PBM) has been successfully used in periodontal treatment as an adjuvant tool to locally improve cell function and regeneration. Although the relationship between periodontitis and systemic disease constitutes an important aspect of periodontal clinical research, the systemic effects of NIR-PBM in periodontitis are not well known. In this study, we aimed to investigate the effects of NIR-PBM on systemic oxidative stress and inflammation in an apolipoprotein E (ApoE) knockout mouse model of periodontal disease (PD). Methods We evaluated alveolar bone loss by measuring the distance from the cementoenamel junction (CEJ) to the alveolar bone crest (ABC), reactive oxygen species (ROS) production in blood cells, inflammatory activity, plasma cholesterol levels, and lipid peroxidation levels in three experimental groups: (1) ApoEC, control group without intervention; (2) ApoEP, first molar ligation-induced periodontitis for 4 weeks; and (3) ApoEP + PBM, exposed to 808 nm continuous wave, ø ~ 3 mm2, 100 mW, 60 s of NIR-PBM for 7 consecutive days after 4 weeks of periodontitis. At the end of the experimental protocols, ApoEP mice presented significantly increased alveolar bone loss, ROS production, inflammatory activity, plasma cholesterol, and lipid peroxidation levels compared to the ApoEC group (P < 0.05). NIR-PBM for 7 days in the ApoEP + PBM mice significantly decreased systemic ROS production, inflammatory response, plasma cholesterol, and lipid peroxidation levels, similar to those found in the ApoEC group (P > 0.05). However, it was not capable of preventing alveolar bone loss (P > 0.05 compared to ApoEP mice). Conclusion A 7-day treatment with NIR-PBM effectively reduces systemic oxidative stress and inflammatory parameters in hypercholesterolemic mice with PD. However, more studies with longer evaluation times are needed to confirm the systemic effects of locally applied NIR-PBM on PD associated with hypercholesterolemia.

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Infrared laser therapy decreases systemic oxidative stress and inflammation in ApoE knockout mice with periodontitis

Ribeiro

Barroso

Kampke

et al. 2023

Preprint

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This study examines the effects of Photobiomodulation by near infrared irradiation (NIR-PBM) on oxidative and physiological stress in the apoliprotein E (ApoE-/-) knockout animal model with ligature-induced periodontal disease (PD). The animals were divided into three groups: ApoEC (without intervention); ApoEP (periodontitis); and ApoEP + L (periodontitis, NIR-PBM seven consecutive days). Alveolar bone loss (via scanning electron microscopy), quantification of reactive oxygen species (ROS) by flow cytometry, plasma cholesterol levels, inflammatory activity and plasma lipid peroxidation were evaluated. Alveolar bone loss was significant in the ApoEP group compared to the ApoEC group (p < 0.05). There was an increase in plasma cholesterol levels in the ApoEP group (p < 0.05) in relation to ApoEC; NIR-PBM reduced levels to levels below those of control animals. The ApoEP group had higher MPO levels when compared to the ApoEC group (p < 0.05). The superoxide anion and hydrogen peroxide increased in the ApoE P group in relation to the ApoEC (p < 0.05), ApoE P + L showed a reduction when compared to the ApoE P animals (p < 0.05) and the levels of hydrogen peroxide hydrogen were lower in the ApoEC group compared to ApoEP + L (p < 0.05). ApoEP group showed increased lipid peroxidation than ApoEC (p < 0.05), and animals that received NIR-PBM treatment had lower levels than ApoEP group (p < 0.05). In conclusion, NIR-PBM effectively reduces systemic parameters associated with PD progression in hypercholesterolemic animals. More studies with longer evaluation times are needed to elucidate the effects of PBM on experimental periodontitis related to hypercholesterolemia.

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Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles In Vitro

Cited by 3 publications

References 26 publications

Effect of Photo-Bio modulation on lipid profile in Patients with type 2 diabetes mellitus: A Randomized Clinical Trial

Effect of Photo-Bio modulation on lipid profile in Patients with type 2 diabetes mellitus: A Randomized Clinical Trial

Infrared laser therapy decreases systemic oxidative stress and inflammation in hypercholesterolemic mice with periodontitis

Infrared laser therapy decreases systemic oxidative stress and inflammation in ApoE knockout mice with periodontitis

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