Effects of photoperiod on circadian clock genes in skin contribute to the regulation of hair follicle cycling of Inner Mongolia white cashmere goats

Zhang, Chong Zhi; Sun, Hai Zhou; Zhang, Chun Hua; Jin, Lu; Shan, Dan; Li, Shengli

doi:10.1111/asj.13320

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…The growth of cashmere is affected by many factors, such as photoperiod, nutritional aspects, feeding management, and environmental climate; these can be manipulated by farmers to control the process of cashmere growth and thus promote its production from Cashmere goats (Mcgregor, 1998;McGregor, 2009;Liu et al, 2016;Zhang et al, 2016;Yang et al, 2017). Among these factors, the control of photoperiod is considered to be the easiest and most cost-effective way to enhance cashmere production (Zhang et al, 2019b). Short duration sunlight accelerates the growth of cashmere, while long duration sunshine decelerates it (Chong et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

Zhang

Wang

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Emerging studies show that melatonin promotes cashmere development through hypodermic implantation. However, the impact and underlying mechanisms are currently unknown. In vitro study has previously demonstrated that melatonin induces cashmere growth by regulating the proliferation of goat secondary hair follicle stem cells (gsHFSCs), but there is limited information concerning the effects of melatonin on cell pluripotency. It is also known that Wnt signaling may actively participate in regulating cell proliferation and stem cell pluripotency. Therefore, in the current investigation, goat hair follicle stem cells were exposed to multiple concentrations of melatonin and different culture times to reveal the relationship between melatonin and the activation of Wnt signaling. A proportionally high Catenin beta-1 (CTNNB1) response was induced by 500 ng/L of melatonin, but it was then suppressed with the dosages over 1,000 ng/L. Greater amounts of CTNNB1 entered the cell nuclei by extending the exposure time to 72 h, which activated transcription factor 4/lymphoid enhancer-binding factor 1 and promoted the expression of the proliferation-related genes C-MYC, C-JUN, and CYCLIND1. Moreover, nuclear receptor ROR-alpha (RORα) and bone morphogenetic protein 4 (BMP4) were employed to analyze the underlying mechanism. RORα presented a sluggish concentration/time-dependent rise, but BMP4 was increased dramatically by melatonin exposure, which revealed that melatonin might participate in regulating the pluripotency of hair follicle stem cells. Interestingly, NOGGIN, which is a BMP antagonist and highly relevant to cell stemness, was also stimulated by melatonin. These findings demonstrated that melatonin exposure and/or NOGGIN overexpression in hair follicle stem cells might promote the expression of pluripotency markers Homeobox protein NANOG, Organic cation/carnitine transporter 4, and Hematopoietic progenitor cell antigen CD34. Our findings here provided a comprehensive view of Wnt signaling in melatonin stimulated cells and melatonin mediated stemness of gsHFSCs by regulating NOGGIN, which demonstrates a regulatory mechanism of melatonin enhancement on the growth of cashmere.

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Section: Discussionmentioning

confidence: 99%

“…Cashmere is a type of amyelinic fiber produced from secondary hair follicles (SHFs) in Cashmere goats. The growth of cashmere is photoperiod-dependent, and shows seasonal changes in many goat breeds (Zhang et al, 2019b). Each year, cashmere starts growing in late-summer, halts growth in mid-winter, and naturally sheds in spring.…”

Section: Introductionmentioning

confidence: 99%

Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

Zhang

Wang

Zhang

et al. 2021

Front. Cell Dev. Biol.

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“…In this study, the β‐actin gene was used as an endogenous control, as the expression of β‐actin genes was shown to be stable in the maternal endometrium and fetal peri‐renal BAT of goats. Subsequently, ΔΔ Ct (Δ Ct sample − Δ Ct HS ) was determined, and the relative expression was calculated as 2 −ΔΔ Ct (Zhang et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Effects of dietary supplementation with N‐carbamylglutamate on maternal endometrium and fetal development during early pregnancy in Inner Mongolia white cashmere goats

Zhang

Shan

et al. 2022

Animal Science Journal

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This study investigated the effects of dietary supplementation with N‐carbamylglutamate (NCG) on maternal endometrium and fetal development during early pregnancy of Inner Mongolia white cashmere goats. Forty‐eight pregnant Inner Mongolia white cashmere goats (average age 3 years old, average lactation parity 2, and average body weight 43.81 ± 2.66 kg) were randomly allocated to three groups: a basal diet (control group, n = 16), a basal diet plus 0.30‐g NCG/d (NCG1 group, n = 16), and a basal diet plus 0.40‐g NCG/d (NCG2 group, n = 16). All of the does were housed in individual pens and the NCG treatment was conducted from Days 0 to 90 of pregnancy. At Days 17 and 90 of pregnancy, six representative pregnant does in each group were slaughtered. The current study results demonstrated that maternal NCG administration during early pregnancy effectively increased the arginine family of amino acids and the glucogenic amino acids concentrations and promoted the mRNA expression of osteopontin (OPN), αv and β3 integrins, and endometrial development of Inner Mongolia white cashmere goats. The supplementation improved the fetal brown adipose tissue (BAT) stores and the mRNA expression of UCP‐1 and BMP7, thereby helping to the fetal early development.

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Molecular insights into Pashmina fiber production: comparative skin transcriptomic analysis of Changthangi goats and sheep

Ahlawat,

Vasu,

Mir

et al. 2024

Mamm Genome

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Effects of photoperiod on circadian clock genes in skin contribute to the regulation of hair follicle cycling of Inner Mongolia white cashmere goats

Abstract: The production and quality of cashmere are affected by nutritional, environmental and genetic conditions of the goats, and the seasonal photoperiod can induce the animals to increase cashmere production without obvious deleterious effects on the cashmere fibers (Liu et al.,

Cited by 5 publications

References 38 publications

Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

Effects of dietary supplementation with N‐carbamylglutamate on maternal endometrium and fetal development during early pregnancy in Inner Mongolia white cashmere goats

Molecular insights into Pashmina fiber production: comparative skin transcriptomic analysis of Changthangi goats and sheep

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