Effects of physical activity and diet on lipoprotein(a)

Mackinnon, Laurel Traeger; Hubinger, Lyle; Lepre, F.

doi:10.1097/00005768-199711000-00007

Cited by 48 publications

(34 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At present, knowledge from cross-sectional as well as intervention studies does not suggest that plasma Lp(a) concentrations are significantly altered by physical activities or diet modifications recommended for health improvements [41][42][43]. This is in good agreement with our finding of only a negligible variation between pre-and postintervention Lp(a) values in the total group; neither caloric restriction and weight changes nor the nutrient quality showed any influence on the Lp(a) concentrations in the patients investigated.…”

Section: Discussionmentioning

confidence: 89%

“…Regarding the effects of exercise, weight loss, and diet modifications on cholesterol and lipoproteins, a small remark has to be made on the effect of lifestyle management of Lp(a) [41]. At present, knowledge from cross-sectional as well as intervention studies does not suggest that plasma Lp(a) concentrations are significantly altered by physical activities or diet modifications recommended for health improvements [41][42][43].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of an Oat Bran Enriched Diet on the Atherogenic Lipid Profile in Patients with an Increased Coronary Heart Disease Risk

et al. 2003

View full text Add to dashboard Cite

Aim: To study whether an oat bran enriched diet has a specific effect in lowering total and low-density lipoprotein cholesterols, in addition to caloric and fat restriction. Methods: We performed a randomized, controlled, parallel-group, single-centre study in which 1,994 patients from the Wehrawald Hospital (Todtmoos, Germany) were screened and 235 met the criteria male gender, hypercholesterolemia, and overweight. All patients in the Wehrawald Hospital took part in a 4-week standardized inpatient lifestyle health program consisting of dietary intervention, increased physical activity, and health education. Caloric restriction, fat modification, and oat bran supplementation were part of the nutritional regimen within the lifestyle health program. Ninety-nine patients were randomized to a fat-modified diet with caloric restriction and a daily intake of 35–50 g oat bran and 136 patients to a fat-modified, oat bran-free diet with caloric restriction. Fifty-three male overweight but normocholesterolemic subjects were selected as controls. Results: The most significant decreases in total cholesterol (–67.7 ± 37.2 mg/dl; p < 0.01), low-density lipoprotein cholesterol (–56.3 ± 35.1 mg/dl; p < 0.01), and apolipoprotein B (–42.4 ± 34.1 mg/dl; p < 0.01) were found with the combination of the fat-modified and oat bran enriched food. Conclusions: Added to a fat-modified diet, oat bran within a practical range of intake significantly reduces total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B. These beneficial effects occurred independent of covariables such as physical activity or caloric and fat restriction in the diet.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Effect of an Oat Bran Enriched Diet on the Atherogenic Lipid Profile in Patients with an Increased Coronary Heart Disease Risk

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Several population and cross-sectional studies showed a lack of association between serum Lp(a) levels and regular moderate physical activity or moderate exercise training. [20][21][22][23][24]29 The few studies that found a beneficial effect of exercise on Lp(a) were either confounded by ethnical issues 25 or included only men. 26 Therefore, it appears likely that the changes in Lp(a) levels observed in our study were caused by the dietary intervention rather than by the increased physical activity.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Similarly, the effect of physical exercise on Lp(a) levels is not fully understood, with several contradicting reports. [20][21][22][23][24][25][26][27][28][29] Only few studies were performed in children. 27,28 In this study, we therefore tested the possibility of lowering Lp(a) levels by a weight reduction program during a 3-week dietary camp for obese children.…”

Section: Introductionmentioning

confidence: 99%

Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

et al. 2009

View full text Add to dashboard Cite

Background: Lipoprotein(a) [Lp(a)] is considered an independent risk factor for cardiovascular disease. Its concentration is mainly determined by the kringle-IV repeat copy number variation (CNV) at the apolipoprotein(a) [apo(a)] locus. Objective: We aimed to investigate the immediate effect of weight reduction on plasma Lp(a) levels and its dependency on the apo(a) CNV in obese children. Design: We performed a prospective longitudinal intervention study of a low-fat hypocaloric diet conducted in a 3-week dietary camp for obese children. In all, 140 obese participants (54 boys and 86 girls) with a mean age of 12.5 ± 1.6 years and a mean relative body mass index (BMI) before treatment of 165.6±24.7% were included. Body weight and plasma levels of Lp(a), lipids, apolipoproteins A-I and B, insulin, and C-reactive protein were determined before the onset and after the end of the intervention. In addition, the number of apo(a) kringle-IV repeats were determined using sodium dodecyl sulfate agarose gel electrophoresis. Results: The mean loss of body weight was 5.0 ± 1.3 kg (À6.6%), resulting in a mean decrease of the relative BMI of 6.6%. Blood chemistry revealed significant changes in all parameters, especially in Lp(a), with a decrease from 24.4 ± 30.6 to 17.9 ± 22.6 mg per 100 ml or À19% (Po0.001). The decrease of Lp(a) levels was higher in the group with low compared with high molecular weight apo(a) phenotypes (À23.9 vs À16.6%). Conclusions: Weight reduction in obese children is associated with significant changes in Lp(a) levels, especially in subjects with high pre-treatment Lp(a) concentrations. This effect is markedly influenced by the molecular phenotype at the copy-number variable apo(a) locus.

show abstract

“…two-fold relative risk of coronary atherosclerosis [3] rising to the range of five-fold when LDL and Lp(a) are both elevated [4] reduction of plasma Lp(a) concentration is recommended. Dietary interventions do not seem to be effective in lowering Lp(a) plasma levels [9,83] or even lead to an increase of Lp(a) in plasma, alone [84] or at least when combined with exercise 85]. The same phenomenon could be observed in case of exercise where cross-sectional data suggest that a lifestyle of moderate to intense exercise training does not exert a significant impact on the Lp(a) level [86,87].…”

Section: Lp(a) and Lipid Lowering Drugsmentioning

confidence: 99%

Lipoprotein (a) – An Overview

Gries¹

2012

Lipoproteins - Role in Health and Diseases

View full text Add to dashboard Cite

Effects of physical activity and diet on lipoprotein(a)

Cited by 48 publications

References 55 publications

Effect of an Oat Bran Enriched Diet on the Atherogenic Lipid Profile in Patients with an Increased Coronary Heart Disease Risk

Effect of an Oat Bran Enriched Diet on the Atherogenic Lipid Profile in Patients with an Increased Coronary Heart Disease Risk

Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

Lipoprotein (a) – An Overview

Contact Info

Product

Resources

About