BackgroundHealth‐related quality of life (HRQOL) is unequal between countries and regions, and the emphasis on HRQOL of populations of low‐income countries and regions is unprecedented.ObjectivesTo examine the association between family health and HRQOL among middle‐aged and older adults in rural China, and determine whether this association differs by age, gender and chronic disease subgroup.MethodsCross‐sectional survey carried out from July to September 2021. The participants were 1059 people aged 46 and over living in rural China. We used the European Quality of Life Five Dimension Five Level (EQ‐5D‐5L) and Family Health Scale‐Short Form (FHS‐SF) to assess health‐related quality of life (HRQOL) and family health, respectively.ResultsThe mean EQ‐VAS was 75.66, the mean EQ index score was 0.92, and the mean FHS was 37.90 in rural middle‐aged and older adults. After Bonferroni correction, generalised linear regression models showed that FHS was significantly associated with the EQ‐VAS (β = 0.829; 95% confidence interval [CI]: 0.660 to 0.997; p < .001) and the EQ index score (β = 0.003; 95%CI: 0.001 to 0.004; p < .001). Binary logistic regression models showed that FHS was associated with three dimensions of HRQOL (mobility, self‐care and usual activities) (p < .01). Based on subgroup analyses, the effect of FHS on EQ‐VAS and the EQ index score was significant in three subgroups after Bonferroni correction (p < .01), but the association between FHS and the dimensions of HRQOL differed by age, gender and chronic disease group (p > .01).ConclusionsThis study is the first to explore that family health and its dimensions are significant positive predictors of HRQOL among middle‐aged and older adults in rural China. Family‐based measures may have more potential and value because better family health significantly improves HRQOL.Implications for practiceIn the health strategy, the government and primary health care workers should include family health as an indicator and assess it before and after the implementation of the strategy.