Effects of physical exercise during adjuvant breast cancer treatment on physical and psychosocial dimensions of cancer-related fatigue: A meta-analysis

Vulpen, Jonna K. van; Peeters, Petra H.; Velthuis, Miranda J.; Wall, Elsken van der; May, Anne M.

doi:10.1016/j.maturitas.2015.12.007

Cited by 191 publications

(177 citation statements)

References 30 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…Consistent with our hypothesis, we observed a direct effect of change in physical activity on FRDI, such that increased engagement in physical activity across the pre- to post-intervention period predicted less interference in daily life as a result of fatigue. This finding is largely congruent with conclusions from meta-analyses that physical activity during treatment mitigates fatigue [39, 40]. While most research focuses on fatigue intensity [41–43], the present study is novel in its investigation of the unique role FRDI may play in the effects of physical activity on psychosocial functioning during breast cancer treatment.…”

Section: Discussionsupporting

confidence: 88%

How changes in physical activity relate to fatigue interference, mood, and quality of life during treatment for non-metastatic breast cancer

Fisher

Jacobs

Taub

et al. 2017

General Hospital Psychiatry

View full text Add to dashboard Cite

Objective Physical activity (PA) following surgery for breast cancer may improve depressive symptoms and quality of life (QoL) via reduction in fatigue-related daily interference (FRDI). Less is known about how change in PA may relate to these psychosocial factors throughout the course of treatment. In a secondary analysis of a previous psychosocial intervention trial, we examined relationships between change in PA, depressive symptoms, and functional QoL, as mediated by change in FRDI, and whether naturally occurring change in PA provided benefit independent of the intervention. Method Women (N=240) with non-metastatic stage 0-III breast cancer were randomized to Cognitive-Behavioral Stress Management (CBSM) or a control 2–10 weeks post-surgery. PA, FRDI, clinician-rated depressive symptoms, self-reported depressed mood, and functional QoL were assessed at baseline and three months post-intervention. Results Increased PA was associated with reductions in clinician-rated depressive symptoms, depressed mood, and improved QoL, mediated by a reduction in FRDI. This was above and beyond the effect of CBSM. Conclusions Increased PA may mitigate FRDI and improve depressive symptoms and functional QoL for women undergoing breast cancer treatment, beyond effects of a psychosocial intervention. Benefits of an integrated PA and psychosocial approach should be investigated further.

show abstract

Section: Discussionsupporting

confidence: 88%

How changes in physical activity relate to fatigue interference, mood, and quality of life during treatment for non-metastatic breast cancer

Fisher

Jacobs

Taub

et al. 2017

General Hospital Psychiatry

View full text Add to dashboard Cite

show abstract

“…Physical activity has also been shown to reduce the impact of adverse effects experienced in the adjuvant breast cancer setting, including fatigue, 40 arthralgia, 41 and menopausal symptoms. 42 Medication-taking behavior was not assessed as an outcome within these trials, and the extent to which improving symptoms and adverse effects by physical activity translates to improved adherence remains an unexplored hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Participant-Reported Symptoms and Their Effect on Long-Term Adherence in the International Breast Cancer Intervention Study I (IBIS I)

Smith

Šestak

Howell

et al. 2017

JCO

View full text Add to dashboard Cite

PurposeTo assess the role of participant-reported symptoms on long-term adherence to preventive therapy in the United Kingdom sample of the International Breast Cancer Intervention Study (IBIS-I). IBIS-I was a randomized controlled trial that investigated the effectiveness of tamoxifen in reducing the risk of breast cancer among women at increased risk of the disease.Participants and MethodsWomen were randomly assigned to tamoxifen versus placebo (20 mg/day; n = 4,279). After 456 exclusions, 3,823 women were included in this analysis. Adherence (< 4.5 years or ≥ 4.5 years) was calculated using data from six monthly clinical visits. Analyses were adjusted for age, Tyrer-Cuzick risk, smoking, use of hormone replacement therapy, menopausal status, baseline menopausal symptoms, and treatment.ResultsOverall, 69.7% of women were adherent for at least 4.5 years (tamoxifen: 65.2% v placebo: 74.0%; P < .001). Differences in adherence between treatment arms were observed from 12 months onward (all P < .01) and were largest at 54 months. Dropout rates were highest in the first 12 to 18 months and decreased thereafter. Women reporting nausea/vomiting were less likely to be adherent in both the tamoxifen (odds ratio [OR], 0.57; 95% CI, 0.37 to 0.86; P = .007) and placebo (OR, 0.58; 95% CI, 0.37 to 0.93; P = .023) arms. Headaches were associated with adherence only in the placebo arm (OR, 0.62; 95% CI, 0.42 to 0.91; P = .016), whereas gynecologic symptoms were significant only in the tamoxifen arm (OR, 0.77; 95% CI, 0.62 to 0.97; P = .024). Effect sizes for each symptom on adherence were not significantly different between the treatment groups (P > .05). In both treatment arms, we observed significant trends for lower adherence with increasing severity for all symptoms (P < .01) except headaches (P = .054).ConclusionIn the IBIS-I trial, experiencing predefined symptoms in the first 6 months reduced long-term adherence. Effects were similar between treatment arms, suggesting that women were attributing age-related symptoms to preventive therapy. Interventions were required to support symptom management.

show abstract

“…fatigue) or emotional barriers (e.g. depression) can render decision making for PA more difficult for cancer survivors by limiting the activity of women after diagnosis and, then, enhance effectively weight gain, fatigue, deterioration of lean muscle mass and, overall reduction in physical functioning (van Vulpen, Peeters, Velthuis, van der Wall, & May, 2016;Brawley et al, 2003). Moreover, in precontemplation stage, Skinner, Champion, and Hanna (1997) observed that information concerning benefits of PA did not convince precontemplators to form an intention.…”

Section: Discussionmentioning

confidence: 99%

Barriers Identification as Intervention to Engage Breast Cancer Survivors in Physical Activity

André

Pillaud

Davoust

et al. 2018

Psychosocial Intervention

View full text Add to dashboard Cite

Although scientific evidence supports the role of physical activity (PA) as a safe and effective intervention for improving health-related quality of life (for a review, see Mishra et al., 2012;Irwin, 2009), the majority of cancer survivors do not comply with public health guidelines (Blanchard, Courneya, & Stein, 2008;Lynch et al., 2010), i.e. at least 150 minutes per week of moderate-intensity aerobic PA throughout the week or at least 75 minutes of vigorous-intensity aerobic PA throughout the week, or an equivalent combination of This study was designed to demonstrate the advantage of adding cancer barriers to components of decision-making in the transtheoretical model (TTM). In study 1, questionnaires were completed by 139 breast cancer survivors including decisional balance, cancer-related barriers and stages of readiness. In study 2, efficiency of directly tackling cancer-related barriers through motivational-style conversation was tested in a quasi-experimental design. From study 1, all decisionmaking variables were related to stages of readiness, but cancer-related barriers were the sole predictors of engagement in physical activity. Out of the three groups of study 2, only the group with motivational-style conversation displayed a significant progress for engagement in physical activity. Demonstrating that cancer-related barriers predict stage of change above the effects of the two components of decisional balance provides a validation of positions that put cancer-related barriers as uniquely related to stages of change, and suggests that adding them in decision making variables in TTM's model can provide a genuinely new contribution to the understanding of physical activity adherence. Regarding implication for cancer survivors, these results suggest that in order to stimulate progress in early stages of change, a greater emphasis may be needed on reducing cancer-related barriers. La identificación de barreras como intervención para involucrar a supervivientes de cáncer de mama en actividades físicas R E S U M E NEste estudio fue diseñado para demostrar la ventajas de tener en cuenta las barreras relacionadas con el cáncer en el proceso de toma de decisiones en el modelo transteórico. En el estudio 1 los cuestionarios fueron respondidos por 139 supervivientes de cáncer de mama, en ellos se incluyó el equilibrio decisional, las barreras relacionadas con el cáncer y las etapas de preparación. En el estudio 2 la eficacia de abordar las barreras relacionadas con el cáncer a través de conversaciones de tipo motivacional se puso a prueba con un diseño cuasi-experimental. En el estudio 1 todas las variables de toma de decisiones se relacionaron con las etapas de preparación, pero las barreras relacionadas con el cáncer fueron los únicos predictores de la participación en la actividad física. De los tres grupos del estudio 2, sólo el grupo con conversación de tipo motivacional mostró un progreso significativo para la participación en la actividad física. Demostrar que las barreras relacionadas con el cáncer pre...

show abstract

Effects of physical exercise during adjuvant breast cancer treatment on physical and psychosocial dimensions of cancer-related fatigue: A meta-analysis

Cited by 191 publications

References 30 publications

How changes in physical activity relate to fatigue interference, mood, and quality of life during treatment for non-metastatic breast cancer

How changes in physical activity relate to fatigue interference, mood, and quality of life during treatment for non-metastatic breast cancer

Participant-Reported Symptoms and Their Effect on Long-Term Adherence in the International Breast Cancer Intervention Study I (IBIS I)

Barriers Identification as Intervention to Engage Breast Cancer Survivors in Physical Activity

Contact Info

Product

Resources

About