Effects of physical exercise in people with epilepsy: A systematic review and meta-analysis

Duñabeitia, Iratxe; Bidaurrazaga‐Letona, Iraia; Diz, José Carlos; Colon-Leira, Sergio; García-Fresneda, Adrián; Ayán, Carlos

doi:10.1016/j.yebeh.2022.108959

Cited by 25 publications

(11 citation statements)

References 36 publications

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“…The reduction in the proportion of stillbirths observed in the experimental group engaged in aerobic exercise, although not statistically signi cant, may be attributed to the decrease in seizure duration leading to a reduction in in ammation and hypoxia stemming from seizures. Notably, moderate-intensity aerobic exercise was found to shorten the overall seizure duration compared to sedentary rats treated with PTZ, aligning with previous ndings on the impact of aerobic exercise in reducing seizures [14,15,17]. Some studies have highlighted the potential of physical exercise in regulating neuronal excitability [30], with exercise being able to enhance the brain GABA neuropeptide activity that inhibits hippocampal excitability [17].…”

Section: Discussionsupporting

confidence: 83%

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Sabaghi,

Yousofvand

2024

Preprint

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Objective Seizures during pregnancy have been linked to adverse outcomes for newborns and motor coordination (MC) defects in offspring. Physical activity has shown promise in reducing seizure severity and promoting positive outcomes for newborns. In this study, we investigated the impact of aerobic exercise during pregnancy on seizure activity in pregnant mice treated with pentylenetetrazole (PTZ) and the MC of preadolescence male mice.Methods Adult female ICR mice were divided into two groups and administered PTZ or saline for 30 days before mating. PTZ treatment continued throughout pregnancy for the experimental group, while the control group received saline. Active pregnant mice engaged in aerobic treadmill exercises from the first to the 20th day of pregnancy. MC in preadolescence male offspring was assessed using the rotarod test.Results Prenatal exposure to maternal seizures induced by PTZ resulted in MC deficiencies in preadolescence male offspring (P < 0.05). Aerobic exercise during pregnancy demonstrated beneficial effects on convulsive activity (P < 0.05) and was able to counteract the MC deficits caused by maternal seizures during pregnancy.Conclusion These findings suggest aerobic exercise during pregnancy may serve as a supplementary therapeutic approach to reduce convulsive activity and mitigate MC impairments in preadolescence male offspring.

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Section: Discussionsupporting

confidence: 83%

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Sabaghi,

Yousofvand

2024

Preprint

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“…Additionally, previous research and reviews have reported additional gaps in research related to better understanding the relationship between other lifestyle factors (eg, side effects from anti-epileptic medication) and PA for PWE. 49,50 Overall, future PA-based interventions for PWE should focus on how sustained PA levels change can impact cognitive functioning and health outcomes (eg, seizure frequency, adverse symptoms).…”

Section: Discussionmentioning

confidence: 99%

Lifestyle Behavioral Interventions and Health-Related Outcomes Among People with Epilepsy: A Review of Randomized Controlled Trials

Sauls,

Buro,

Kirby

2024

Am J Health Promot

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Objective To gather and assess current literature on the prevalence and efficacy of lifestyle behavioral interventions (sleep, nutrition, physical activity) for health outcomes, including QOL, psychological well-being, behavioral changes, and seizure frequency, among PWE. Data Source A review was conducted of English-language articles identified from PubMed, Scopus, and Embase between January 2013 to January 2023. Study Inclusion and Exclusion Criteria Inclusion criteria were randomized controlled trials (RCT) with human subjects diagnosed with epilepsy who participated in a lifestyle behavioral intervention. Data Extraction Two researchers independently completed the title, abstract, and full-text reviews. Information extracted includes study population, duration, type of intervention, findings, and outcomes. Data Synthesis Data was narratively synthesized to show level of evidence and degree of consistency in findings. Results: 4001 studies identified, 66 full texts reviewed, and 24 included. A majority (n = 16) of studies utilized diet specific RCTs, and some focused on physical activity (n = 7) and sleep (n = 1). Diet-specific RCTs (eg, ketogenic, Modified Atkins) reported reduced seizure frequency with adverse effects, such as gastrointestinal complications. Physical activity-based interventions found that maintained levels of exercise improved QOL and psychological well-being. However, physical activity and diet-based interventions did not have lasting effects after study conclusion. Only the behavioral sleep intervention reported that sleep quality improved significantly and was maintained post-intervention. Conclusion Future research is needed to establish the relationship between lifestyle behavioral interventions on QOL and other health outcomes (eg, seizure frequency).

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“…Hypothyroidism and its associated impairments have generally received less attention from researchers and clinicians with regard to the effect of exercise training compared to other chronic health disorders. Nevertheless, some studies have investigated the potential therapeutic advantages of exercise training individuals suffering with clinical hypothyroidism [16][17][18]. Two of these studies found exercise to increase FT4 and FT3 level and reduce TSH in hypothyroid patients [16,17]; it was possible that the physical activity modulated circulating TSH levels by exerting a regulatory role on the hypothalamic-pituitary axis [19].…”

Section: Original Articlementioning

confidence: 99%

“…Two of these studies found exercise to increase FT4 and FT3 level and reduce TSH in hypothyroid patients [16,17]; it was possible that the physical activity modulated circulating TSH levels by exerting a regulatory role on the hypothalamic-pituitary axis [19]. However, a recent review found that physical activity in hypothyroid patients does not affect thyroid function, despite enhancing mental and physical health [18].…”

Section: Original Articlementioning

confidence: 99%

Comparative effects of aerobic, resistance, and combined exercises on depression and sleep quality in women with controlled hypothyroidism. A randomized controlled trial

Elgayar,

Elgendy,

Youssef

2024

areh

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Introduction: Interest has recently frown in the use of exercise in managing hypothyroidism associated impairments. The objective of this research was to assess and contrast the effects of aerobic and resistance exercise regimens, and a combination of both, on depressive symptoms and sleep quality in women with managed hypothyroidism. Material and methods: A total of sixty women, aged 35 to 45 years, with controlled hypothyroidism associated with depression, and sleep problems were randomly assigned to four equally-sized groups: aerobic exercise (AE), resistance exercise (RE), combined AE/RE, and a control group. They engaged in low to moderate intensity workouts, three times a week, during a span of 12 weeks, while also undergoing levothyroxine therapy. Outcome measures included depression assessed with the Beck Depression Inventory II (BDI-II) and sleep quality, evaluated using the Pittsburgh Sleep Quality Index (PSQI). Results: The BDI-II and PSQI showed significant improvements in all exercise groups in comparison to the first measurements and the non-exercising group (p < 0.05). Most significantly, the AE/RE group demonstrated greater improvements in both outcomes then the AE and RE groups alone (p < 0.05). Conclusions: In well-managed hypothyroid women, AE, RE, and combined AE/RE can improve depression and sleep quality. However, combined AE/RE appears to induce the greatest improvements in both measures.

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Effects of physical exercise in people with epilepsy: A systematic review and meta-analysis

Cited by 25 publications

References 36 publications

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Lifestyle Behavioral Interventions and Health-Related Outcomes Among People with Epilepsy: A Review of Randomized Controlled Trials

Comparative effects of aerobic, resistance, and combined exercises on depression and sleep quality in women with controlled hypothyroidism. A randomized controlled trial

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