Effects of physical training on serum and pituitary growth hormone contents in diabetic rats

Leme, José Alexandre Curiacos de Almeida; Araújo, Michel Barbosa de; Moura, Leandro Pereira de; Gomes, Ricardo José; Moura, Rodrigo Ferreira de; Rogatto, Gustavo Puggina; Mello, María Alice Rostom de; Luciano, Eliete

doi:10.1007/s11102-009-0178-y

Cited by 4 publications

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“…The lower body and ventricular weights of diabetic animals indicate that they had impaired growth. In rats with diabetes induced by STZ, in addition to insulin, the secretion of hormones such as the growth hormone, glucagon, pancreatic polypeptide and, consequently, growth factor similar to that of insulin, are altered and affect the growth [34][35][36] . It is also known thatdiabetes induces increased use of fatty acids and accelerates protein catabolism 37 .…”

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confidence: 99%

Treinamento em natação atenua a disfução contrátil de cardiomiócitos de ratos diabéticos

Silva

Pelúzio

Amorim

et al. 2011

Arq. Bras. Cardiol.

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Section: +mentioning

confidence: 99%

Treinamento em natação atenua a disfução contrátil de cardiomiócitos de ratos diabéticos

Silva

Pelúzio

Amorim

et al. 2011

Arq. Bras. Cardiol.

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“…Thus far, in studies using T2DM animals prepared by the administration of alloxan, the blood lipid profile could not be improved by forced swimming at 3.5% load of body weight (BW) [ 11 ], however, it could be improved by forced swimming at 90% of the maximal lactate steady state [ 12 ]. Ribeiro [ 13 ] stated that physical training at high intensity is important for obtaining better blood lipid profile changes.…”

Section: Introductionmentioning

confidence: 99%

Blood lipid profile changes in type 2 diabetic rats after tail suspension and reloading

et al. 2021

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Purpose The effects of the tail suspension and reloading on the protein and lipid metabolism in muscle and blood in type 2 diabetes mellitus (T2DM) are unclear. This study evaluated the hypothesis that skeletal muscle catabolism is greater in T2DM than in non-diabetes mellitus (non-DM) rats and that the activity-dependent changes in the intramuscular lipid accumulation and blood lipid profile are poorer in T2DM than in non-DM rats. Methods T2DM and non-DM rats were suspended for two weeks followed by reloading for two weeks. The muscle and blood were then examined. Results In contrast to our hypothesis, there was no marked difference between the T2DM and non-DM groups in terms of the skeletal muscle catabolism and activity-dependent changes in intramuscular lipid accumulation. However, the blood lipid profile increased in the T2DM group compared to the non-DM group. One interesting finding in this study was the decrease in non-high-density lipoprotein (non-HDL) cholesterol levels after one week of reloading followed by a significant increase in the non-HDL cholesterol levels after two weeks of reloading in the T2DM group. Conclusion These results suggest that a dramatic increase in activity after a period of inactivity may rapidly improve the blood lipid profile in T2DM rats.

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“…After 7 days of moderate intensity training on a treadmill, the same result was found. Alloxan-induced diabetes resulted in hypertriglyceridemia in adult animals [19]. Continuous swim exercise at moderate intensity reduced triglyceride levels [19].…”

Section: Introductionmentioning

confidence: 99%

“…Alloxan-induced diabetes resulted in hypertriglyceridemia in adult animals [19]. Continuous swim exercise at moderate intensity reduced triglyceride levels [19]. The authors have suggested that this change in the triglyceridemia of animals induced by physical training is due to a modulation of lipoprotein lipase activity [20,21].…”

Section: Introductionmentioning

confidence: 99%

Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan

et al. 2012

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BackgroundType 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by insulin resistance. Its development is directly connected with the inability of insulin to exert its action, not just on carbohydrate metabolism but also on primarily on lipid metabolism. The present study aimed to compare the effects of continuous, intermittent, and strength training on serum and tissue variables on the lipid metabolism of alloxan rats.MethodsWistar rats were divided into eight groups: sedentary alloxan (SA), sedentary control (SC), continuous training alloxan (CA), intermittent training alloxan (IA), strength training alloxan (StA), continuous training control (CC), intermittent training control (IC) and strength training control (StC). Alloxan (250 mg/kg bw) was injected into neonatal rats at 6 days of age. The continuous training protocol consisted of 12 weeks of swimming training for 1 uninterrupted hour / day, five days/ week, supporting a load that was 5% bw. The intermittent training protocol consisted of 12 weeks of swimming training with 30 s of activity interrupted by 30 s of rest, for a total of 20 min/day, five days/ week, supporting a load that was 15% bw. The strength-training protocol consisted of 12 weeks of training, five days/week with 4 sets of 10 jumps in water with 1 min rest between sets, supporting a load that was a 50% bw.ResultsAt 28 days, the alloxan animals exhibited higher insulin resistance as measured by the disappearance of glucose serum (% Kitt/min) during the ITT. At 120 days, the sedentary alloxan animals showed higher FFA values than continuous and intermittent training alloxan. In addition, the alloxan animals that underwent intermittent and strength training showed lower FFA values compared to the corresponding controls. The continuous training protocol was less effective than the strength training protocol for reducing the levels of total cholesterol in the alloxan animals. Serum total lipid values revealed that intermittent training increased serum levels in alloxan animalsConclusionThus, it was concluded that physical training at different intensities of effort is of great importance in attenuation and control of changes in the lipid metabolism in alloxan animals.

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Effects of physical training on serum and pituitary growth hormone contents in diabetic rats

Cited by 4 publications

References 28 publications

Treinamento em natação atenua a disfução contrátil de cardiomiócitos de ratos diabéticos

Treinamento em natação atenua a disfução contrátil de cardiomiócitos de ratos diabéticos

Blood lipid profile changes in type 2 diabetic rats after tail suspension and reloading

Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan

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