Effects of phytase and coccidial vaccine on growth performance, nutrient digestibility, bone mineralization, and intestinal gene expression of broilers

Shi, Hanyi; Wang, Jinquan; Teng, Po-Yun; Tompkins, Yuguo Hou; Jordan, Brian J.; Kim, Woo Kyun

doi:10.1016/j.psj.2022.102124

Cited by 17 publications

(23 citation statements)

References 89 publications

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“…The right tibia bones were collected on Days 8 and 19 from one bird per replicate (6 bones/treatment) and stored at −20 °C until bone ash analysis. Bone ash analysis was performed using the parameters reported by [ 62 , 63 ]. Briefly, the initial wet weight of each bone was recorded, followed by drying at 100 °C for 24 h, and dry bone weight was recorded.…”

Section: Methodsmentioning

confidence: 99%

Aflatoxin B1 Impairs Bone Mineralization in Broiler Chickens

Paneru,

Sharma,

Shi

et al. 2024

Toxins

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Aflatoxin B1 (AFB1), a ubiquitous mycotoxin in corn-based animal feed, particularly in tropical regions, impairs liver function, induces oxidative stress and disrupts cellular pathways, potentially worsening bone health in modern broilers. A 19-day experiment was conducted to investigate the effects of feeding increasing levels of AFB1-contaminated feed (<2, 75–80, 150, 230–260 and 520–560 ppb) on bone mineralization markers in broilers (n = 360). While growth performance remained unaffected up to Day 19, significant reductions in tibial bone ash content were observed at levels exceeding 260 ppb. Micro-computed tomography results showed that AFB1 levels at 560 ppb significantly decreased trabecular bone mineral content and density, with a tendency for reduced connectivity density in femur metaphysis. Moreover, AFB1 above 230 ppb reduced the bone volume and tissue volume of the cortical bone of femur. Even at levels above 75 ppb, AFB1 exposure significantly downregulated the jejunal mRNA expressions of the vitamin D receptor and calcium and phosphorus transporters. It can be concluded that AFB1 at levels higher than 230 ppb negatively affects bone health by impairing bone mineralization via disruption of the vitamin D receptor and calcium and phosphorus homeostasis, potentially contributing to bone health issues in broilers.

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Section: Methodsmentioning

confidence: 99%

Aflatoxin B1 Impairs Bone Mineralization in Broiler Chickens

Paneru,

Sharma,

Shi

et al. 2024

Toxins

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“… Adedokun et al (2016) reported that phytase supplementing at 5,000 FTU/kg in Eimeria infected birds resulted in higher feed efficiency, restored dry matter and energy digestibility to the levels of control birds. Shi et al (2022) found that supplementing phytase at 1,500 FTU/kg mitigated the negative effects on growth performance, bone mineralization, and apparent ileal digestibility of phytate of broilers with coccidial vaccine. In contrary, Shaw et al (2011) reported that no effect of 500 FTU/kg of phytase supplementation on performance or P utilization in broilers vaccinated, or coccidiosis infected, or both.…”

Section: Introdcutionmentioning

confidence: 94%

“…This leads to a poor growth performance and feed efficiency of broilers ( Woyengo and Nyachoti, 2013 ; Wang and Kim, 2021 ). Application of phytase has been shown to combat the negative effect of phytic acid, thus to improve growth performance ( Shang et al, 2015 ), nutrient utilization ( Cowieson et al, 2017 ; Shi et al, 2022 ), and bone mineralization ( Wang et al, 2019a , 2021 ). Besides, phytase has been shown to compensate for dietary protein, essential amino acid, and metabolizable energy deficiencies ( Namkung and Leeson, 1999 ).…”

Section: Introdcutionmentioning

confidence: 99%

Impacts of phytase and coccidial vaccine on growth performance, nutrient digestibility, bone development, and intestinal gene expression of broilers fed a nutrient reduced diet

Shi,

Wang,

White

et al. 2023

Poultry Science

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“…On the other hand, the intestine is considered the largest immune organ that is constantly encountering challenges [ 170 ]. As seen in multiple previous studies [ 171 , 172 , 173 ], the disturbance of the immune system caused by enteric diseases such as coccidiosis and enteric enteritis leads to the occurrence and development of bone disorders [ 11 , 169 ]. This process is once more propelled by the imbalance between osteoblast and osteoclast activities triggered by the upregulation of RANKL, which is induced by cytokines released from activated immune cells [ 174 , 175 ].…”

Section: Methionine and Arginine In Bone Healthmentioning

confidence: 99%

The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review

Liu,

Kim

2023

Animals

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This review explores the roles of methionine and arginine in promoting the well-being of poultry, with a specific focus on their impacts on intestinal and bone health. The metabolic pathways of methionine and arginine are elucidated, highlighting their distinct routes within the avian system. Beyond their fundamental importance in protein synthesis, methionine and arginine also exert their functional roles through their antioxidant capacities, immunomodulating effects, and involvement in the synthesis of metabolically important molecules such as S-adenosylmethionine, nitric oxide, and polyamines. These multifaceted actions enable methionine and arginine to influence various aspects of intestinal health such as maintaining the integrity of the intestinal barrier, regulating immune responses, and even influencing the composition of the gut microbiota. Additionally, they could play a pivotal role in promoting bone development and regulating bone remodeling, ultimately fostering optimal bone health. In conclusion, this review provides a comprehensive understanding of the potential roles of methionine and arginine in intestinal and bone health in poultry, thereby contributing to advancing the nutrition, overall health, and productivity of poultry in a sustainable manner.

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Effects of phytase and coccidial vaccine on growth performance, nutrient digestibility, bone mineralization, and intestinal gene expression of broilers

Cited by 17 publications

References 89 publications

Aflatoxin B1 Impairs Bone Mineralization in Broiler Chickens

Aflatoxin B1 Impairs Bone Mineralization in Broiler Chickens

Impacts of phytase and coccidial vaccine on growth performance, nutrient digestibility, bone development, and intestinal gene expression of broilers fed a nutrient reduced diet

The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review

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