Effects of Phytoestrogens on Depressive Symptoms in Climacteric Women: A Meta-Analysis of Randomized Controlled Trials

Su, Belinda Yuh-Wen; Tung, Tao‐Hsin; Chien, Wu-Hsiung

doi:10.1089/acm.2017.0118

Cited by 12 publications

(11 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Phytoestrogens are compounds with estrogen-like properties naturally found in plants [ 7 , 10 , 11 ]. Among flavonoids, isoflavones are the subclass with the highest phytoestrogen effect [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women

et al. 2021

View full text Add to dashboard Cite

The menopausal transition can be a challenging period for women’s health and a trigger of uncomfortable symptoms. Beer is the main food source of isoxanthohumol, a precursor of 8-prenylnaringenin, the strongest phytoestrogen identified to date. As phytoestrogens are reported to reduce perimenopausal symptoms, we evaluated if a daily moderate consumption of beer with (AB) and without alcohol (NAB) could improve menopausal symptoms and modify cardiovascular risk factors. A total of 37 postmenopausal women were enrolled in a parallel controlled intervention trial and assigned to three study groups: 16 were administered AB (330 mL/day), 7 NAB (660 mL/day), and 14 were in the control group. After a 6-month follow-up of the 34 participants who finished the trial, both interventions (AB and NAB) significantly reduced the severity of the menopause-related symptoms (p-value AB vs. Control: 0.009; p-value NAB vs. Control: 0.033). Moreover, AB had a beneficial net effect on psychological menopausal discomforts compared to the control group. As the sex hormone profile did not differ significantly between the study groups, the effects of both types of beers (AB and NAB) are attributed to the non-alcoholic fraction of beer. Furthermore, moderate NAB consumption improved the lipid profile and decreased blood pressure in postmenopausal women.

show abstract

Section: Introductionmentioning

confidence: 99%

Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The most commonly used herbal therapies are phytoestrogen supplements enriched with standardized soy-extracts or soy-isoflavones. Phytoestrogens are biologically active plant-derived compounds that are similar in chemical structure to 17β-estradiol and mimic estrogen-like properties [7]. Among the phytoestrogens, isoflavones and lignans are commonly used to relieve menopausal symptoms, as they are abundant in fruits, vegetables, legumes, and soy [8,9].…”

Section: Introductionmentioning

confidence: 99%

Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

et al. 2019

View full text Add to dashboard Cite

Plant-derived compounds have recently attracted greater interest in the field of new therapeutic agent development. These compounds have been widely screened for their pharmacological effects. Polyphenols, such as soy-derived isoflavones, also called phytoestrogens, have been extensively studied due to their ability to inhibit carcinogenesis. These compounds are chemically similar to 17β-estradiol, and mimic the binding of estrogens to its receptors, exerting estrogenic effects in target organs. Genistein is an isoflavone derived from soy-rich products and accounts for about 60% of total isoflavones found in soybeans. Genistein has been reported to exhibit several biological effects, such as anti-tumor activity (inhibition of cell proliferation, regulation of the cell cycle, induction of apoptosis), improvement of glucose metabolism, impairment of angiogenesis in both hormone-related and hormone-unrelated cancer cells, reduction of peri-menopausal and postmenopausal hot flashes, and modulation of antioxidant effects. Additionally, epidemiological and clinical studies have reported health benefits of genistein in many chronic diseases, such as cardiovascular disease, diabetes, and osteoporosis, and aid in the amelioration of typical menopausal symptoms, such as anxiety and depression. Although the biological effects are promising, certain limitations, such as low bioavailability, biological estrogenic activity, and effects on target organs, have limited the clinical applications of genistein to some extent. Moreover, studies report that modification of its molecular structure may eliminate the biological estrogenic activity and its effects on target organs. In this review, we summarize the potential benefits of genistein on menopause symptoms and menopause-related diseases like cardiovascular, osteoporosis, obesity, diabetes, anxiety, depression, and breast cancer.

show abstract

“…Fitoestrogênios como a agatisflavona, são compostos naturais presente nas plantas que podem fornecer uma alternativa aos estrogênios, sendo obtido os benefícios mas não os riscos da terapia hormonal, uma vez que o uso de terapias com estrogênio é limitada, devido ao aumento do risco de tumores dependentes de estrogênio (Su, Tung, & Chien, 2018). Research, Society and Development, v. 9, n. 12, e28291211061, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i12.11061…”

Section: Agatisflavonaunclassified

O estresse oxidativo e a neuroinflamação nas doenças neurodegenerativas: possível efeito neuroprotetor da agatisflavona

Júnior

Pimenta

Oliveira

2020

RSD

View full text Add to dashboard Cite

O estresse oxidativo e a neuroinflamação veem ganhando destaque como fatores contribuintes essenciais nas doenças neurodegenerativas. Nesse contexto os flavonoides possuem potentes propriedades anti-inflamatórias e antioxidantes que podem servir de terapia nestas doenças. Um representante deste grupo é o biflavonóide, agatisflavona, que em diversos estudos vem demonstrando ações biológicas que merecem atenção para a indústria farmacêutica na terapia das doenças neurodegenerativas. Através de uma revisão sistemática da literatura, analisou-se as publicações cientificas/experimentais publicadas entre 2011 e 2020, nas bases de dados da PubMed e ScienceDirect, com o objetivo de sistematizar os achados importantes sobre a agatisflavona que possam contribuir para sua abordagem terapêutica. Foram extraídos dados de 11 estudos que documentaram ações terapêuticas importantes que podem auxiliar no tratamento de doenças neurodegenerativas, como: atividade anti-inflamatória, imunomoduladora, indução de neurogênese, neutralização de radicais livres, neuroproteção e redução da morte neuronal. A partir dos dados obtidos, foi observado que agatisflavona possui características promissoras para atuar como um neuroprotetor adjuvante para o tratamento de doenças neurodegenerativas, contudo faz-se necessário mais estudos aprofundados e específicos, para que seu valor terapêutico seja evidenciado.

show abstract

Effects of Phytoestrogens on Depressive Symptoms in Climacteric Women: A Meta-Analysis of Randomized Controlled Trials

Cited by 12 publications

References 7 publications

Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women

Moderate Consumption of Beer (with and without Ethanol) and Menopausal Symptoms: Results from a Parallel Clinical Trial in Postmenopausal Women

Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

O estresse oxidativo e a neuroinflamação nas doenças neurodegenerativas: possível efeito neuroprotetor da agatisflavona

Contact Info

Product

Resources

About