2002
DOI: 10.1161/01.cir.0000016292.14390.16
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Effects of Pinacidil on Electrophysiological Properties of Epicardial Border Zone of Healing Canine Infarcts

Abstract: Background-K ATP channels, activated by ischemia, participate in the arrhythmogenic response to acute coronary occlusion. The function of these channels in border zones of healing infarcts, where arrhythmias also arise, has not been investigated. Do these channels remain maximally activated during infarct healing, or do they downregulate after a period of time? Both might preclude further activation. Methods and Results-Myocardial infarction was produced in dogs by ligation of the left anterior descending coro… Show more

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Cited by 16 publications
(10 citation statements)
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“…The beneficial effects of nicorandil were abolished after adding glibenclamide, indicating that these effects were achieved via the activation of K ATP channel. Our results were consistent with the findings of Coromilas et al [22], showing that K ATP channels remain functional after infarction and can be activated by K ATP channel agonists.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…The beneficial effects of nicorandil were abolished after adding glibenclamide, indicating that these effects were achieved via the activation of K ATP channel. Our results were consistent with the findings of Coromilas et al [22], showing that K ATP channels remain functional after infarction and can be activated by K ATP channel agonists.…”
Section: Discussionsupporting
confidence: 93%
“…Our results were consistent with the findings of Coromilas et al . , showing that K ATP channels remain functional after infarction and can be activated by K ATP channel agonists. Nicorandil can modify macrophages from an M1 to an M2 phenotype through a ROCK‐dependent pathway. The result was consistent with recent studies, showing that ROCK signalling can modulate polarization of macrophages .…”
Section: Discussionmentioning
confidence: 99%
“…Cardiomyocyte sizes, cardiac fibrosis, and echocardiographically derived LVESD and LVEDD were significantly smaller in either the pinacidil-or nicorandil-treated group than those in the vehicle. Our results were consistent with the findings of Coromilas et al (22), showing that K ATP channels at the border zone remain functional and can be activated by K ATP channel agonists. The involvement of K ATP channels is further supported by the antagonizing action of glibenclamide.…”
Section: Discussionsupporting
confidence: 93%
“…11 After at least 2 sequential beats of the VT had been mapped and the location of the reentrant pathway determined (Figure 1), the location of the line of block that formed during the tachycardia was carefully marked on a transparent electrode grid. The size and location of the central and outer pathways were noted, and the heart was removed.…”
Section: Methodsmentioning
confidence: 99%