Effects of piperine on testis of albino rats

Malini, T.; Manimaran, R.R; Arunakaran, J.; Aruldhas, M. M.; Govindarajulu, P.

doi:10.1016/s0378-8741(98)00128-7

Cited by 61 publications

(70 citation statements)

References 23 publications

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“…Several studies have related tubular diameter and length, as well as the seminiferous epithelium height and the tubular proportion within the parenchyma to the daily sperm production. The intraperitoneal injection of alcoholic extracts of Momordica charantia (Naseem et al, 1998), and piperine (Malini et al, 1999) in rats led to a reduction of the tubular diameter, thus reducing sperm production by severe modifi cations of the epithelium. On the other hand, Chieregatto (2005) reported that after treating rats with Anemopaegma arvense infusion, it was possible to increase those parameters, while not increasing the total tubular volume within the parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages

et al. 2011

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The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion. Therefore, the present study was designed to analyze whether the association of the plant infusion and endurance exercise could potentiate the stimulating effect. The animals were separated into 4 groups: two control (sedentary and trained) receiving water and two treated (sedentary and trained) receiving the plant infusion daily (104mg/day). The proportion of the seminiferous tubule compartment and interstitium was analyzed. Within the seminiferous epithelium, the number of Sertoli and germ cells were counted in order to evaluate whether the treatment would alter the spermatogenic dynamics, analyzing: the spermatogenic yield, the mitotic and meiotic indexes, the total number of germ cells and the Sertoli cell support capacity. Trained and treated animals showed increased spermatogenic yield and spermatogonia mitosis, and no signifi cant differences in apoptotic indexes. Despite the results showing the same pattern regarding yield and mitotic index, the meiotic index was higher in the sedentary/treated group. Therefore, the H. aphrodisiaca infusion increased both the testosterone production and the spermatogonia mitosis, thus increasing the spermatogenic yield.

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Section: Discussionmentioning

confidence: 99%

Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages

et al. 2011

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“…There has also been dicussion of the role of piperine in preventing oxidative alterations by carcinogens in intestinal mucosa [18]. Also, piperine is known to cause partial degeneration of germ cells of rats [19]. However, there are no published results on the analysis of piperine and its isomers in low concentrations from egg yolk or from complex matrices such as blood and cells.…”

Section: Introductionmentioning

confidence: 99%

Characterization and determination of piperine and piperine isomers in eggs

Ternes¹,

Krause²

2002

Analytical and Bioanalytical Chemistry

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A new analytical method for the determination of piperine and its isomers in egg yolk and albumen is described here. All four isomers were separated by HPLC and detected using UV, DAD and electrochemical detection. The absolute detection limit (UV detection, S/ N=3) of a standard solution of piperine was 370 pg piperine. The correlation coefficients for the linear calibration graphs (concentration range: c=100 ng-10 micro g piperine isomer/mL) are generally better than 0.996. The piperine isomers were characterized and identified by spectroscopy (MS, (1)H-NMR, FT-IR). The method was successfully applied to the determination of piperine deposits in eggs (egg yolk and albumen) after feeding hens with piperine-spiked feed. The detection limit for piperine (24.8(+/-0.2) ng/g egg yolk and 37.9(+/-4.9) ng/g albumen) and the recoveries (70.3(+/-7.7)% (egg yolk) and 75.7(+/-1.9)% (albumen)) of piperine were determined.

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“…A suplementação de piperina promove atividade antiparasitária (GHOSHAL et al, 1996), antipirética, analgésica (PARMAR et al, 1997), anti-inflamatória (GUPTA et al, 2000, contraceptiva, antiespermatogênica (MALINI et al, 1999), antioxidante (MITTAL & GUPTA, 2000), inseticida (PARMAR et al, 1997;ESTRELA et al, 2003), imunomoduladora (SUNILA & KUTTAN, 2004), anticarcinogênica (PRADEEP & KUTTAN, 2002;SELVENDIRAN et al, 2004;SUNILA & KUTTAN, 2004) e quimioprotetora (PATHAK & KHANDELWA, 2007). Além disso, a piperina aumenta a biodisponibilidade de algumas substâncias; ela inibe a biotransformação hepática e intestinal de certas drogas como no caso do curcumin (SHOBA et al, 1998), do propanolol e da theofilina (BANO et al, 1991) e de outras drogas e outros suplementos nutritivos.…”

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Administração oral de piperina em frangos de corte

Cardoso

Lima

et al. 2008

Cienc. Rural

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Effects of piperine on testis of albino rats

Cited by 61 publications

References 23 publications

Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages

Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages

Characterization and determination of piperine and piperine isomers in eggs

Administração oral de piperina em frangos de corte

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