Effects of plant- and animal-based high-fat diets on lipid storage and distribution in environmental bacteria-colonized gnotobiotic mice

Chen, Yi Hsun; Chiu, Chien Chao; Hung, Shao Wen; Liu, Ju Yun; Wang, Yu-Chih; Lv, Qiang; Hsu, Cheng Chih; Huang, Yi Wen; Huang, Wen Ching; Chuang, Hsiao-Li; Chen, Ter Hsin

doi:10.1016/j.bbrc.2017.09.079

Cited by 2 publications

(2 citation statements)

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“…This study, guided by previous reports and our recent study (Tan et al, 2014; Campbell et al, 2016; Chen et al, 2016, 2017), was designed to investigate the effects of microbes on exercise physiology using a gnotobiotic animal model. Few studies in the literature have examined the effects of individual/single microbes on exercise performance, training physiological adaption, energy expenditure, behaviors, and pathology.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effects of Microbiota on Exercise Physiological Adaption, Performance, and Energy Utilization Using a Gnotobiotic Animal Model

et al. 2019

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The wide diversity in gut microbiota that is found among individuals is affected by factors including environment, genetics, dietary habits, and lifestyle after birth. The gastrointestinal tract, the largest and most complicated in vivo ecosystem, is a natural habitat for microbe colonization. Gut microbiota acts as “metabolic organ” that interacts with the human host symbiotically and performs an important role in maintaining health. In addition to the above factors, microbiota distributions/proportions are affected by exercise and other forms of physical activity. However, diet, lifestyle, and nutritional supplementation may impede the actual analytic relationship in practice. Therefore, the purpose of this study is to understand the effects of several microbiota on physical fitness, exercise performance, energy metabolism, and biochemistries using the concept of gnotobiote based on a germ-free model. The microbes Eubacterium rectale, Lactobacillus plantarum TWK10, and Clostridium coccoides were separately inoculated into gnotobiotic animal models. Fecal analysis was regularly done for the entire duration of the experiment. The exercise capacities were measured repeatedly with and without aerobic exercise training using an exhaustive swimming test. Various fatigue-associated biochemical variables, including lactate, ammonia, glucose, lactic dehydrogenase (LDH), and creatine kinase (CK) were also measured to assess physiological adaption. In addition, metabolic phenotype was applied to record basal metabolic rate, diet, behavior, and activities. Body composition, glycogen content, and histopathology were further evaluated to assess the gnotobiotic effects. E. rectale engendered capacities, physiological adaption, and physical activities that were significantly better than other two microbes, possible due to energy regulation and bioavailability. In addition, L. plantarum TWK10 and C. coccoides were found to significantly increase the basal metabolic rate and to alter the body compositions, although no exercise capacity benefit was found in the gnotobiotic models. The E. rectale and L. plantarum gnotobiotic animals all showed normal histological observations with the exception of the C. coccoides gnotobiote, which showed the pathological observation of hepatic necrosis. The gnotobiotic model directly demonstrates the interactions between microbes and hosts, which are especially relevant and applicable to the field of sports science. This study supports the development of beneficial microbiota for application to exercise and fitness, which is an emerging area of health promotion.

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Section: Introductionmentioning

confidence: 99%

Investigation of the Effects of Microbiota on Exercise Physiological Adaption, Performance, and Energy Utilization Using a Gnotobiotic Animal Model

et al. 2019

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“…The interaction of endogenous bacteria does not seem to be very stringent, therefore, nitrogen-fixing endophytes could widely colonize in plant hosts (Chen et al, 2017). This feature makes it possible to play a special value on the study of endophytic bacteria and model plants, but it can also be applied to crop plants.…”

Section: The Ability Of Endophytic Bacteria On Nitrogen Fixationmentioning

confidence: 99%

The Role of Soil Microbes in Promoting Plant Growth

Li¹,

Peng²,

Liu³

et al. 2017

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More and more food is needed all over the world in order to meet rapidly growing population demands, while the modern agriculture on increasing output has already reached its limit. It is badly in need to cultivate new crop varieties for increase the yield and resistant to environmental stress and insects. However, crops are still need to provide the necessary fertilizer nutrients which is insufficient in soil. Recently, many evidences showed that soil microbes provide an opportunity for reducing agricultural demand in inorganic fertilizer. Microorganisms, due to their huge gene pool, are also used for a potential resource in biochemical reactions, which recycle nutrients for plant growth. Therefore, we need to modify and better use of soil microbiota to promote plant growth. In this review, we mainly summarized the role of soil microbiota by explaining the ecological balance, nitrogen fixation, nutrient elements, interactions and communication medium.

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Effects of plant- and animal-based high-fat diets on lipid storage and distribution in environmental bacteria-colonized gnotobiotic mice

Cited by 2 publications

References 38 publications

Investigation of the Effects of Microbiota on Exercise Physiological Adaption, Performance, and Energy Utilization Using a Gnotobiotic Animal Model

Investigation of the Effects of Microbiota on Exercise Physiological Adaption, Performance, and Energy Utilization Using a Gnotobiotic Animal Model

The Role of Soil Microbes in Promoting Plant Growth

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