Effects of Plant Extracts on Dentin Bonding Strength: A Systematic Review and Meta-Analysis

Zhao, Shikai; Hua, Fang; Yan, Jiarong; Yang, Hongye; Huang, Cui

doi:10.3389/fbioe.2022.836042

Cited by 4 publications

(2 citation statements)

References 77 publications

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“…However, GA has strong cytotoxicity and its clinical application is limited ( Cilli and Prakki, 2009 ; Cai et al, 2018 ). Therefore, natural polyphenolic cross-linking agents derived from plants have attracted more and more attention due to their strong and low toxicity, such as proanthocyanidins (PA), epigallocatechin gallate (EGCG), etc ( Zhao et al, 2022 ). Studies have shown that naturally occurring polyphenolic compounds can interact with collagen fibers through phenolic hydroxyl and galloyl groups to form covalent, ionic, and hydrogen bonds.…”

Section: Introductionmentioning

confidence: 99%

Theaflavin −3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen

Chen,

Wei,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

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ObjectivesTo study the ability of theaflavin-3,3’-digallate (TF3)/ethanol solution to crosslink demineralized dentin collagen, resist collagenase digestion, and explore the potential mechanism.MethodsFully demineralized dentin blocks were prepared using human third molars that were caries-free. Then, these blocks were randomly allocated into 14 separate groups (n = 6), namely, control, ethanol, 5% glutaraldehyde (GA), 12.5, 25, 50, and 100 mg/ml TF3/ethanol solution groups. Each group was further divided into two subgroups based on crosslinking time: 30 and 60 s. The efficacy and mechanism of TF3’s interaction with dentin type I collagen were predicted through molecular docking. The cross-linking, anti-enzymatic degradation, and biomechanical properties were studied by weight loss, hydroxyproline release, scanning/transmission electron microscopy (SEM/TEM), in situ zymography, surface hardness, thermogravimetric analysis, and swelling ratio. Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy were utilized to explore its mechanisms. Statistical analysis was performed using one and two-way analysis of variance and Tukey’s test.ResultsTF3/ethanol solution could effectively crosslink demineralized dentin collagen and improve its resistance to collagenase digestion and biomechanical properties (p < 0.05), showing concentration and time dependence. The effect of 25 and 50 mg/ml TF3/ethanol solution was similar to that of 5% GA, whereas the 100 mg/mL TF3/ethanol solution exhibited better performance (p < 0.05). TF3 and dentin type I collagen are mainly cross-linked by hydrogen bonds, and there may be covalent and hydrophobic interactions.ConclusionTF3 has the capability to efficiently cross-link demineralized dentin collagen, enhancing its resistance to collagenase enzymatic hydrolysis and biomechanical properties within clinically acceptable timeframes (30 s/60 s). Additionally, it exhibits promise in enhancing the longevity of dentin adhesion.

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Section: Introductionmentioning

confidence: 99%

Theaflavin −3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen

Chen,

Wei,

Liang

et al. 2024

Front. Bioeng. Biotechnol.

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“…Cross-linking agents, like adhesives, increase the hardness of the HL collagen matrix as improved biomechanical properties of the dentin matrix increase resin-dentin bond durability (Cai et al, 2018). A previous meta-analysis evaluating the effects of plant extracts as a primer on dentin bonding strength demonstrated an improvement in the immediate bond strength of adhesive (Zhao et al, 2022). Nevertheless, whether collagen cross-linkers can provide stable and long-lasting bonding strength to the adhesive interface is still debatable.…”

Section: Introductionmentioning

confidence: 99%

Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis

Chen

Sun

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: This study aimed to evaluate the role of collagen cross-linkers in the bonding performance of the resin-dentin interface through a systematic review and a network meta-analysis.Sources: The literature search was conducted in several databases like PubMed, EMBASE, Cochrane, Scopus and Web of Science from their inception till 30 April 2022.Study selection: The inclusion criteria consisted of in vitro studies evaluating the micro-tensile and micro-shear bond strengths of different cross-linkers acting on dentin. Bayesian network meta-analysis was conducted using RStudio.Data: Out of the 294 studies evaluated in the full-text analysis, 40 were included in the systematic review and meta-analysis. Most studies have used cross-linkers as primer (65.1%), followed by incorporating them into in adhesives and acid etching agents. The application methods of the adhesive system were classified as “etch-and-rinse (ER) adhesives” (77%) and “self-etching (SE) adhesives”. Moreover, there were six types of cross-linkers in this presented review, of which the most numerous were polyphenols.Conclusion: Different application methods of cross-linkers, the long-term results showed that were only effective when used for longer durations, the immediate results were not statistically different. According to immediate and long-term results, etch-and-rinse (ER) adhesives showed a greater bonding performance than the control groups (p ≤ 0.05), whereas self-etching (SE) adhesives showed similar bond strength values (p ≥ 0.05). The result of network meta-analysis (NMA) showed that Dope like compound showed higher long-term bonding performance than other cross-linkers.Clinical significance: Long-term clinical studies may be needed to determine the effect of the cross-linkers on the bonding properties.

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Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding

Enrich-Essvein,

González-López,

Rodríguez-Navarro

et al. 2024

Clin Oral Invest

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Objectives To evaluate the effect of proanthocyanidin-functionalized hydroxyapatite nanoparticles (nHAp_PA) used as pretreatment at different concentrations on the microtensile bond strength (µTBS) and endogenous enzymatic activity (MMPs) on pH-cycled dentin after 24 h and 6 months of artificial aging. Materials and methods Fifty human sound dentin blocks were randomly assigned to 5 groups (n = 10): (i) negative control (no treatment); (ii) positive control (pH-cycling); (iii) pH-cycling + 2% nHAp_PA for 60s; (iv) pH-cycling + 6.5% nHAp_PA for 60s; (v) pH-cycling + 15% nHAp_PA for 60s. A self-etch adhesive was used for bonding procedures before resin composite build-ups. Specimens were tested with the µTBS test after 24 h and 6 months of laboratory storage. The proteolytic activity in each group was evaluated with gelatin zymography and in situ zymography. Data were statistically analyzed (p < 0.05). Results At 24 h, the µTBS of the experimental groups were significantly higher than the controls (p ≤ 0.001), and no differences were observed between different concentrations (p > 0.05). Artificial aging significantly decreased bond strength in all groups (p ≤ 0.008); however, nHAp_PA 2% still yielded higher bonding values than controls (p ≤ 0.007). The groups pretreated with nHAp_PA exhibited lower MMP-9 and MMP-2 activities compared to the positive control group and almost the same enzymatic activity as the negative control group. In situ zymography showed that after 6 months of aging, nHAp_PA 2% and nHAp_PA 6,5% decreased enzymatic activity as well as the negative control. Conclusions Dentin pretreatment with nHAp_PA increased the bonding performance of a self-etch adhesive and decreased MMP-2 and MMP-9 activities after 6 months.

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Effects of Plant Extracts on Dentin Bonding Strength: A Systematic Review and Meta-Analysis

Cited by 4 publications

References 77 publications

Theaflavin −3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen

Theaflavin −3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen

Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis

Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding

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