Effects of plant sterols oncholesterol metabolism in man

Feedback Regulation of Metabolism by Dietary Constituents: Lipids

“…By feeding plant sterols and consequently reducing cholesterol absorption from the intestinal lumen, these authors demonstrated a net increase in cholesterol synthesis. Similar results on the release of feedback control have been obtained recently by Kudchodkar et al (29).…”

Effects of Sterylglycosides from Soybean on Lipid Indices in the Plasma, Liver, and Feces of Rats

“…l, because of the low level of supplemented dietary material. These findings are similar to those in the previous reports, [10][11][12][13][14][15] in which the level of plasma total cholesterol was generally reduced and a considerable part of the soybean sterols ingested was excreted into feces, this being accompanied by cholesterol excretion. The hypocholesterolemic effect of phytosterols is speculated to be attributable to their low absorbability and inhibitory action toward the absorption of intestinal cholesterol.…”

Effects of Stigmasterol-Supplemented Diets on Fecal Neutral Sterols and Bile Acid Excretion in Rats

“…These results agree with those reported in the literature [34,35], in the rat fed P-sitosterol. We can speculate that any fecal increase in cholesterol putput (just as it is or as coprostanol) might be metabolic consequences of: (1) its intestinal excretion [33], (2) inhibition of cholesterol absorption in the intestinal tract [13,36], (3) increase in intestinal microflora activity which converts cholesterol into coprostanol [37], and (4) the combination of all these factors.…”