Effects of Plasma Lipids on Fibrinolysis

Howell, Margaret

doi:10.1093/oxfordjournals.bmb.a070331

Cited by 24 publications

(5 citation statements)

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“…The results are, however, conflicting and today most authors believe that dietary ingestion of fat has no significant clinical effect on blood coagulation or fibrinolysis (14,16,18).…”

mentioning

confidence: 99%

Coagulation Studies after Administration of a Fat Emulsion, Intralipid®

Cronberg¹,

Nilsson²

1967

Thromb Haemost

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SummaryA single infusion of a fat emulsion, Intralipid®, used for parenteral nutrition was given to 11 healthy normals, 3 patients with von Willebrand’s disease and 3 with mild or moderately severe thrombasthenia. The infusion had no effect on coagulation or the fibrinolytic system. Platelet adhesiveness, as determined with Hellem’s whole blood method, was markedly increased but not with his plasma-ADP method or with Salzman’s method. No shortening of the bleeding time was observed in the normals or in the patients with prolonged bleeding time. The change observed in platelet adhesiveness is therefore believed to be an in vitro artefact with no clinical relevance.

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“…The results are, however, conflicting and today most authors believe that dietary ingestion of fat has no significant clinical effect on blood coagulation or fibrinolysis (14,16,18).…”

mentioning

confidence: 99%

Coagulation Studies after Administration of a Fat Emulsion, Intralipid®

Cronberg¹,

Nilsson²

1967

Thromb Haemost

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show abstract

“…[24,28,31]. In previous papers concerning the fibrinolytic system in patients with PCH we have reported on an increase of fibrinogen, proactivator-plasminogen, slow-reacting antiplasmin and in the in hibitors of plasminogen activation by urokinase, whereas PA activity was found to be decreased [28,29,30], The inhibition of PA release from the vessel wall is supposed by H ow ell [18] to be one of the points, where the plasminogen activation sequence is blocked by lipids. The purpose of the present study was to investigate the PA release following venous occlusion in patients with PCH.…”

Section: Enhancement Of the Fibrinolytic Activity By Venous Occlusionmentioning

confidence: 88%

“…The decreased fibrinolytic activity following venous occlusion in patients with PCH may be due to an inhibition of the PA release from the vessel wall by triglycerides, possibly in the way proposed by H o w e ll [18] and/or reduced contents of PA in the vessel wall in patients with PCH. Probably further investigations on the nature and behaviour of the 'post-occlusion' PA will elucidate this problem.…”

Section: Prc-occlusion Activator Level : Normal Persons (N-24)mentioning

confidence: 95%

Enhancement of the Fibrinolytic Activity by Venous Occlusion in Patients with Primary ‘Carbohydrate-Induced’ Hypertriglyceridemia

Spöttl¹,

Holzknecht²,

Braunsteiner³

1969

Acta Haematol

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“…In spite of numerous studies into the effects of plasma lipids upon fibrinolysis (5, 7,14), the importance of concomitant occurrence of hyperlipidaemia and reduced fibrinolysis for the development of thrombotic disease is still unclear. Therefore, in order to obtain further information about the possible relationship between reduced fibrinolytic capacity and various risk factors for atherosclerotic disease, co-operation has been established with the Oslo Study (1 1).…”

Section: Discussionmentioning

confidence: 99%