Effects of plasma parameters on increasing the purity of nitrogen atom encapsulated fullerene in an RF plasma

Ahamed, Jamal Uddin; Hatakeyama, Rikizo

doi:10.1016/j.mseb.2012.08.008

Cited by 1 publication

(1 citation statement)

References 19 publications

(25 reference statements)

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“…Furthermore, the formulation would be temperature sensitive and allow the release of chemotherapeutic drugs triggered by heat generated by fullerene under 13.56 MHz RF. 36,37 The fundamental requirement for receptor-mediated endocytosis into tumor cells in vivo is that the formulation extravasates from the blood circulation into the tumor tissue. Hence we follow the approaches and rely on shielded liposomal formulations that have been described to be long circulating and to extravasate based on the enhanced permeability and retention (EPR) effect.…”

Section: Introductionmentioning

confidence: 99%

Multi-functional liposomes showing radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy

Han

et al. 2015

Nanoscale

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Recently, nanoplatforms with multiple functions, such as tumor-targeting drug carriers, MRI, optical imaging, thermal therapy etc., have become popular in the field of cancer research. The present study reports a novel multi-functional liposome for cancer theranostics. A dual targeted drug delivery with radiofrequency-triggered drug release and imaging based on the magnetic field influence was used advantageously for tumor multi-mechanism therapy. In this system, the surface of fullerene (C60) was decorated with iron oxide nanoparticles, and PEGylation formed a hybrid nanosystem (C60-Fe3O4-PEG2000). Thermosensitive liposomes (dipalmitoylphosphatidylcholine, DPPC) with DSPE-PEG2000-folate wrapped up the hybrid nanosystem and docetaxel (DTX), which were designed to combine features of biological and physical (magnetic) drug targeting for fullerene radiofrequency-triggered drug release. The magnetic liposomes not only served as powerful tumor diagnostic magnetic resonance imaging (MRI) contrast agents, but also as powerful agents for photothermal ablation of tumors. Furthermore, a remarkable thermal therapy combined chemotherapy multi-functional liposome nanoplatform converted radiofrequency energy into thermal energy to release drugs from thermosensitive liposomes, which was also observed during both in vitro and in vivo treatment. The multi-functional liposomes also could selectively kill cancer cells in highly localized regions via their excellent active tumor targeting and magnetic targeted abilities.

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Section: Introductionmentioning

confidence: 99%

Multi-functional liposomes showing radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy

Han

et al. 2015

Nanoscale

View full text Add to dashboard Cite

show abstract

Effects of plasma parameters on increasing the purity of nitrogen atom encapsulated fullerene in an RF plasma

Cited by 1 publication

References 19 publications

Multi-functional liposomes showing radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy

Multi-functional liposomes showing radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy

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