1985
DOI: 10.1172/jci111865
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Effects of platelet-modifying drugs on arterial thromboembolism in baboons. Aspirin potentiates the antithrombotic actions of dipyridamole and sulfinpyrazone by mechanism(s) independent of platelet cyclooxygenase inhibition.

Abstract: To resolve questions of drug actions, efficacy, and interactions for platelet-modifying agents used clinically, we have compared the relative capacities and mechanisms of aspirin, dipyridamole, sulfinpyrazone, and dazoxiben to prevent arterial thromboembolism in a baboon model. In 136 studies the agents were given twice daily by oral administration both singly and in combination. The antithrombotic efficacy of a given therapy was determined by its capacity to interrupt steady-state platelet utilization induced… Show more

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Cited by 120 publications
(39 citation statements)
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“…ASA (32 mg/kg) was administered orally 2 to 4 hours before each thrombosis experiment, as described previously. 30 Four weeks were allowed for washout of each aXIMab and ASA before performing new experiments in the same animal. …”
mentioning
confidence: 99%
“…ASA (32 mg/kg) was administered orally 2 to 4 hours before each thrombosis experiment, as described previously. 30 Four weeks were allowed for washout of each aXIMab and ASA before performing new experiments in the same animal. …”
mentioning
confidence: 99%
“…In contrast, neither heparin (100 U/kg) nor aspirin (32.5 mg/kg twice daily) showed antithrombotic efficacy. At these doses, heparin has been shown to prevent the accumulation of morphologically identifiable amounts of fibrin onto vascular grafts (68), and aspirin has been shown to reduce the capacity of platelets to synthesize thromboxane A2 (TxA2) to < 1% of control values (47). Thus, in this setting ofacute arterial thrombosis associated with prosthetic vascular grafts, blocking the platelet GP IIb/IIIa receptor was substantially more effective than conventional therapies directed against coagulation-or thromboxane-mediated pathways of platelet recruitment.…”
Section: Discussionmentioning
confidence: 99%
“…A baboon animal was used in this study since this species is hemostatically similar to man with respect to coagulation factors, platelets and their granular contents, and immunologic characteristics of platelet and plasma proteins as studied using human radioimmunoassays (45)(46)(47)(48). The antithrombotic efficacy of injected antibody was assessed using a gamma scintillation camera to measure "'In-platelet deposition onto Dacron vascular grafts incorporated acutely into an externalized femoral arteriovenous shunt.…”
Section: Introductionmentioning
confidence: 99%
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