Effects of Platelet-Rich Plasma at the Cellular Level on Healing of Autologous Bone-Grafted Mandibular Defects in Dogs

Gérard, David; Carlson, Eric R.; Gotcher, Jack E.; Jacobs, Mykle

doi:10.1016/j.joms.2006.09.025

Cited by 44 publications

(29 citation statements)

References 34 publications

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“…Some studies have demonstrated that PRP enhances only the early healing of autogenous bone grafts. 11,33 Mandibular defects surgically created in dogs and treated with autogenous bone grafts combined with PRP presented a greater volume of new bone than defects treated with autogenous bone grafts at 4 and 8 weeks postoperative. However, this effect was no longer significant at 12 weeks postoperative.…”

Section: Discussionmentioning

confidence: 99%

Influence of the ratio of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: A histologic and histometric study in rat calvaria

et al. 2009

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The purpose of this study was to analyze histomorphometrically the influence of the ratio of particulate autogenous bone (AB) graft/platelet-rich plasma (PRP) on bone healing in surgically created critical-size defects (CSD) in rat calvaria. Fifty rats were divided into five groups: Group C (control), Group AB, Group AB/PRP-50, Group AB/PRP-100, and Group AB/PRP-150. A 5-mm diameter critical-size defect was created in the calvarium of each animal. In Group C, the defect was filled by blood clot only. In Group AB, the defect was filled with 0.01 mL of AB graft. In Groups AB/PRP-50, AB/PRP-100, and AB/PRP-150, the defects were filled with 0.01 mL of AB graft combined with 50, 100, and 150 mL of PRP, respectively. All animals were euthanized at 30 days postoperative. Histomorphometry, using image analysis software, and histology analyses were performed. New Bone Area (NBA) and the remaining bone graft particles area (RPA) were calculated as a percentage of the total area of the original defect. Percentage data were transformed into arccosine for analysis. No defect completely regenerated with bone. Group AB/PRP-50 (41.78 AE 13.48%) had a significantly greater NBA than Groups C (19.29 AE 5.11%), AB (27.43 AE 10.90%) or AB/PRP-150 (19.17 AE 8.45%) (p < 0.05). No significant differences were observed between groups AB/PRP-50 and AB/ PRP-100 or among groups AB, AB/PRP-100, and AB/PRP-150 with regard to NBA (p > 0.05). Group AB/PRP-150 (31.59 AE 3.22%) had a significantly greater RPA than Groups AB (19.09 AE 5.21%), AB/PRP-50 (17.33 AE 4.43%), and AB/PRP-100 (19.72 AE 3.62%) (p < 0.001). No significant differences were observed among groups AB, AB/PRP-50, and AB/PRP-100 with regard to RPA (p > 0.05). The ratio AB graft/PRP influences bone healing in surgically created CSD in rat calvaria. ß

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Section: Discussionmentioning

confidence: 99%

Influence of the ratio of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: A histologic and histometric study in rat calvaria

et al. 2009

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“…However, the effect of PRP on bone regeneration in in vivo studies is contradictory. New bone formation was detected in a PRP grafted canine model in the first 2 months (Gerard et al, 2006;Gerard et al, 2007). In contrast, PRP gel does not enhance the bone healing process in mandibular defects in rabbits (Kazakos et al, 2011).…”

Section: Introductionmentioning

confidence: 93%

Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study

Zhang¹,

Tangl²,

Huber³

et al. 2012

Journal of Cranio-Maxillofacial Surgery

186

172

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“…GERARD et al 9 effect in the early phase of bone healing. When PRP is processed from the patient's autologous blood, the risk of pathogen transmission is low.…”

Section: Discussionmentioning

confidence: 99%

Influence of platelet-rich plasma on ectopic bone formation of bone marrow stromal cells in porous coral

Zhang

Mao

Chen

2011

International Journal of Oral and Maxillofacial Surgery

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Effects of Platelet-Rich Plasma at the Cellular Level on Healing of Autologous Bone-Grafted Mandibular Defects in Dogs

Cited by 44 publications

References 34 publications

Influence of the ratio of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: A histologic and histometric study in rat calvaria

Influence of the ratio of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: A histologic and histometric study in rat calvaria

Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study

Influence of platelet-rich plasma on ectopic bone formation of bone marrow stromal cells in porous coral

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