Effects of Platelet Rich Plasma (PRP) in Treatment of Experimentally Induced Osteoarthritis in Rabbit’s Knee Joint

Kalbkhani, Morteza; Dehghani, S.; Najafpour, Alireza; Haddadi, Naji S.; Hossein, Kalbkhani Mohamad

doi:10.5171/2014.994022

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Animal studies commonly employ surgically induced osteoarthritis [ 124–126 ] followed by evaluating the effect of platelet products such as PRP, L-PRP [ 127 ] or PRF [ 128 ] in joints.…”

Section: Discussionmentioning

confidence: 99%

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An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

et al. 2017

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Aim:The aim of the study was to carry out a review of published studies on various platelet products in Iranian studies.Materials & methods:Electronic databases were searched for relevant articles. Two review authors independently extracted data via a tested extraction sheet, and disagreements were resolved by a meeting with a third review author.Results:Bone disorders (25%), wound and fistula (16%), dental and gingival disorders (14%) and osteoarthritis (11%) have more relative frequency based on different fields.Conclusion:The necessity of pursuing standard protocols in the preparation of platelet products, stating the precise content of platelets and growth factors, and long-term follow-up of study subjects were the most important points in Iranian studies.

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“…Animal studies commonly employ surgically induced osteoarthritis [ 124–126 ] followed by evaluating the effect of platelet products such as PRP, L-PRP [ 127 ] or PRF [ 128 ] in joints.…”

Section: Discussionmentioning

confidence: 99%

“…The study by Kalbkhani et al . on animal models [ 55 ] and Raeissadat et al . on the human knee [ 56 ] in 2013 were the first published papers in this field.…”

Section: Osteoarthritismentioning

confidence: 99%

An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

et al. 2017

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Effect of Different Treatments on Synovial Fluid Parameters in Experimental Osteoarthritis in Rabbits

Gorkava,

Malyuk

2023

Naukovì dopovìdì Nacìonalʹnogo unìversitetu bìoresursìv ì priro

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Veterinary specialists are actively studying the problem of osteoarthritis in animals (horses, dogs, cats, rabbits) and methods of overcoming it. At present, there are classical treatment regimens that give positive results, and the use of platelet-rich plasma (PRP) is being actively introduced into veterinary practice. In this regard, the studies described in this article were aimed at applying the effectiveness and evaluating changes in animals with experimental knee osteoarthritis of non-steroidal anti-inflammatory drugs in combination with chondroitin and glucosamine (classical treatment regimen) and platelet-rich plasma. The material of the study was synovial fluid obtained from animals with experimentally formed osteoarthritis of the knee joint on days 7, 14, 21 and 28 after the start of treatment using two different methods. In the animals of the experimental group (classical treatment regimen), on the 7th day, a decrease in the number of neutrophils by 31%, eosinophils by 12.5%, the number of lymphocytes increased by 31.3%, and macrophages decreased by 7% was observed. The number of lymphocytes increased by 7.3% compared to the baseline. On the 14th day, the number of neutrophils decreased by 61.5%, eosinophils by 45%, macrophages by 37.9%, and the number of lymphocytes increased by 4.5% compared to the 7th day. On the 21st day, the number of neutrophils decreased by 46.7%, eosinophils by 39.4%, macrophages by 51%, and the number of lymphocytes increased by 10.9% compared to the 14th day. On the 28th day, single neutrophils, eosinophils, and macrophages were observed in the synovial fluid samples, which corresponds to the physiological norm of synovial fluid composition. At the same time, the number of lymphocytes increased by 14.9% compared to the values of 21 days, but remained within the reference values. In animals treated with platelet-rich plasma on day 7, the number of neutrophils decreased by 54.7%, eosinophils by 33.7%, macrophages by 34% compared to the baseline, and the number of lymphocytes increased by 34% compared to the baseline. On the 14th day of the experiment, the number of neutrophils decreased by 60.5%, eosinophils by 37%, macrophages by 44.6%, and the number of lymphocytes increased by 10.5% compared to the 7th day, but were within the range of acceptable reference values. On day 21, single neutrophils, eosinophils, and macrophages were observed in the synovial fluid samples of animals of this group. It should be noted that the number of lymphocytes increased by 9.8 % compared to the values of day 14, which corresponds to the physiological norm of synovial fluid composition. On the 28th day of the experiment, single neutrophils and eosinophils were observed in the synovial fluid. At the same time, the number of lymphocytes increased by 19.5 % compared to day 21, which corresponds to the physiological norm of synovial fluid composition. The scientific material of experimental studies is of practical value for the use of platelet-rich plasma in the treatment of animals with osteoarthritis.

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Evaluating the Efficacy of Platelet-Rich Plasma in Treating Primary Knee Osteoarthritis: A Prospective Interventional Study

Gupta,

Jamra,

Prakash

et al. 2024

Cureus

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Introduction: Knee osteoarthritis (OA) is a prevalent degenerative joint disorder causing pain, stiffness, and reduced function, significantly impacting the quality of life. Current treatments mainly provide symptomatic relief, with limited efficacy in halting disease progression. Platelet-rich plasma (PRP), a biological therapy rich in growth factors, has gained attention as a potential treatment for knee OA due to its regenerative properties. This study evaluates the efficacy of PRP in managing primary knee OA. Methodology: This prospective interventional study included 100 patients diagnosed with primary knee OA, categorized using the Kellgren-Lawrence grading scale. Leukocyte-reduced PRP was prepared using the double-spin method and injected into the knee joint. The efficacy of PRP was assessed using the Western Ontario and McMaster Universities Arthritis (WOMAC) Index and Visual Analogue Scale (VAS) pain scores at six weeks, three months, and six months post-injection. Statistical analysis was performed using SPSS version 25.0, with significance set at p<0.05. Results: Significant improvements in the WOMAC and VAS scores were observed at all-time points post-PRP injection. The WOMAC score decreased from a baseline of 81.06 to 63.52 at six months (p < 0.001), and the VAS score reduced from 7.53 to 3.09 (p < 0.001). PRP was more effective in patients with lower body mass index (BMI) and less severe OA (Grades 1 and 2). Adverse events were mild, with 18% reporting mild pain or swelling. Conclusion: PRP therapy significantly improves pain and function in patients with primary knee OA, particularly in early-stage disease. The treatment is generally safe, with minor adverse effects. PRP presents a promising non-surgical option, especially for those seeking to delay or avoid knee arthroplasty.

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Effects of Platelet Rich Plasma (PRP) in Treatment of Experimentally Induced Osteoarthritis in Rabbit’s Knee Joint

Cited by 3 publications

References 16 publications

An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

An Overview of Platelet Products (PRP, PRGF, PRF, etc.) in the Iranian Studies

Effect of Different Treatments on Synovial Fluid Parameters in Experimental Osteoarthritis in Rabbits

Evaluating the Efficacy of Platelet-Rich Plasma in Treating Primary Knee Osteoarthritis: A Prospective Interventional Study

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