Effects of pluronic silica nanoparticles on the photophysical and photodynamic therapy behavior of triphenyl-p-phenoxy benzoic acid metalloporphyrins

Porphyrins Encapsulated into Pluronic F127 Micelles: Evaluating the Effect of the Central Metal and Substituents on the Photophysicochemical Properties in Water

“…All other reagents and solvents were obtained from commercial suppliers and used as received. The syntheses of metal free 5-(4-carboxyphenyl)-10,15,20-tris(phenyl) porphyrin (1-H 2 ) and its ClGa derivative (1-ClGa), [15] and metal free 5-(4-(4-carboxyphenoxy)phenyl)-10,15,20-tris(phenyl)porphyrin (2-H 2 ) and its ClGa, Zn and Si derivatives (2-ClGa, 2-Zn, 2-Cl 2 Si), [13] Figure 1, have been reported.…”

“…The porphyrins become water soluble after incorporation into Pluronic dissolved in organic solvents and when they are embedded in micelles since different solvents are used. Also comparison with carboxylic acid porphyrins linked to Pluronic silica nanoparticles [13] or linked to δ-aminolevulinic acid [15] is not possible since the reported work was done in organic media while this work is done on porphyrins is aqueous media.…”

“…It has been reported in literature [30] that an increase in Ф △ values is expected when porphyrins are incorporated into Pluronic polymers, however the results previously reported are incomparable as they were carried out in DMF. [13,15] According to literature, [8] the PEO segment of the polymer may hinder collision of the porphyrin with surrounding molecules thus obstructing idle losses of the triplet state energy therefore increasing Ф △ . Comparing 1-H 2 +F127 with 2-H 2 +F127 both metal free, but containing different substituents shows that the latter gave larger Ф △ value.…”

“…Complexes 2 have been linked to Pluronic-silica nanoparticles for PDT applications in organic media. [13] In this work these complexes are embedded in Pluronic 127 micelles for the first time. Study of porphyrins in aqueous media is essential for applications in biological systems such as in PDT.…”

Photophysicochemical properties and photodynamic therapy activity of chloroindium(III) tetraarylporphyrins and their gold nanoparticle conjugates

“…Photodynamic therapy (PDT) has emerged as a noninvasive clinical treatment modality for cancer which is a promising alternative to conventional cancer treatment protocols such as radiotherapy, chemotherapy and surgery that are known for their harmful side effects including the indiscriminate destruction of both healthy and tumor cells [1][2][3][4][5]. A prerequisite requirement for PDT is a light absorbing chromophore known as a photosensitizer (PS).…”