Effects of pollen and nasal glucocorticoid on FOXP3+, GATA‐3+ and T‐bet+ cells in allergic rhinitis

Malmhäll, Carina; Bossios, Apostolos; Pullerits, Teet; Lötvall, Jan

doi:10.1111/j.1398-9995.2007.01420.x

Cited by 52 publications

(46 citation statements)

References 29 publications

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“…GC inhibits histamine release from basophils [48,49], induces apoptosis of eosinophils [50] and reduces the recruitment of antigen-presenting cells such as Langerhans cells [51]. GC decreases the numbers of GATA-3 + Th2 cells and the production of Th2 cytokines, such as IL-4, IL-5, IL-6 and IL-13, while having little effect on T-bet + Th1 cells and the production of Th1 cytokines such as IL-2, IL-12 and interferon (IFN)-g [52,53]. Although the inhibitory effect of GC on B cell recruitment is limited, GC inhibits class-switching to IgE in the nasal mucosa [51,54].…”

Section: Cellular Level (Fig 2)mentioning

confidence: 99%

“…The ratio of FoxP3 + /GATA binding protein 3 (GATA-3 + ) cells in nasal mucosa was decreased significantly in patients with pollinosis as compared with healthy controls outside the pollen season, and the ratio was decreased further during the pollen season in allergic patients [53]. In addition, Tregs are induced in both peripheral blood and nasal mucosa following allergen-specific immunotherapy [68,69].…”

Section: Cd25mentioning

confidence: 99%

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Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Okano

2009

Clinical and Experimental Immunology

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SummaryAllergic rhinitis is a common airway disease characterized by hypersensitivity, exudation, hypersecretion, inflammatory cell infiltration and remodelling. Intranasal glucocorticosteroids are the most effective drugs for controlling the inflammation caused by allergic rhinitis. Glucocorticosteroids exert anti-inflammatory effects through at least two pathways: the transactivation pathway and the transrepression pathway. Glucocorticosteroids also exert regulatory functions by inducing regulatory cytokines and forkhead box P3 (FoxP3 + ) regulatory T cells. Evidence suggests that intranasal glucocorticosteroids control not only nasal symptoms but also ocular symptoms. In contrast to sedating H1 receptor antagonists, intranasal glucocorticosteroids can improve impaired performance symptoms, such as daytime sleepiness, associated with allergic rhinitis. Recent studies suggest that intranasal glucocorticosteroids might also be useful for the prophylactic treatment of pollinosis; this possibility is supported by the molecular mechanism of the anti-inflammatory action of glucocorticosteroids. These findings suggest that intranasal glucocorticosteroids might be positioned as first-line drugs for the treatment of both perennial and seasonal allergic rhinitis.

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Section: Cellular Level (Fig 2)mentioning

confidence: 99%

Section: Cd25mentioning

confidence: 99%

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Okano

2009

Clinical and Experimental Immunology

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“…These findings suggest that T-bet may be a negative regulator in allergic airway inflammation and airway hyperreactivity in both human beings and mice. Malmhäll et al [17] showed that similar levels of T-bet are present in the nasal mucosa in patients with AR and healthy controls, before and during the pollen season. However, a significant decrease in the T-bet + /GATA-3 + ratio was determined during the pollen season.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with AR, Malmhäll et al [17] demonstrated a higher number of FOXP3 + and GATA-3 + cells, but not T-bet + cells, in the nasal mucosa compared with that of healthy subjects before the start of the pollen season. Although, the number of FOXP3 + cells in the nasal mucosa remained the same in AR patients after the pollen season, it decreased significantly following treatment with fluticasone propionate.…”

Section: Discussionmentioning

confidence: 99%

Regulatory-T, T-Helper 1, and T-Helper 2 Cell Differentiation in Nasal Mucosa of Allergic Rhinitis with Olive Pollen Sensitivity

Söğüt¹,

Yılmaz²,

Kırmaz³

et al. 2011

Int Arch Allergy Immunol

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Background: Allergic rhinitis (AR) is a disease in which T-helper (Th)2 response is predominant and its pathogenic mechanism is still poorly understood. Aim: To evaluate the possible role of Th1, Th2 and regulatory-T (Treg) cells in the pathogenesis of AR. Methods: This case-control study enrolled 41 patients with seasonal AR (10–62 years old), sensitive to olive pollens, and 15 healthy controls (18–60 years old). Nasal biopsy was performed and specimens of nasal lavage fluid were obtained from all participants. The levels of interleukin (IL)-4, IL-10, interferon (IFN)-γ and transforming growth factor-β (TGF-β) were measured in nasal lavage fluid specimens. The expression of FOXP3, GATA-3 and T-bet was measured by immunohistochemical methods in the nasal biopsy specimens. Results: The levels of IFN-γ in the group with AR were significantly lower than those in the control group (p = 0.008). The levels of IL-4, IL-10 and TGF-β did not differ between the two groups. The expression of FOXP3 and T-bet in patients with AR was significantly lower than that in the control group (both p = 0.001). Expression of GATA-3 in the nasal mucosa was similar between the groups (p = 0.2). The ratios of T-bet/GATA-3 and FOXP3/GATA-3 in the AR group were significantly lower than those in the control group (p = 0.001). Conclusion: Insufficient Treg and Th1 cells may be associated with the allergic inflammation that may be attributed to the Th2 immune response in patients suffering from AR who are sensitive to olive pollen.

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“…[44][45][46] Analysis of transcription factor expression by using immunohistochemical techniques conflict with some studies that demonstrated FoxP3, T-box transcription factor (T-bet), and TGF-␤ expression to be lower in patients with AR than in controls with increased GATA-3 expression, 47,48 whereas another study found that FoxP3 and GATA-3 have elevated expression in patients with AR, at least during the preallergy season. 49 These discrepancies further highlighted the importance of investigating the functional fitness of Tregs to more accurately denote the functional significance of Treg infiltrates locally within tissues.…”

Section: Alterations In Treg Numbers and Functions In Ar And Crswnpmentioning

confidence: 99%

The Role of Regulatory T Cells in the Regulation of Upper Airway Inflammation

Palmer

Mulligan

Smith

et al. 2017

Am J Rhinol�Allergy

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Effects of pollen and nasal glucocorticoid on FOXP3⁺, GATA‐3⁺ and T‐bet⁺ cells in allergic rhinitis

Cited by 52 publications

References 29 publications

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Regulatory-T, T-Helper 1, and T-Helper 2 Cell Differentiation in Nasal Mucosa of Allergic Rhinitis with Olive Pollen Sensitivity

The Role of Regulatory T Cells in the Regulation of Upper Airway Inflammation

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