Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization

Abstract

Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and PAMAM@MBN. After soaking each sample in simulated body fluid (SBF), we observed ion-releasing effects and dentin remineralization effects for 30 days. Also, we prepared 30 premolars to find the ratio of occluded dentinal tubules after applying MBN and PAMAM@MBN, respectively. The results showed that PAMAM did not disrupt the calcium ion-releasing ability or the dentin remineralization of MBN. The PAMAM@MBN showed a better occluding effect for dentinal tubules than that of MBN (p < 0.05). In terms of dentinal tubule occlusion, the gap between MBN was well occluded due to PAMAM. This implies that PAMAM@MBN could be effectively used in dentinal tubule sealing and remineralization.

In Vitro Effect of Gallium-Doped Bioactive Glass on Enamel Anti-Demineralization and Bond Strength of Orthodontic Resins

“…Characterization of the GaMBN-containing resins confirmed that the Ga 3+ , Ca 2+ , and PO 4 3− ions formed the same heterogeneous structure as the previous study [18]. Moreover, the N 2 adsorption-desorption isotherm results determined that the resins have uniform pore structures (type IV isotherms) as shown in the previous study [17]. Ion release tests demonstrated that ions were barely released by GaMBN0, and that ion release increased with the GaMBN concentration.…”

“…The GaMBN was synthesized using the modified sol-gel process reported in a previous study [17]. First, 10 mL of 2-ethoxyethanol (Sigma-Aldrich, St. Louis, MO, USA), 2 mL of aqueous ammonia (Samchun, Pyeongtaek, South Korea), and 0.788 g of calcium nitrate tetrahydrate (Ca(NO 3 ) 2 •4H 2 O; Sigma-Aldrich, St. Louis, MO, USA) were added to 150 mL of distilled water along with 20 mL of ethanol and 1 g of hexadecyltrimethylammonium bromide (CTAB; Sigma-Aldrich, St. Louis, MO, USA).…”

Mesoporous Bioactive Glass Combined with Graphene Oxide Quantum Dot as a New Material for a New Treatment Option for Dentin Hypersensitivity

“…The absorption peaks at 1220-1250 cm −1 were attributed to C-OH, C-C stretching, and -OH bending vibrations [13]. As shown in Figure 4(b), the stretching frequency (1643 cm −1 ) corresponding to O-H also shifted to 1639 cm −1 due to the chemical bonds of GOQD and MBN in MBN@GOQD sample [13,24]. .…”

“…The weak peak at 562 cm −1 appears to be the P-O band of phosphate group. The peak of 874, 1424, and 1469 cm −1 appears to be the C-O band of calcium carbonate [13].…”

“…BAG releases calcium, sodium, and phosphate ions to raise the pH and create the precipitation of calcium phosphate and mineralization into hydroxyapatite [6][7][8][9][10]. Because of their buffering and apatite-forming abilities, BAG can be considered as great alternative for dentin hypersensitivity treatment [2,[11][12][13][14][15]. However, BAG, which covered dentinal tubule, appeared to be removed easily by chemical and physical stimuli [16].…”