Effects of Polycystic Ovary Syndrome (PCOS), Sex Hormones, and Obesity on Circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 Expression

Murri, Mora; Insenser, María; Fernández‐Durán, Elena; San-Millán, José L.; Escobar-Morreale, Héctor F.

doi:10.1210/jc.2013-2218

Cited by 153 publications

(126 citation statements)

References 43 publications

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“…Por lo que es probable que ambos miRNAs estén involucrados con la patogénesis del SOP. El segundo estudio realizado en sangre periféri-ca estableció que la expresión de miRNA-21, miR-NA-27b y miRNA-103, se encuentra aumentada en mujeres SOP obesas, mientras que en hombres y mujeres controles obesos están disminuidos 36 . El 22%, 11% y 13% de la variación en la expresión del miR-21, miR-27b y miR-103 se explica por un efecto negativo de la obesidad y positivo de las concentraciones libres de testosterona sérica.…”

Section: Micrornas En Sopunclassified

“…La obesidad produce una importante influencia en la expresión sérica de miRNA-21, miRNA-27b, miRNA-103, y miRNA-155, sin embargo, estos efectos son diferentes en las mujeres con SOP 36 . Estos miRNAs presentan el mismo patrón de cambio en mujeres y hombres obesos (disminuyen su expresión), pero en las mujeres con SOP y obesidad su expresión se ve aumentada 36 .…”

Section: Micrornas En Sopunclassified

“…Estos miRNAs presentan el mismo patrón de cambio en mujeres y hombres obesos (disminuyen su expresión), pero en las mujeres con SOP y obesidad su expresión se ve aumentada 36 . Esto podría deberse a que la obesidad ejerce una inhibición de la expresión de estos miRNAS, mientras que los niveles de testosterona libre epigenética del síndrome de ovario poliquístico -F. concha et al rev Med chile 2017; 145: 907-915 sérica potencian su expresión, y las mujeres con SOP obesas presentan niveles significativamente más altos de testosterona plasmática libre 31 .…”

Section: Micrornas En Sopunclassified

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Epigenética del síndrome de ovario poliquístico

Recabarren³

et al. 2017

Rev. méd. Chile

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Epigenetics of polycystic ovary syndromeE l síndrome de ovario poliquístico (SOP), es una disfunción endocrino-metabólica con una prevalencia de 6-10% en mujeres de edad reproductiva 1,2 . Se caracteriza por hiperandrogenismo, oligo-anovulación y morfología de ovario poliquística. Representa la causa más frecuente de infertilidad anovulatoria e hiperandrogenismo en mujeres. Además, la mayoría de las pacientes con SOP desarrollan resistencia insulínica periférica (RI) y poseen un mayor riesgo de desarrollar diabetes mellitus tipo 2 (DM2) 3 .Su etiología es multifactorial, y es tema de investigación relevante ya que el SOP se considera un desorden genético complejo, en donde numerosos genes contribuyen parcialmente al fenotipo sin que alguno de ellos constituya uno de riesgo mayor. El fenotipo es también influenciado por factores ambientales 4,5 , siendo finalmente la suma de ambos factores, la que gatilla el síndrome [6][7][8] . A esto debemos sumar la acción del ambiente, siendo finalmente la suma de ambos factores, los gatilladores del síndrome 7,8 . Se ha sugerido que existen factores genéticos implicados en el desarrollo del síndrome, debido a que se ha observado un fuerte componente de agregación familiar, siendo afectados entre 20-40% de los parientes de primer grado de las mujeres con SOP 9-12 . En los últimos años se ha propuesto que la programación fetal podría estar implicada en la patogenia del SOP. En este contexto la exposición prenatal a andrógenos (EPA) podría ser uno de los principales candidatos como factor reprogramador [13][14][15][16][17][18][19][20] . Independiente de la fuente del exceso de andrógenos prenatal, estas observaciones sugieren que el SOP podría ser programado in utero por la influencia del aumento de andrógenos e insulina, posiblemente mediante la alteración de la expresión génica durante la vida pre y post-natal.Esta revisión tiene por objetivo analizar la información disponible hasta el día de hoy relacionada a dos mecanismos de regulación epigenética como son las metilaciones del ADN y el papel de

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Section: Micrornas En Sopunclassified

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Epigenética del síndrome de ovario poliquístico

Recabarren³

et al. 2017

Rev. méd. Chile

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“…It is notable that miRNAs were related to several reproductive disorders, such as endometriosis (Carletti & Christenson 2009), poor ovarian response (Donadeu et al 2012) and, very recently, PCOS (Carletti & Christenson 2009, Hawkins & Matzuk 2010, Chen et al 2013, Hossain et al 2013, Murri et al 2013, Roth et al 2014, Xu et al 2015. Regarding PCOS, microarray profiling of human follicular fluid revealed that 29 miRNAs were differentially expressed between PCOS and fertile oocyte donors.…”

Section: Introductionmentioning

confidence: 99%

“…Pathway analysis revealed that target genes were involved in insulin regulation and inflammation (Roth et al 2014). miRNA-21, miRNA-27b, miRNA-103 and miRNA-155 were differentially expressed in the serum between PCOS and normal women (Murri et al 2013). It has been shown that miRNAs that play important roles in the metabolic and immune system processes are influenced by obesity and circulating androgen concentrations in PCOS patients.…”

Section: Introductionmentioning

confidence: 99%

Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8

Huang¹,

Liu²,

Hao³

et al. 2016

Reproduction

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Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women and is characterised by polycystic ovaries, hyperandrogenism and chronic anovulation. Although the clinical and biochemical signs of PCOS are typically heterogeneous, abnormal folliculogenesis is considered a common characteristic of PCOS. Our aim is to identify the altered miRNA and mRNA expression profiles in the cumulus cells of PCOS patients to investigate their molecular function in the aetiology and pathophysiology of PCOS. In this study, the miRNA expression profiles of the cumulus cell samples isolated from five PCOS and five control patients were determined by an miRNA microarray. At the same time, the altered mRNA profiles of the same cumulus cell samples were also identified by a cDNA microarray. From the microarray data, 17 miRNAs and 1263 mRNAs showed significantly different expression in the PCOS cumulus cells. The differentially expressed miRNA-509-3p and its potential target gene (MAP3K8) were identified from the miRNA and mRNA microarrays respectively. The expression of miRNA-509-3p was up-regulated and MAP3K8 was down-regulated in the PCOS cumulus cells. The direct interaction between miRNA-509-3p and MAP3K8 was confirmed by a luciferase activity assay in KGN cells. In addition, miRNA-509-3p mimics or inhibitor transfection tests in KGN cells further confirmed that miRNA-509-3p improved oestradiol (E 2 ) secretion by inhibiting the expression of MAP3K8. These results help to characterise the pathogenesis of anovulation in PCOS, especially the regulation of E 2 production.

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MicroRNA‐29‐mediated cross‐talk between metabolic organs in the pathogenesis of diabetes mellitus and its complications: A narrative review

Yesuf,

Molla,

Malik

et al. 2024

Cell Biochemistry & Function

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Diabetes mellitus (DM) is a heterogeneous group of disorders characterized by hyperglycemia. Microribonucleic acids (microRNAs) are noncoding RNA molecules synthesized in the nucleus, modified, and exported to the extracellular environment to bind to their complementary target sequences. It regulates protein synthesis in the targeted cells by inhibiting translation or triggering the degradation of the target messenger. MicroRNA‐29 is one of noncoding RNA that can be secreted by adipose tissue, hepatocytes, islet cells, and brain cells. The expression level of the microRNA‐29 family in several metabolic organs is regulated by body weight, blood concentrations of inflammatory mediators, serum glucose levels, and smoking habits. Several experimental studies have demonstrated the effect of microRNA‐29 on the expression of target genes involved in glucose metabolism, insulin synthesis and secretion, islet cell survival, and proliferation. These findings shed new light on the role of microRNA‐29 in the pathogenesis of diabetes and its complications, which plays a vital role in developing appropriate therapies. Different molecular pathways have been proposed to explain how microRNA‐29 promotes the development of diabetes and its complications. However, to the best of our knowledge, no published review article has summarized the molecular mechanism of microRNA‐29‐mediated initiation of DM and its complications. Therefore, this narrative review aims to summarize the role of microRNA‐29‐mediated cross‐talk between metabolic organs in the pathogenesis of diabetes and its complications.

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Effects of Polycystic Ovary Syndrome (PCOS), Sex Hormones, and Obesity on Circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 Expression

Abstract: The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations.

Cited by 153 publications

References 43 publications

Epigenética del síndrome de ovario poliquístico

Epigenética del síndrome de ovario poliquístico

Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8

MicroRNA‐29‐mediated cross‐talk between metabolic organs in the pathogenesis of diabetes mellitus and its complications: A narrative review

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