Effects of polyphenols and their metabolites on age-related diseases

Zhor, Chouari; Wafaa, Lounis; Ghzaiel, Imen; Kessas, Khadidja; Zarrouk, Amira; Ksila, Mohamed; Ghrairi, Taoufik; Latruffe, Norbert; Masmoudi-Kouki, Olfa; El Midaoui, Adil; Vervandier-Fasseur, Dominique; Hammami, Mohamed; Lizard, Gérard; Vejux, Anne; Kharoubi, Omar

doi:10.1016/j.bcp.2023.115674

Cited by 12 publications

(2 citation statements)

References 243 publications

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“…Therefore, foods high in polyphenols and other bioactive compounds, which have anti-inflammatory and antioxidant properties, may be used as “anti-senescence” or “senolytic” foods in a nutraceutical strategy for enhanced cellular longevity and better aging ( Gurau et al, 2018 ). Indeed, nutraceuticals rich in polyphenols have shown excellent results in many age-related diseases owing to their antioxidant and anti-inflammatory effects ( Zhor et al, 2023 ).…”

Section: Implications For Prevention and Treatment Of Age-related Dis...mentioning

confidence: 99%

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Salama,

Eissa,

Doghish

et al. 2024

Front. Aging

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MicroRNAs (miRNAs) are short RNA molecules that are not involved in coding for proteins. They have a significant function in regulating gene expression after the process of transcription. Their participation in several biological processes has rendered them appealing subjects for investigating age-related disorders. Increasing data indicates that miRNAs can be influenced by dietary variables, such as macronutrients, micronutrients, trace minerals, and nutraceuticals. This review examines the influence of dietary factors and nutraceuticals on the regulation of miRNA in relation to the process of aging. We examine the present comprehension of miRNA disruption in age-related illnesses and emphasize the possibility of dietary manipulation as a means of prevention or treatment. Consolidating animal and human research is essential to validate the significance of dietary miRNA control in living organisms, despite the abundance of information already provided by several studies. This review elucidates the complex interaction among miRNAs, nutrition, and aging, offering valuable insights into promising areas for further research and potential therapies for age-related disorders.

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Section: Implications For Prevention and Treatment Of Age-related Dis...mentioning

confidence: 99%

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Salama,

Eissa,

Doghish

et al. 2024

Front. Aging

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“…Tea's nutritional and therapeutic value stems from its unique blend of ingredients such as proteins, carbohydrates, amino acids, lipids, vitamins, minerals, alkaloids, and polyphenols 2 . It is a natural antioxidative agent capable of reducing a wide variety of ailments such as cancer and heart disease due to the presence of polyphenols and catechins 3 . As a result, tea appears to be a potent chemo preventive agent against toxic substances, free radicals, and carcinogens 4 .…”

Section: Introductionmentioning

confidence: 99%

Seasonal variations in the phenolic profile, antioxidant activity, and mineral content of south Indian black tea (Camellia sinensis (L.) O. Kuntze)

Govindasamy,

Sugumar,

Kandan

et al. 2023

Sci Rep

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In the Anamallais region of south India, crop shoots from the UPASI-3, UPASI-9, UPASI-17, Assam seedlings, and TRI-2043 cultivars were examined for seasonal variations in total phenolics, antioxidant activity, and minerals during four harvest seasons: summer (January to March), premonsoon (April and May), monsoon (June to September), and winter (October to December) of two consecutive years. The total phenolics of all cultivars were lower in monsoon period and grew over rest of the seasons and it was greater during summer. Crop shoot antioxidant activity as measured by the DPPH radical scavenging experiment exhibited a similar pattern to total phenolics. Summer was the season with the highest antioxidant activity across all cultivars, followed by premonsoon, winter, and monsoon. On the other hand, the employed cultivars differed noticeably in terms of seasonal change of minerals. These results appear to indicate that the harvest period is hypercritical in deciding the antioxidant potency of tea crop shoots.

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Advancing Osteoporotic Bone Regeneration Through Tailored Tea Polyphenols Functionalized Micro‐/Nano‐ Hydroxyapatite Bioceramics

Zhao,

Qian,

Zhu

et al. 2024

Adv Funct Materials

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Efforts to develop advanced bone substitutes for effective bone regeneration in substantial defects have led to the fabrication of tissue‐engineered scaffolds. These scaffolds, featuring hierarchical structures, specific chemical compositions, and functional qualities, are essential in mimicking native bone tissue. Inspired by the biomineralization process, hydrothermal treatment is used to synthesize micro‐/nano‐hydroxyapatite bioceramics functionalized with tea polyphenols (TP‐nwHA), closely resembling the structure of bone‐like apatite induced by hydroxyapatite bioceramics in vivo. The in vitro results demonstrate TP‐nwHA's superior biocompatibility, enhancing cell proliferation and adhesion. Furthermore, TP‐nwHA scaffolds significantly influence mesenchymal stem cells, promoting osteogenic differentiation while inhibiting osteoclastogenic differentiation. The upregulation of osteogenic proteins BMP2 and ITGB1, along with the downregulation of osteoclastic proteins FGF21 and IGFBP1, demonstrate the synergistic effect of the biomimetic structure and polyphenols on the activation of the MAPK signaling pathway. In vivo, TP‐nwHA showe early angiogenic capabilities, leading to improved bone regeneration in critical‐size femoral bone defects in osteoporotic rats. Histological staining confirms the complete bridging of defects with new bone tissue in the TP‐nwHA group, and nanoindentation tests indicate the formation of mature mineralized bone tissue. Collectively, these findings suggest a novel strategy for fabricating bone‐mimicking constructs with potential applications in disease modeling.

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Effects of polyphenols and their metabolites on age-related diseases

Cited by 12 publications

References 243 publications

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Seasonal variations in the phenolic profile, antioxidant activity, and mineral content of south Indian black tea (Camellia sinensis (L.) O. Kuntze)

Advancing Osteoporotic Bone Regeneration Through Tailored Tea Polyphenols Functionalized Micro‐/Nano‐ Hydroxyapatite Bioceramics

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