Effects of Polyvinyl Alcohol on Drug Release from Nanocomposite Particles Using Poly (L-lactide-&lt;i&gt;co&lt;/i&gt;-glycolide)

Takeuchi, Issei; Kato, Yuuto; Makino, Kimiko

doi:10.5650/jos.ess20299

Cited by 8 publications

(3 citation statements)

References 33 publications

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“… 46 Among versatile types of surfactant used in NSs preparation, it is clear that PVA is widely used with a significant impact on the stability and physical features of drug-loaded nanoparticles including nanospheres and/or nanocapsules. 18 , 46 , 47 GPS has hydrophobic nature with limited aqueous solubility. 26 Increasing PVA concentration in the external aqueous phase supports GPS molecules to be tightly incorporated into PLGA core and minimum diffusion out to the external phase leading to higher entrapment efficiency ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…Different literature showed that the effect of PVA on release profile is basically concentration-dependent. 47 , 48 GPS is tightly incorporated with inner PLGA core and insoluble in an aqueous phase containing lower concentrations of PVA, below that is required for micellar formation and/or solubilizing GPS, 46 resulting in suppressing the initial burst of GPS out to release medium parallel with neglected effect on the total % cumulative release after three days. 47 , 48 Typical spheres of GPS-loaded PLGA nanoformulations demonstrated by transmission electron micrographs ensure that emulsion solvent evaporation method utilizing probe sonication could be considered an accessible and optimum technique could produce core /shell nanosystem.…”

Section: Discussionmentioning

confidence: 99%

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Gentiopicroside PLGA Nanospheres: Fabrication, in vitro Characterization, Antimicrobial Action, and in vivo Effect for Enhancing Wound Healing in Diabetic Rats

Almukainzi

El‐Masry

Negm

et al. 2022

IJN

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Purpose Gentiopicroside (GPS), an adequate bioactive candidate, has a promising approach for enhancing wound healing due to its antioxidant and antimicrobial properties. Its poor aqueous solubility negatively affects oral absorption accompanied by low bioavailability due to intestinal/hepatic first-pass metabolism. Our aim in this study is to fabricate GPS into appropriate nanocarriers (PLGA nanospheres, NSs) to enhance its solubility and hence its oral absorption would be improved. Methods Normal and ODS silica gel together with Sephadex LH20 column used for isolation of GPS from Gentiana lutea roots. Crude GPS would be further processed for nanospheres fabrication using a single o/w emulsion solvent evaporation technique followed by in vitro optimization study to examine the effect of two formulation variables: polymer (PLGA) and stabilizer (PVA) concentrations on the physical characterizations of prepared NSs. Possible GPS-PLGA chemical and physical interactions have been analyzed using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The optimum GPS-PLGA NSs have been chosen for antimicrobial study to investigate its inhibitory action on Staphylococcus aureus compared with unloaded GPS NSs. Also, a well-designed in vivo study on streptozotocin-induced diabetic rats has been performed to examine the wound healing effect of GPS-PLGA NSs followed by histological examination of wound incisions at different day intervals throughout the study. Results The optimum GPS PLGA NSs (F5) with well-controlled particle size (250.10±07.86 nm), relative high entrapment efficiency (83.35±5.71), and the highest % cumulative release (85.79±8.74) have increased the antimicrobial activity as it exhibited a higher inhibitory effect on bacterial growth than free GPS. F5 showed a greater enhancing impact on wound healing and a significant stimulating effect on the synthesis of collagen fibers compared with free GPS. Conclusion These findings demonstrate that loading GPS into PLGA NSs is considered a promising strategy ensuring optimum GPS delivery for potential management of wounds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gentiopicroside PLGA Nanospheres: Fabrication, in vitro Characterization, Antimicrobial Action, and in vivo Effect for Enhancing Wound Healing in Diabetic Rats

Almukainzi

El‐Masry

Negm

et al. 2022

IJN

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“…On the basis of PVS, nanoparticles are also created that provide prolonged release of medicinal substances [21]. The effects of PVA on the release behavior of polymer nanoparticles from nanocomposite particles using amino acids were investigated [22]. PVA cross-linked microspheres are used in oral precision relief systems [23,24].…”

Section: Introductionmentioning

confidence: 99%

Prolonging effect of polyvinyl alcohol on the drug release

et al. 2022

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Polymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs. The purpose of this work was to assess the ability to prolong the action of polyvinyl alcohol in relation to the drug release when going from dilute to more concentrated solutions. It was established that an increase in the viscosity of the polymer in solution caused by an increase in its concentration results not only in a slowdown in the diffusion of drugs from the polymer solution, but also in a significant decrease in the amount of drugs firmly fixed on the polymer matrix. Since it is the adduct of the polyvinyl alcohol-drug interaction that provides the slow release of the drug from the polymer solution, a decrease in its amount leads to the fact that no enhancement of the prolonging action is observed. It is claimed that when moving from solutions to polymer films, the rate of drug release is also determined by the structure of the polymer matrix. The lower the density of the polymer film, the greater the diffusion coefficient of the drug release from the film. Thus, in the course of evaluating the ability to prolong the action of polyvinyl alcohol, it was shown that using some prolongation techniques, it is possible to achieve targeted regulation of the rate of drug release from polymer dosage forms.

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Development of Specially Designed Nanoparticle‐coated 3D‐printed Gelatin Methacryloyl Patches for Potential Tissue Engineering Applications

Bedir,

Baykara,

Sahin

et al. 2024

Macro Materials & Eng

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Tympanic membrane (TM) perforation is a serious ear discomfort that can cause hearing loss and make the middle ear vulnerable to infections. In this study, a unique TM patch is designed to mimic the structure of the natural eardrum for tissue engineering of TM perforations. Gelatin methacryloyl (GelMA)‐based TM patches are equipped with microneedles (MNs) to better adhere to the perforation site and developed using the digital light processing (DLP) based 3D printing technique. To impart biofunctionality to the 3D‐printed patches, their surfaces are coated with gentamicin (GEN) loaded poly(vinyl alcohol) (PVA) nanoparticles (NPs) using the Electrohydrodynamic Atomization (EHDA) method. The physicochemical characteristics, drug release behaviour, antimicrobial properties and biocompatibility of GelMA, PVA NP‐coated GelMA, and GEN@PVA NP‐coated GelMA patches are investigated. Morphological analyses confirmed that 3D‐printed GelMA patches are fabricated in desired sizes and geometries and successfully coated with NPs. In vitro antibacterial tests revealed that GEN@PVA NP‐coated GelMA patches have antibacterial activities against Staphylococcus aureus and Escherichia coli. Moreover, in vitro cell culture studies indicated that all GelMA‐based patches have no cytotoxic effect on L929 mouse fibroblast cells. Considering all, these specially designed biofunctional 3D‐printed GelMA patches can be an effective therapeutic approach for repairing TM perforations.

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Effects of Polyvinyl Alcohol on Drug Release from Nanocomposite Particles Using Poly (L-lactide-<i>co</i>-glycolide)

Cited by 8 publications

References 33 publications

Gentiopicroside PLGA Nanospheres: Fabrication, in vitro Characterization, Antimicrobial Action, and in vivo Effect for Enhancing Wound Healing in Diabetic Rats

Gentiopicroside PLGA Nanospheres: Fabrication, in vitro Characterization, Antimicrobial Action, and in vivo Effect for Enhancing Wound Healing in Diabetic Rats

Prolonging effect of polyvinyl alcohol on the drug release

Development of Specially Designed Nanoparticle‐coated 3D‐printed Gelatin Methacryloyl Patches for Potential Tissue Engineering Applications

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