Effects of pomegranate seed oil on metabolic state of patients with Type 2 diabetes mellitus

Abstract

Background:Rapid increasing prevalence of diabetes mellitus is a serious health concern in the world. New data determined that the pathogenesis of diabetes mellitus is chronic low-grade inflammation, resulting insulin resistance. Pomegranate seed oil (PSO) has anti-inflammatory effects; though it may reduce insulin resistance and improve glycemia in diabetes mellitus. The present study has been designed to investigate the effects of PSO as a natural dietary component on metabolic state of patients with Type 2 diabetes mellitus.Methods:In a randomized double-blind clinical trial study, 80 patients (28 men) with Type 2 diabetes were randomly allocated to the intervention and control groups. The intervention group consumed PSO capsules, containing 1000 mg PSO twice daily (2000 mg PSO), whereas controls take placebo for 8 weeks. The participants followed their previous dietary patterns and medication use. Dietary factors and metabolic factors including lipid profile, fasting plasma sugar, and insulin and were assayed at the baseline and after 8 weeks.Results:Participants in two intervention and control group were similar regarding anthropometric and the dietary factors at baseline and after trial (P > 0.05). Mean level of total cholesterol, triglyceride, low-density lipoprotein-cholesterol, and high-density lipoprotein was not different significantly between groups after trial (P > 0.05). Consumption of PSO did not significantly affect the levels of parameters such as fasting blood sugar (FBS), insulin, HbA1c, alanine transferase, and homeostasis model assessment-insulin resistance.Conclusions:Consumption of 2000mg PSO per day for 8 weeks had no effect on FBS, insulin resistance and lipid profile in diabetic patients.

Lack of efficacy of pomegranate supplementation for glucose management, insulin levels and sensitivity: evidence from a systematic review and meta-analysis

“…The total number of subjects included in each study ranged from 14 to 74 subjects. Among the included studies, fifteen studies reported the FBG outcome [ 27 , 28 , 30 – 32 , 39 – 46 ], 8 reported FBI values [ 29 – 31 , 41 – 43 , 45 , 46 ], 3 reported HbA1c [ 27 , 41 , 43 ] and 7 reported HOMA-IR [ 29 , 31 , 41 – 43 , 45 , 46 ]. The mean age of participants in each trial ranged from 30 to 70 years, with differing age ranges in most studies.…”

“…The mean age of participants in each trial ranged from 30 to 70 years, with differing age ranges in most studies. Of the 16 trials included in the current meta-analysis, 11 studies used pomegranate juice as a supplement (the dosage ranged from 120 to 500 ml/day) [ 27 , 28 , 30 – 32 , 40 , 41 , 44 – 46 ], 2 studies used pomegranate seed oil as treatments (the dosage ranged from 400 to 2000 mg/day) [ 29 , 43 ], and 3 studies utilized pomegranate extract as the intervention (the dosage ranged from 710 to 1420 mg/day) [ 39 , 42 ]. The duration of the pomegranate intervention varied from 1 to 12 week (median: 5.5 week).…”

Effects of green coffee extract on fasting blood glucose, insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR): a systematic review and meta-analysis of interventional studies

“…Diabetes mellitus has now reached an epidemic level in both developing and developed countries. Due to the pandemic level and macro- and micro-vascular complications caused by diabetes mellitus, it could emerge as a worldwide issue with huge economic and social costs [1]. Dietary approaches can be a successful strategy to diminish the risk of diabetic complications [2].…”

Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus

“…Increased free fatty acid flux secondary to insulin resistance and increased proinflammatory adipokines and cytokines from enlarged adipose tissue may be the underlying determinants of this interrelationship. [ 7 8 ]…”