Effects of pomegranate supplement on menopausal symptoms and quality of life in menopausal women: A double-blind randomized placebo-controlled trial

Mehraban, Mohammad Sadegh Adel; Tansaz, Mojgan; Mohammadi, Mohammad; Yavari, Maryam

doi:10.1016/j.ctcp.2022.101544

Cited by 9 publications

(16 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treatment duration ranged between 4 and 12 weeks, and different formulations such as hydroalcoholic extracts (H.-J. Kim et al, 2010), ethanolic extract (Handayani et al, 2017), juice (Adel-Mehraban et al, 2022), powder (Joshi, 2016), andoil (Al-Jeborry &Ameen, 2017;Auerbach et al, 2012;Huber et al, 2017) from different parts of the fruit were used in various doses. Some of these studies have concentrated on P. granatum effects on MSs particularly, but there are also some studies that evaluated the benefits of pomegranate on other aspects of health such as some biochemicals and cardiovascular parameters.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…According to our results, six studies have been performed to evaluate P. granatum supplements on the frequency or severity of MSs. Four of them were RCT (Adel-Mehraban et al, 2022;Auerbach et al, 2012;Joshi, 2016;, one was a pre-post study (Al-Jeborry & Ameen, 2017), and one was an individually controlled study (Huber et al, 2017). Different parts of pomegranate (seed oil: 3 articles; extract: 2 articles; and concentrated pomegranate juice: 1 article) have been used in these studies and different methods were used for the evaluation of MSs.…”

Section: Quantitative Analysismentioning

confidence: 99%

“…Different parts of pomegranate (seed oil: 3 articles; extract: 2 articles; and concentrated pomegranate juice: 1 article) have been used in these studies and different methods were used for the evaluation of MSs. Two studies in the literature used Kupperman index questionnaire (Adel-Mehraban et al, 2022;, 3 used Menopause Rating Scale (MRS) questionnaire (2 RCTs [Auerbach et al, 2012;Joshi, 2016; and the study by Huber et al, 2017 for which individual control group was considered as parallel control group), one study used both Kupperman and MRS (H.-J. Kim et al, 2010), and one study evaluated MSs without any questionnaire (Al-Jeborry & Ameen, 2017), so metaanalysis was performed for MRS scores and 307 people were included.…”

Section: Quantitative Analysismentioning

confidence: 99%

“…Hormone replacement therapy (HRT) has been the primary treatment for MSs, but studies revealed that receiving HRT does not improve the quality of life, and causes a higher incidence rate of breast cancer, CVD, cerebrovascular accident, and pulmonary embolism (Flores et al, 2021). Considering these reasons, many women cannot or choose not to use hormone therapy (Adel-Mehraban et al, 2022). Approximately 51% of women use complementary and alternative medicine (CAM) and more than 60% perceive it to be effective for MSs (Johnson et al, 2019).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Moeini,

Shirafkan,

Gorji

2023

Phytotherapy Research

View full text Add to dashboard Cite

Pomegranate is widely used to preserve human health and help prevent many kinds of diseases. This study aims to review and assess the effects of pomegranate on women's health during and after menopause. PubMed, Web of science, Cochrane, Scopus, and Google Scholar were searched up to the end of 2022 with no language or study type restriction. All types of clinical research studies (randomized clinical trial [RCT], pre–post, case report, and case series) were included. The Cochrane RoB 2.0 tool was used for quality assessment of RCTs. A summary of intervention's effects for each study was provided by calculating standardized mean differences and accompanying 95% confidence interval using random effect model. Weighted mean differences and heterogeneity between studies were assessed using Hedges's method and Cochran's Q test, respectively. Pomegranate can significantly improve hot flashes severity and menopause symptoms and decrease FSH. It significantly improves high‐density lipoprotein but not low‐density lipoprotein, body mass index, and weight. Most of our results are inconclusive, and the small sample sizes and the lack of blinding and randomization have led to an increased risk of bias. Pomegranate can decrease menopause symptoms, but more well‐designed studies, with bigger sample sizes are needed to establish its other clinical benefits for menopausal women.

show abstract

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Quantitative Analysismentioning

confidence: 99%

Section: Quantitative Analysismentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Moeini,

Shirafkan,

Gorji

2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…smooth muscle cells. In females, pomegranate was seen to improve female postmenopausal symptoms(Adel-Mehraban MS, et. al.…”

mentioning

confidence: 99%

Novel Natural Based Chewable Lozenges for the Treatment of Erectile Dysfunction. (c2022)

Frem¹

View full text Add to dashboard Cite

Chewable lozenges are easy to use, and highly flavored oral dosage forms used to deliver active ingredients, while providing high patient compliance rates. This work targets the development of chewable lozenges containing multiple natural active ingredients for the treatment of erectile dysfunction. Five batches were developed and analyzed consecutively by adjusting specific processes and material parameters such as the compounding procedure, and excipient quantities based on the physical appearance, stickiness, texture, chewiness, and taste of the lozenges. The most optimal batch obtained is batch “5” and includes adjustments to the compounding procedure to prepare the gelatin base separately while maintaining a heating temperature of 65-70˚C and a mixing speed of 750 rpm and maintaining a lower temperature of 50-60˚C with a mixing speed of 500 rpm while adding the active ingredients. Adjustments of the total liquid content was made to obtain a volume of 1.55 ml/lozenge and a water content of 0.30 ml/lozenge. In addition, the rotary evaporation technique was implemented to remove 6.7 ml (55.83%) of ethanol from the Black Maca liquid extract. Among other adjustments, these were the most significant in impacting the physical parameters and more specifically the stickiness of the lozenges. This project illustrates the successful development of chewable lozenges as a dosage form for the delivery of multiple active natural ingredients with distinct mechanisms of action. Water and solvent contents like ethanol, and process parameters can impact the physical characteristics of the chewable lozenges.

show abstract

Efficacy of plant‐derived dietary supplements in improving overall menopausal symptoms in women: An updated systematic review and meta‐analysis

Oh,

Park,

Park

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

This updated systematic review and meta‐analysis aims to confirm the effectiveness of plant‐based supplements in improving overall menopausal symptoms and vasomotor symptoms. A systematic review of the literature was conducted by searching the PubMed/MEDLINE, Web of Science, EMBASE, and CENTRAL databases up to June 2022. Randomized placebo‐controlled clinical trials that evaluated the effects of dietary supplements on menopausal symptoms were included. Outcome measures included daily hot flash frequency, Kupperman's index, Menopause Rating Scale, and Greene Climacteric Scale. Pooled data were analyzed using a fixed‐effects model and expressed as a weighted mean difference with a 95% confidence interval for continuous outcomes. For qualitative assessment, 67 studies were selected. For quantitative assessment, 54 reports were obtained from 61 studies. The study participants were peri‐ or postmenopausal women aged 38–85, most of whom experienced hot flashes as a menopausal symptom. The investigational products included 28 soy‐derived, 6 red clover‐derived, and 28 other plant‐derived supplements. Qualitative assessment revealed that approximately 76% of the studies were generally of fair or good quality, whereas 24% were of low quality. Meta‐analysis results indicated significant improvements in all questionnaire scores, including hot flash frequency, in the dietary supplement group compared with the placebo group. Comprehensive evaluation using different questionnaire tools showed that the various plant‐derived dietary supplements can significantly alleviate menopausal symptoms. However, further rigorous studies are needed to determine the association of plant‐derived dietary supplements with menopausal health because of the general suboptimal quality and heterogeneous nature of current evidence.

show abstract

Effects of pomegranate supplement on menopausal symptoms and quality of life in menopausal women: A double-blind randomized placebo-controlled trial

Cited by 9 publications

References 33 publications

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

Novel Natural Based Chewable Lozenges for the Treatment of Erectile Dysfunction. (c2022)

Efficacy of plant‐derived dietary supplements in improving overall menopausal symptoms in women: An updated systematic review and meta‐analysis

Contact Info

Product

Resources

About