Effects of portacaval shunting on hyperdynamic circulation in bile duct-ligated cirrhotic rats

Wong, John H.; Zhang, Yikun; Lee, Samuel S.

doi:10.1016/s0168-8278(97)80054-2

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Since the hepatocellular injury is not a feature of this animal model it has been proposed that oxidative stress originates from the portal circulation and not the diseased liver [ 5 , 9 ]. Furthermore, portacaval shunted rats also develop a hyperdynamic splanchnic circulation related to portosystemic shunting [ 10 - 12 ]. Therefore, in this experimental model the hyperdynamic splanchnic circulation or mesenteric hyperemia could also be associated with intestinal oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Plasma redox status is impaired in the portacaval shunted rat – the risk of the reduced antioxidant ability

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Plasma redox status is impaired in the portacaval shunted rat – the risk of the reduced antioxidant ability

et al. 2008

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“…There are many different models to study cirrhosis, in general, or to study speci c types of human cirrhosis [1,2,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. The carbon tetrachloride model has been developed in both the dog and rat [23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

“…A second model used to induce hepatic cirrhosis in rats and dogs is ligation of the common bile duct [28][29][30][31][32]. Advantages of this technique are that it is technically easy to perform and does not require constant monitoring of the animals during the developmental stage of disease, as do techniques that require toxin administration.…”

Section: Figurementioning

confidence: 99%

A Canine Model of Multiple Portosystemic Shunting

Howe

2000

Journal of Investigative Surgery

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The objective of this study was to develop and describe an experimental canine model of multiple acquired portosystemic shunts (PSS) similar in nature to spontaneously occurring PSS. Sixteen dogs were used and were divided into a control (n = 6) and a diseased group (n = 10). Dogs of the diseased group were administered dimethylnitrosamine (2 mg/kg of body weight, po) twice weekly, and clinicopathologic, ultrasonographic, and hepatic scintigraphic findings were recorded during the development of hepatic disease and PSS. Surgery was then performed to permit visual verification of multiple shunts, catheter placement for portography examination, and biopsy of the liver. All diseased dogs developed severe hepatic disease and multiple PSS as documented visually at surgery and on portography. Based on this study, dimethylnitrosamine-induced portosystemic shunting appears to be an appropriate model for spontaneously occurring multiple PSS secondary to portal hypertension.

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