Effects of Positive End‐Expiratory Pressure on Renal Function

Järnberg, P. O.; Villota, E. Dominguez De; Eklund, Johanna; Granberg, Per‐Ola

doi:10.1111/j.1399-6576.1978.tb01331.x

Cited by 55 publications

(5 citation statements)

References 33 publications

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“…Several studies observed a decrease in cardiac output, renal blood flow, GFR, sodium excretion and urinary flow when increasing ventilatory support [3,5,6,35,36,37]. In contrast to our patients breathing spontaneously with APRV, previous investigations have compared either unsupported spontaneous breathing with positive pressure ventilation [3,5,35] or spontaneous breathing at different CPAP levels [6,36]. Our results are in agreement with those of Steinhoff and coworkers [5,35], who observed improvement in renal function following switching from mechanical ventilation to spontaneous breathing with intermittent mandatory ventilation.…”

Section: Discussionmentioning

confidence: 99%

Effects of spontaneous breathing during airway pressure release ventilation on renal perfusion and function in patients with acute lung injury

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Effects of spontaneous breathing during airway pressure release ventilation on renal perfusion and function in patients with acute lung injury

et al. 2002

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“…Some effects of CPAP on renal function have been documented 49. These include decreased glomerular filtration rate (GFR), reduced urinary sodium excretion, and diminished urinary output 50, 51.…”

Section: Non‐invasive Respiratory Support Modalitiesmentioning

confidence: 99%

Foxn4 influences alveologenesis during lung development

Xiang

2011

Developmental Dynamics

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The terminal stage of lung development begins with the formation of the terminal sacs followed by subdivision of these sacs by septa into numerous alveoli to maximize the gas-exchange surface. This process requires coordinated action of various intrinsic and extrinsic factors as well as interaction of epithelial and mesenchymal cells. We show here that during murine lung development, the Foxn4 transcription factor is expressed in proximal airways by a subpopulation of postmitotic epithelial cells which are distinct from basal and ciliated cells and of which only a small fraction are Clara cells. Targeted inactivation of Foxn4 causes dilated alveoli, thinned alveolar walls, and reduced septa in the distal lung but no overt gross alterations in proximal airways. The alveolar defects in mutants may result from decreased platelet-derived growth factor-A (PDGFA) signaling and reduced surfactant protein B (SFTPB) expression. These data together suggest that Foxn4 may have a non-cell-autonomous role critical for alveologenesis during lung development. Developmental Dynamics 240:1512-1517,

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“…All inhalational anaesthetic agents reduce RBF and GFR in a dependent manner, which highlights the need for careful volume assessment of the patient before and during anaesthesia 63,64 . Mechanical ventilation with positive end‐expiratory pressure (PEEP) exerts an adverse effect on renal function by reducing cardiac preload 65 . The older fluorinated inhalation anaesthetic agents, such as, methoxyflurane were associated with polyuric renal insufficiency, however, the newer agents do not cause this adverse side‐effect.…”

Section: Pathophysiologymentioning

confidence: 99%

Acute renal failure in the surgical setting

Carmichael

2003

ANZ Journal of Surgery

119

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Acute renal failure (ARF) is an unwelcome complication of major surgical procedures that contributes to surgical morbidity and mortality. Acute renal failure associated with surgery may account for 18-47% of all cases of hospital-acquired ARF. The overall incidence of ARF in surgical patients has been estimated at 1.2%, although is higher in at-risk groups. Mortality of patients with ARF remains disturbingly high, ranging from 25% to 90%, despite advances in dialysis and intensive care support. Appreciation of at-risk surgical populations coupled with intensive perioperative care has the capacity to reduce the incidence of ARF and by implication mortality. Developments in understanding the pathophysiology of ARF may eventually result in newer therapeutic strategies to either prevent or accelerate recovery from ARF. At present the best form of treatment is prevention. In this review the epidemiology, pathophysiology, diagnosis, treatment and possible prevention of ARF will be discussed.

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Effects of Positive End‐Expiratory Pressure on Renal Function

Cited by 55 publications

References 33 publications

Effects of spontaneous breathing during airway pressure release ventilation on renal perfusion and function in patients with acute lung injury

Effects of spontaneous breathing during airway pressure release ventilation on renal perfusion and function in patients with acute lung injury

Foxn4 influences alveologenesis during lung development

Acute renal failure in the surgical setting

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