Effects of Post-Surgical Parenteral Nutrition on Patients with Gastric Cancer

Jin, Yanchun; Yong, Chunming; Li, Dan; Yuan, Hao

doi:10.1159/000493410

Cited by 25 publications

(15 citation statements)

References 21 publications

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“…9. Summary and outlook: Improving nutritional support for patients undergoing major gastrointestinal surgery Improved awareness of the adverse impact of poor nutritional status as well as metabolic stress on patients undergoing major gastrointestinal surgery and the benefits of timely and appropriate nutrition support, which include shorter hospital stay, fewer complications and improved patient wellbeing, is warranted [dataset [57,59]]. Implementation of ERAS recommendations for perioperative nutritional support can help to optimize patient outcomes [dataset [34]].…”

Section: Algorithm To Deliver Ppn In the Context Of Erasmentioning

confidence: 99%

Perioperative peripheral parenteral nutrition to support major gastrointestinal surgery: Expert opinion on treating the right patients at the right time

Senkal¹,

Bonavina²,

Reith³

et al. 2021

Clinical Nutrition ESPEN

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Background & aims: Patients undergoing major gastrointestinal surgery may be in particular need of nutritional therapy due to potential pre-existing disease-related malnutrition and the impact of surgical procedures. Peripheral parenteral nutrition (PPN), delivered via a peripheral catheter, is aligned with the Enhanced Recovery After Surgery (ERAS) concept of minimally invasive interventions where possible. However, uncertainties regarding perioperative PPN for patients undergoing major gastrointestinal surgery arise, in part, due to lack of clinical guidelines. This paper aims to provide practical guidance on perioperative PPN, within the framework of ERAS. Methods: A panel of surgeons and nurses convened to identify knowledge gaps and share their best practice experience regarding PPN provision for patients undergoing major gastrointestinal surgery. Clinical needs were identified and addressed based on the panel's experience and a narrative review. Results: Key topics addressed include how PPN can support ERAS nutritional recommendations, identifying gastrointestinal surgery patient subgroups who are likely to benefit from PPN, perioperative timepoints when PPN may be required, and optimizing the delivery of PPN. An algorithm to support the identification and management of patients' perioperative nutritional needs was developed. Conclusions: This paper aims to assist healthcare providers by addressing best practice questions related to the use of PPN during the critical perioperative period within the ERAS concept. This may facilitate timely nutritional intervention to help improve postoperative clinical outcomes and quality of life for patients undergoing major gastrointestinal surgery.

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Section: Algorithm To Deliver Ppn In the Context Of Erasmentioning

confidence: 99%

Perioperative peripheral parenteral nutrition to support major gastrointestinal surgery: Expert opinion on treating the right patients at the right time

Senkal¹,

Bonavina²,

Reith³

et al. 2021

Clinical Nutrition ESPEN

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show abstract

“…Serum PAB is an effective tool for evaluating malnourished patients [ 31 ]. It has been reported that the level of PAB in the study group was significantly higher than that in the control group when parenteral nutrition was given after the gastric cancer surgery [ 32 ]. CER is a kind of ferrous oxidase in mammalian plasma and plays a vital role in the iron metabolism [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis

Guo

Yin

Tan

et al. 2021

Mediators of Inflammation

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Background. Gastrointestinal motility disorder is a common gastrointestinal disease, which seriously affects life quality. Traditional Chinese medicine (TCM) has been widely used as an alternative therapy for gastrointestinal motility disorder. Acacetin is a natural flavonoid compound that has antioxidant and anti-inflammatory, antidepressant, and anticancer properties. However, the efficacy of Acacetin in the treatment of gastrointestinal motility disorders has not been studied. Our aim was to investigate the mechanism of Acacetin-alleviated gastrointestinal motility disorder and its efficacy based on network pharmacology. Methods. We performed network pharmacology to predict the active components, match Weishu decoction (WSD) targets in gastrointestinal motility disorders, and investigate its potential pharmacological mechanisms. We performed the GO and KEGG enrichment analysis. In vivo, we investigated the effects of Acacetin in the gastrointestinal motility disorder model. Results. Based on network pharmacological method, the key active ingredient of WSD was identified as Acacetin, and the enrichment signaling pathway was the PI3K-AKT signaling pathway. Acacetin and Mosapride accelerated gastric emptying time, reduced gastric remnant rate, and increased small intestinal propulsion rate. The levels of GAS and MTL were increased after using Acacetin. These results indicated that Acacetin could improve gastrointestinal motility disorders. Among them, high-dose Acacetin showed a better effect. Acacetin could regulate protein and lipid metabolism in mice with gastrointestinal motility disorder. Furthermore, Acacetin could modulate gastrointestinal inflammation and apoptosis. The detection of the PI3K-AKT signaling pathway-related proteins showed that Acacetin improved gastrointestinal motility disorder by inhibiting the activation of the PI3K-AKT signaling pathway. Conclusion. The key ingredient Acacetin in WSD could alleviate gastrointestinal motility disorder by inhibiting the activation of the PI3K-AKT signaling pathway based on network pharmacology analysis. The efficacy and safety of Acacetin treatment provide strong experimental support for the clinical treatment of gastrointestinal motility disorder.

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“…Parenteral nutrition may be the only option especially for patients who are not suitable for enteral feeding. There are studies suggesting that parenteral nutrition can significantly improve patients' nutritional and psychological status, quality of life and immune functions (17). In addition, a study in an elderly patients undergoing surgery for gastric cancer showed that the combination of enteral and parenteral nutrition is superior to early enteral nutrition or total parenteral nutrition in promoting immune recovery (18).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Preoperative Nutritional Support on Postoperative Morbidity and Mortality in Patients With Gastric Cancer: A Single Center Retrospective Study

Tuncer

Sert²,

Kılınç

et al. 2021

Medical Records

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Weight loss and malnutrition are frequently observed in patients with gastric cancer. Therefore, nutrition is important, especially in patients with gastric cancer. In this study, we aimed to identify the effect of preoperative nutritional support on postoperative morbidity and mortality in patients with gastric cancer. Material and Method: A total of 110 patients underwent gastrectomy due to gastric cancer between December 2015 and December 2019 were retrospectively analyzed. It was determined whether the patients were given preoperative and postoperative nutritional support. Clinicopathological features and short-term results were compared. Results: Overall morbidity was 29.1% (n=32) in patients who underwent gastrectomy. It was observed that the rate of major complications increased statistically with increasing age (p<0.001). Comorbidity was also found to be a risk factor for major complications (OR 3.917, 95% CI 1.423-10.781; p=0.006). The incidence of complications increases especially in patients with a diagnosis of diabetes (OR 3.743, 95% CI 1.201-11.666; p=0.040). While anastomotic leak developed in 6.7% (n=2) of the patients who were taken preoperative nutrition, anastomotic leak developed in 10% (n=8) of the patients who were not taken nutritional support (p=0.588). Likewise, the relationship between the postoperative length of stay, postoperative complications and mortality of patients receiving preoperative nutritional support could not been proven. Conclusion:The present study reveals that preoperative nutrition in patients with gastric cancer was not associated with improved morbidity and mortality rates. Large, multicenter prospective studies focusing on preoperative nutritional support are needed to uncover the exact relation of preoperative nutrition and morbidity-mortality rates in patients with gastric cancer.

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Effects of Post-Surgical Parenteral Nutrition on Patients with Gastric Cancer

Cited by 25 publications

References 21 publications

Perioperative peripheral parenteral nutrition to support major gastrointestinal surgery: Expert opinion on treating the right patients at the right time

Perioperative peripheral parenteral nutrition to support major gastrointestinal surgery: Expert opinion on treating the right patients at the right time

The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis

The Effect of Preoperative Nutritional Support on Postoperative Morbidity and Mortality in Patients With Gastric Cancer: A Single Center Retrospective Study

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