Effects of Posthemorrhagic Ventricular Dilatation in the Preterm Infant on Brain Volumes and White Matter Diffusion Variables at Term-Equivalent Age

Brouwer, Margaretha J.; Vries, Linda S. de; Kersbergen, Karina J.; Aa, Nicolaas E. van der; Brouwer, Annemieke J.; Viergever, Max A.; Išgum, Ivana; Han, Kuo Sen; Groenendaal, Floris; Benders, Manon J. N. L.

doi:10.1016/j.jpeds.2015.09.083

Cited by 55 publications

(46 citation statements)

References 43 publications

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“…Periventricular hemorrhagic dilatation is independently associated with reduced volumes of deep gray matter and the cerebellum, and positively associated with apparent diffusion coefficient in occipital, parieto-occipital and parietal white matter at term-equivalent age. No association was found between IVH grades II-III and brain volumes or apparent diffusion coefficient values, confirming the observations from the study by Brouwer et al [24]. …”

Section: Preterm Brain Injurysupporting

confidence: 90%

The Vulnerable Newborn Brain: Imaging Patterns of Acquired Perinatal Injury

Ferriero¹

2016

Neonatology

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Background: Over the past two decades, imaging techniques have allowed for better visualization of the newborn brain. This has enabled us to detect patterns, understand mechanisms and guide diagnosis and treatment. Objectives: The purpose of this review is to discuss imaging characteristics of acquired perinatal brain injury. Methods: Through literature review and the author's research, this review assesses published data on the distinct imaging patterns that occur in the neonatal period due to acquired brain insults. Results: In the term brain, susceptibility to hypoxia-ischemia, hypoglycemia and hyperbilirubinemia results in unique patterns of injury. Stroke commonly occurs in the newborn period. Infections, especially viral, have distinct patterns of white matter injury. In the preterm brain, white matter injury occurs commonly and is affected by postnatal growth, stress and infection. The cerebellum is uniquely vulnerable during this period, with resultant hemorrhages in almost half of preterm infants. Cerebellar growth is affected by intraventricular hemorrhage, drugs and placental pathology. Periventricular hemorrhagic infarction is the most serious consequence of the spectrum of intraventricular hemorrhage and results in profound disabilities. Conclusions: Taken together, the acquired perinatal brain injuries can have lifelong devastating consequences, so the search for therapies must continue.

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Section: Preterm Brain Injurysupporting

confidence: 90%

The Vulnerable Newborn Brain: Imaging Patterns of Acquired Perinatal Injury

Ferriero¹

2016

Neonatology

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“…VLBW infants with PHVD requiring ventriculoperitoneal shunts have both smaller total brain volumes and larger ventricular volumes than VLBW comparisons [77, 78]. Premature infants with neurodevelopmental impairment have significantly lower baseline MRI volumes of total brain tissue, cerebrum, frontal lobes, basal ganglia and thalami, and cerebellum, and higher ventricular volumes compared to those without impairment [79, 80].…”

Section: Quantitative Mrimentioning

confidence: 99%

“…Gray matter volume on MRI is decreased in the setting of IVH without ventriculomegaly [75] and in PHVD [77]. Deep gray matter growth failure in preterm infants, predominantly affecting lentiform nuclei and thalamic volumes, is more pronounced with white matter lesions [80].…”

Section: Quantitative Mrimentioning

confidence: 99%

“…PHVD is independently associated with decreased volumes of the cerebellum on term equivalent MRI, despite early intervention with shunting [77]. More severe degrees of supratentorial IVH are associated with slower cerebellar growth [33].…”

Section: Quantitative Mrimentioning

confidence: 99%

“…This may correlate with the particular vulnerability of the parieto-occipital region for periventricular white matter injury. Notably, Grades II-III IVH were not associated with increased ADC values in these areas [77]. …”

Section: Quantitative Mrimentioning

confidence: 99%

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Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury

Dorner¹,

Burton

Allen

et al. 2018

J Perinatol

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Intraventricular hemorrhage in the setting of prematurity remains the most common cause of acquired hydrocephalus. Neonates with progressive post-hemorrhagic hydrocephalus are at risk for adverse neurodevelopmental outcomes. The goal of this review is to describe the distinct and often overlapping types of brain injury in the preterm neonate, with a focus on neonatal hydrocephalus, and to connect injury on imaging to neurodevelopmental outcome risk. Head ultrasound and magnetic resonance imaging findings are described separately. The current state of the literature is imprecise and we end the review with recommendations for future radiologic and neurodevelopmental research.

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