Effects of postmenopausal hormone therapy on rheumatoid arthritis: The women's health initiative randomized controlled trials

Walitt, Brian; Pettinger, Mary; Weinstein, Arthur; Katz, James D.; Torner, James C.; Wasko, Mary Chester; Howard, Barbara V.

doi:10.1002/art.23325

Cited by 87 publications

(65 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with this possibility, the incidence of rheumatoid arthritis among women rises in the immediate postmenopausal years, and premature menopause is associated with higher disease risk. Postmenopausal hormone supplementation appears to afford minimal, if any, protection perhaps because IgG glycosylation represents only one of many factors associated with disease risk (39)(40)(41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

Estrogens regulate glycosylation of IgG in women and men

Ercan¹,

Kohrt²,

Cui³

et al. 2017

JCI Insight

107

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Estrogens regulate glycosylation of IgG in women and men

Ercan¹,

Kohrt²,

Cui³

et al. 2017

JCI Insight

107

View full text Add to dashboard Cite

“…Although many studies have shown oral contraceptive pill use to be associated with a lower RA risk, this observation was refuted in a more recent well-designed, prospective investigation [32]. Recent reports similarly found no associations of hormone replacement therapy with RA onset [33,34]. Results of investigations of potential endogenous hormonal factors in RA have also yielded inconsistent results.…”

Section: Reproductive Factorsmentioning

confidence: 90%

Environmental Exposures and Rheumatoid Arthritis Risk

2011

View full text Add to dashboard Cite

In addition to rapidly burgeoning data regarding novel genetic risk factors, a growing list of environmental exposures have been implicated in rheumatoid arthritis (RA) susceptibility. Cigarette smoking is chief among the many environmental exposures implicated in disease risk, accounting for approximately one in six new cases of RA, with recent results underscoring the central importance of select gene-smoking interactions in RA development. In this review, we examine data linking several environmental exposures with RA risk, including cigarette smoking, other air pollutants and occupational exposures, reproductive/hormonal influences, alcohol consumption, select infections leading to periodontal disease, and dietary factors. Where applicable, we review the current understanding of biologic mechanisms linking these environmental factors to disease risk.

show abstract

“…Accumulating evidences showed that sex hormones are implicated in the immune response, and antibody production to antigenic stimulation is greater in women than in men [42,43] . Although conflicting results were reported in the effects of hormone therapy on RA, some clinical trial showed that hormone-containing estradiol has a beneficial effect on disease activity, inflammation and progression of radiological joint destruction [44,45] . Consistent with the findings of previous reports on EORA patients [9,34] , we showed a higher proportion of men and a lower frequency of RF positivity in EORA patients when compared with YORA patients.…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory Cytokine Profiles of Patients with Elderly-Onset Rheumatoid Arthritis: A Comparison with Younger-Onset Disease

et al. 2008

View full text Add to dashboard Cite

Background: Little is known about the differences in the immunopathogenesis between elderly-onset rheumatoid arthritis (EORA) and younger-onset RA (YORA) and the factors responsible for their clinical characteristics. Objective: It was the aim of this study to investigate proinflammatory cytokines of EORA patients and compare them with those of YORA patients. Methods: Serum levels of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α and interferon (IFN)-γ were determined by cytometric bead array in 86 patients with active EORA, in 76 patients with active YORA and in 30 healthy controls. Disease activity of RA was assessed using the 28-joint disease activity score. Erosion scores were recorded using a modified version of the Sharp method. Levels of anti-cyclic citrullinated peptide antibodies were determined by ELISA, and levels of rheumatoid factor-IgM and C-reactive protein were measured by nephelometry. Results: A higher proportion of men and a higher frequency of acute onset with constitutional symptoms and comorbidities were observed in EORA compared with YORA patients. Increased levels of serum IL-1β, IL-6, TNF-α, IFN-γ and IL-8 were positively correlated with the 28-joint disease activity score, and elevated levels of IL-1β and TNF-α were positively correlated with erosion scores for both groups of RA patients. Significantly higher IL-6 levels and lower TNF-α levels were found in EORA compared with YORA patients. Higher levels of serum IL-6 were found in EORA patients with polymyalgia rheumatica-like symptoms than in those without and were also noted in male patients with EORA compared with female patients. Multivariate analysis showed that high levels of TNF-α were associated with the occurrence of constitutional symptoms, and high levels of IL-1β were associated with the presence of anti-cyclic citrullinated peptide antibodies in EORA patients. Conclusion: EORA patients appear to have differences in clinical characteristics and the patterns of proinflammatory cytokines when compared with YORA patients.

show abstract

Effects of postmenopausal hormone therapy on rheumatoid arthritis: The women's health initiative randomized controlled trials

Cited by 87 publications

References 35 publications

Estrogens regulate glycosylation of IgG in women and men

Estrogens regulate glycosylation of IgG in women and men

Environmental Exposures and Rheumatoid Arthritis Risk

Proinflammatory Cytokine Profiles of Patients with Elderly-Onset Rheumatoid Arthritis: A Comparison with Younger-Onset Disease

Contact Info

Product

Resources

About