Effects of praeruptorin C on blood pressure and expression of phospholamban in spontaneously hypertensive rats

Wang, Wenjie; Houqing, Lu; Sun, Li-Ming; Zhong, Ping; Sun, Guibo

doi:10.1016/j.phymed.2013.08.028

Cited by 11 publications

(13 citation statements)

References 12 publications

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“…Praeruptorins are major bioactive pyranocoumarins present in the roots of Peucedanum praeruptorum Dunn and have a wide spectrum of pharmacological properties such as antiinflammatory [3], neuroprotective [33,34], and antihypertensive [5] activities. TPA is a phorbol ester and has been used as a biomedical research tool in cell models of carcinogenesis [35,36].…”

Section: Discussionmentioning

confidence: 99%

“…Peucedanum praeruptorum Dunn (also called Qianhu in Chinese) is a well-known herb in Chinese medicine. It has been widely biological activities, such as anti-inflammatory [3,4], anti-hypertensive [5], and anti-tumor [6,7] activities. Phytochemical research indicated that praeruptorins, a seselin-type coumarin, are one of the main components present in the roots of Peucedanum praeruptorum Dunn, and praeruptorins can be divided into five species: A, B, C, D and E. A recent study reported that praeruptorin A inhibited the p38/AKT/c-Fos/ NAFTc1 pathway and osteoclasts, suggesting that praeruptorin A exerts a protective effect on osteoporosis [8].…”

Section: Introductionmentioning

confidence: 99%

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Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells

Hung

Lee

Chiou

et al. 2019

Cell Physiol Biochem

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells

Hung

Lee

Chiou

et al. 2019

Cell Physiol Biochem

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“…Several studies have revealed that common clinical prescriptions of Chinese medicines, such as Qianhu, Schisandrae, and Salvia miltirrhiza (Wenjie et al, 2014;Ye et al, 2018;Hu et al, 2012), treat hypertension by regulating calcium signaling (Table 3). The hypotensive effects and related mechanisms of MTE, the water-soluble portion of Marsdenia tenacissima, were evaluated by the isometric vessel tension study, and the results suggested that MTE induced vasodilation by reducing calcium influx and promoting endothelial NO release (Hao et al, 2019).…”

Section: Hypertensive Heart Diseasementioning

confidence: 99%

Therapeutic Effects of Traditional Chinese Medicine on Cardiovascular Diseases: the Central Role of Calcium Signaling

Zhang

et al. 2021

Front. Pharmacol.

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Calcium, as a second messenger, plays an important role in the pathogenesis of cardiovascular diseases (CVDs). The malfunction of calcium signaling in endothelial cells and vascular smooth muscle cells promotes hypertension. In cardiomyocytes, calcium overload induces apoptosis, leading to myocardial infarction and arrhythmias. Moreover, the calcium–calcineurin–nuclear factor of activated T cells (NFAT) pathway is essential for expressing the cardiac pro-hypertrophic gene. Heart failure is also characterized by reduced calcium transient amplitude and enhanced sarcoplasmic reticulum (SR) calcium leakage. Traditional Chinese medicine (TCM) has been used to treat CVDs for thousands of years in China. Because of its multicomponent and multitarget characteristics, TCM's unique advantages in CVD treatment are closely related to the modulation of multiple calcium handling proteins and calcium signaling pathways in different types of cells involved in distinct CVDs. Thus, we systematically review the diverse mechanisms of TCM in regulating calcium pathways to treat various types of CVDs, ranging from hypertrophic cardiomyopathy to diabetic heart disease.

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“…Praeruptorins are major bioactive members of pyranocoumarin and can be divided into five species: A, B, C, D, and E. Praeruptorin A (Pra-A) is reported to exert a protective effect on osteoporosis through inhibiting the p38/AKT/c-Fos/NAFTc1 pathway [8]. Pra-C was observed to mitigate cardiac damage and have a clear effect on blood pressure in spontaneously hypertensive rats, suggesting its potential as a novel drug for the treatment and prevention of cardiovascular diseases [9]. One study reported that Pra-B inhibits sterol regulatory element-binding proteins (SREBPs) to improve hyperlipidemia and insulin resistance [10].…”

Section: Introductionmentioning

confidence: 99%

Praeruptorin B Mitigates the Metastatic Ability of Human Renal Carcinoma Cells through Targeting CTSC and CTSV Expression

Lin

Hung

Ying

et al. 2020

IJMS

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Renal cell carcinoma (RCC) is the most common adult kidney cancer, and accounts for 85% of all cases of kidney cancers worldwide. Praeruptorin B (Pra-B) is a bioactive constituent of Peucedanum praeruptorum Dunn and exhibits several pharmacological activities, including potent antitumor effects. However, the anti-RCC effects of Pra-B and their underlying mechanisms are unclear; therefore, we explored the effects of Pra-B on RCC cells in this study. We found that Pra-B nonsignificantly influenced the cell viability of human RCC cell lines 786-O and ACHN at a dose of less than 30 μM for 24 h treatment. Further study revealed that Pra-B potently inhibited the migration and invasion of 786-O and ACHN cells, as well as downregulated the mRNA and protein expression of cathepsin C (CTSC) and cathepsin V (CTSV) of 786-O and ACHN cells. Mechanistically, Pra-B also reduced the protein levels of phospho (p)-epidermal growth factor receptor (EGFR), p-mitogen-activated protein kinase kinase (MEK), and p-extracellular signal-regulated kinases (ERK) in RCC cells. In addition, Pra-B treatment inhibited the effect of EGF on the upregulation of EGFR–MEK–ERK, CTSC and CTSV expression, cellular migration, and invasion of 786-O cells. Our findings are the first to demonstrate that Pra-B can reduce the migration and invasion ability of human RCC cells through suppressing the EGFR-MEK-ERK signaling pathway and subsequently downregulating CTSC and CTSV. This evidence suggests that Pra-B can be developed as an effective antimetastatic agent for the treatment of RCC.

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Effects of praeruptorin C on blood pressure and expression of phospholamban in spontaneously hypertensive rats

Cited by 11 publications

References 12 publications

Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells

Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells

Therapeutic Effects of Traditional Chinese Medicine on Cardiovascular Diseases: the Central Role of Calcium Signaling

Praeruptorin B Mitigates the Metastatic Ability of Human Renal Carcinoma Cells through Targeting CTSC and CTSV Expression

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