Effects of prasugrel pretreatment on angiographic myocardial perfusion parameters in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Abstract

In patients with STEMI undergoing primary PCI, pretreatment with prasugrel resulted in better angiographic perfusion results, as compared with pretreatment with clopidogrel.

Effect of a combination of antiplatelet and antithrombotic pretreatment on myocardial perfusion in patients with an acute ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention

“…Taking these observations into consideration, an effort was made to shorten the time delay to intervention and a search for optimal adjunctive pharmacotherapy that would facilitate the procedure was performed. Different antithrombin and antiplatelet agents have been studied including high doses of intravenous heparin, glycoprotein (Gp) IIb/IIIa inhibitors, oral thienopiridines as well as fibrinolytic agents one at a time or in a combination in an upstream manner or during the procedure [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. They did not show unequivocal evidence in favor of pharmacological pretreatment in STEMI patients undergoing primary PCI: some studies were positive [5,[8][9][10][11][12][13]18], whereas some were not [16,17,20], and in some studies, an excess incidence of bleeding complications was observed among pretreated patients [14,15].…”