Effects of Praziquantel on Eggs of the Asian Tapeworm <i>Bothriocephalus acheilognathi</i>

Kline, S. Jason; Archdeacon, Thomas P.; Bonar, Scott A.

doi:10.1577/a08-038.1

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…Praziquantel (PZQ: 2-cyclohexylcarbonyl-1, 2, 3, 6, 7, 11b-hexahydro-4H-pyrazino [2,1-a] iso-quinoline-4-one) is a broad-spectrum anthelmintic drug used in human and veterinary medicine. In aquaculture, PZQ is mainly used for controlling and killing acanthocephalans (Paterson et al 2013), trematodes (Kim & Cho 2000, Montero et al 2004, Mansell et al 2005, Reimschuessel et al 2011, cestodes (Pool 1985, Kline et al 2009, Iles et al 2012, and other parasites of fish. Although PZQ is applied widely in the treatment of aquatic animals, only a few studies have examined the pharmacokinetics and tissue residues of PZQ in fish (K. Kim et al 2001, C. Kim et al 2003, Tubbs & Tingle 2006a,b, Osman et al 2008, Xie et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus

Dong²,

Yang³

et al. 2016

Dis. Aquat. Org.

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We investigated the pharmacokinetic characteristics of praziquantel (PZQ) in rice field eels Monopterus albus. Pharmacokinetic parameters were determined following a single intravenous administration (5 mg kg −1 body weight [bw]) and a single oral administration (10 mg kg −1 bw) at 22.0 ± 0.7°C. We also evaluated residue depletion in tissues following daily administration of PZQ (10 mg kg −1 bw) that was given orally for 3 consecutive days at 22.0 ± 0.7°C. Following intravenous treatment, the plasma concentration−time curve was best described by a 3-compartment open model, with distribution half-life (t 1/2α ), elimination half-life (t 1/2β ), and area under the concentration−time curve (AUC) of 0.54 h, 17.10 h, and 14505.12 h µg l −1 , respectively. After oral administration, the plasma concentration−time curve was best described by a 1-compartment open model with first-order absorption, with absorption half-life (t 1/2Ka ), elimination halflife (t 1/2Ke ), peak concentration (C max ), time-to-peak concentration (T max ), and AUC estimated to be 2.28 h, 6.66 h, 361.29 µg l , respectively. The oral bioavailability (F ) was 20.9%. With respect to residue depletion of PZQ, the t 1/2β values of muscle, skin, liver, and kidney were 20.2, 28.4, 14.9, and 54.1 h, respectively. Our results indicated rapid absorption, rapid elimination, and low bioavailability of PZQ in rice field eels at the tested dosing conditions.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus

Dong²,

Yang³

et al. 2016

Dis. Aquat. Org.

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“…Another important consideration is whether anthelmintics are ovicidal, that is kill parasite eggs, which is necessary to avoid the discharge of large numbers of eggs to the environment from tapeworms after their treatment (Hoole, 1994;Kline et al, 2009). It is unfortunate that praziquantel and niclosamide are non-ovicidal.…”

Section: Pre Venti On and Controlmentioning

confidence: 99%

Tapeworms as pathogens of fish: A review

Scholz

Kuchta

Oros

2021

Journal of Fish Diseases

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Tapeworms (Cestoda) represents a species rich (about 5000 species) group of flatworms (Neodermata) parasitizing all groups of vertebrates including humans, with about 1000 species parasitizing elasmobranchs and almost 500 occurring in teleosts as adults. They are common parasites of cultured fish, both as adults and larvae (metacestodes), but only few adult tapeworms are actually pathogenic for their fish hosts. In contrast, cestode larvae can be harmful for fish, especially plerocercoids migrating throughout their tissue and internal organs. Current knowledge of hostparasite relationships, including immune response of fish infected with tapeworms, is still insufficient to enable adequate control of cestodoses, and most data available were obtained several decades ago. Treatment of fish infected with adult tapeworms is effective, especially with praziquantel, whereas the treatment of metacestodes is problematic. Control measures include interruption of the complex life cycle and prevention of transport of uninspected fish to new region.

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“…The majority of the research investigating the use of praziquantel to treat cestodes involves fish that are definitive hosts of the invasive Asian tapeworm Bothriocephalus acheilognathi (Table ). Bath treatments were effective for this gastrointestinal parasite, removing 66%–100% of adult parasites from the intestinal lumen (Kline, Archdeacon, & Bonar, ; Mitchell, ; Mitchell & Darwish, ; Pool, Ryder, & Andrews, ; Ward, ). Adults of Khawia sinensis, Atractolytocestus cestus , and Bothriocephalus sp.…”

Section: Efficacy: Cestodesmentioning

confidence: 99%

Use of praziquantel to control platyhelminth parasites of fish

Bader

Starling

Jones

et al. 2018

Vet Pharm & Therapeutics

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Fish are common definitive and intermediate hosts for a variety of parasitic flatworms. In unstressed wild populations, parasitic infections often go unnoticed and are perceived to represent a lesser threat to fish health. In contrast, platyhelminth parasitism of captive fish often results in decreased weight gain and increased mortality which often necessitates chemotherapeutic treatment. The presence of platyhelminth parasites in fish tissues is not only unappealing but in some cases also represents a threat to human health. In veterinary medicine, one of the most commonly used agents with anti‐flatworm activity is praziquantel; yet, no praziquantel products are labeled for use in fish in the United States. Veterinarians may use praziquantel preparations approved for other vertebrate species under the Animal Medicinal Drug Use Clarification Act (AMDUCA). However, such extra‐label use should be informed by scientific evidence including efficacy and tissue residue studies. Herein, we review studies testing the efficacy of praziquantel for treatment of platyhelminthes along with an assessment of routes of administration, pharmacokinetics, and toxicity information.

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Effects of Praziquantel on Eggs of the Asian Tapeworm Bothriocephalus acheilognathi

Cited by 10 publications

References 16 publications

Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus

Pharmacokinetics and residue depletion of praziquantel in rice field eels Monopterus albus

Tapeworms as pathogens of fish: A review

Use of praziquantel to control platyhelminth parasites of fish

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