2007
DOI: 10.1007/s00394-007-0652-0
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Effects of pre- and postnatal protein deprivation on atrial natriuretic peptide- (ANP-) granules of the right auricular cardiocytes

Abstract: It is concluded that ANP-granules are protected from loss even when there is a substantial reduction in body weight and organ size caused by protein deprivation.

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Cited by 12 publications
(12 citation statements)
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“…Through the analysis of the results observed in all articles, it was possible to identify that the casein content used in most studies was 18% for the control group and 9% for the undernourished group. In general, although perinatal protein malnutrition promotes a reduction in the body weight of animals and an absolute reduction of the size of the heart, 14 the relative size of the heart (heart weight/body weight) is higher in animals submitted to protein deficiency in the perinatal period, in both genders. 15 The comparison between the absolute thicknesses of the left ventricle of animals whose mothers received a normoproteic and a hypoproteic diet indicates that malnutrition reduces the ventricular thickness in the animals during the period between the first 24 hours of life until the 8 th week, when there is a significant increase in the thickness of the ventricular wall in malnourished offspring.…”
Section: Discussionmentioning
confidence: 99%
“…Through the analysis of the results observed in all articles, it was possible to identify that the casein content used in most studies was 18% for the control group and 9% for the undernourished group. In general, although perinatal protein malnutrition promotes a reduction in the body weight of animals and an absolute reduction of the size of the heart, 14 the relative size of the heart (heart weight/body weight) is higher in animals submitted to protein deficiency in the perinatal period, in both genders. 15 The comparison between the absolute thicknesses of the left ventricle of animals whose mothers received a normoproteic and a hypoproteic diet indicates that malnutrition reduces the ventricular thickness in the animals during the period between the first 24 hours of life until the 8 th week, when there is a significant increase in the thickness of the ventricular wall in malnourished offspring.…”
Section: Discussionmentioning
confidence: 99%
“…Ten electron micrographs per animal obtained by systematic random sampling of quadrants examined with final magnification of x15, 000 were used to obtain: the number of granules per 96 μm 2 , the area of granules (μm 2 ) and the relative volume (%) of endoplasmic reticulum, mitochondria and Golgi complex [10][11][12][13] (Figure 1). The number of granules present in each field was determined and its area measured using an image analysis program (Axio Vision, Zeiss).…”
Section: Determination Of the Number And Sizes Of Np Granules And Thementioning
confidence: 99%
“…Ratos desnutridos apresentaram severa atrofia dos lóbulos tímicos, com limite córtex-medular muitas vezes indefinido, com a maior presença de timócitos em apoptose (Baptista et al, 2013) e alterações estruturais e ultra-estruturais do complexo polpa-dentina, bem como dos componentes do periodonto de molares (Gonçalves et al, 2015). Todavia, quando a produção do peptídio atrial natiurético (ANP) foi avaliada,verificou-se que a mesma é protegida naqueles animais submetidos à privação protéica, mesmo tendo apresentado uma redução substancial no peso corpóreo e no tamanho do coração (Gama et al, 2007). (Li, et al, 2003).…”
Section: Objetivosunclassified
“…A privação proteica pré e pós-natal determinou alterações nas características histológicas e na atividade da acetilcolinesterase de neurônios do plexo mioentérico do intestino delgado, entretanto, com a recuperação proteica pós-natal, estas foram restauradas (Gomes et al, 2006). O mesmo pode ser admitido em relação aos componentes do plexo mioentérico do esôfago de ratos, onde a privação proteica determinou um atraso na maturação de neurônios mioentéricos, que tiveram a sua morfologia normal quase que completamente restaurada, quando os animais foram renutridos no período pós-natal (Liberti et al, 2007;Greggio et al, 2010). Figura 3-Gaiolas para acondicionamento dos ratos Wistar no biotério do Departamento de Anatomia (ICB/USP).…”
Section: A Desnutrição E O Sistema Nervoso Entéricounclassified
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