Effects of pre- and postnatal exposure to 1880–1900 MHz DECT base radiation on development in the rat

Stasinopoulou, Marianna; Fragopoulou, Adamantia F.; Stamatakis, Antonios; Mantziaras, G.; Skouroliakou, K.; Papassideri, Issidora S.; Stylianopoulou, Fotini; Lai, Henry; Kostomitsopoulos, Nikolaos; Margaritis, Lukas H.

doi:10.1016/j.reprotox.2016.08.008

Cited by 13 publications

(7 citation statements)

References 56 publications

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“…Such neurodevelopment disorders could be due to several RF-induced effects at cellular, biochemical and electrophysiological levels. Indeed, prenatally exposed rodent offspring to RF radiation exhibited apoptosis and neurodegeneration of Purkinje neurons and granule cells in the cerebrellum (Kokturk et al 2013), loss of pyramidal cells and glia fibrilliary acidic protein (GFAP) overexpression in the hippocampus (Stasinopoulou et al 2016), a decrease in neuronal excitability of Purkinje neurons (Haghani et al 2013) and an impairment of glutamatergic synaptic transmission onto pyramidal cells in the prefrontal cortex (Aldad et al 2012). Furthermore, in vitro investigation showed that RF exposure inhibited neurite outgrowth in embryonic neural stem cells differentiated neurons (Chen et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices

Othman

Ammari

Rtibi

et al. 2017

Environmental Toxicology and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices

Othman

Ammari

Rtibi

et al. 2017

Environmental Toxicology and Pharmacology

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“…As mice were freely moving, they experienced the aforementioned range of E‐field values (4.3–17.5 V/m), and consequently, in our situation, brain SAR ranged from 0.022 to 0.366 W/kg and SAE ranged from 159.24 to 2637.56 J/kg. The worst‐case exposure scenario would be to consider the highest recorded average electric field intensity of 17.5 V/m in the animal cage and that the animals were continuously sitting at the position of the highest electric field strength, as also previously described (Stasinopoulou et al., ). Maximum instant electric field strength values recorded in the cage ranged from 50 to 120 V/m, but according to the ICRNIPR guidelines, the calculation of SAR by definition requires the E‐field average value.…”

Section: Methodsmentioning

confidence: 99%

Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study

et al. 2018

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BackgroundThe widespread use of wireless devices during the last decades is raising concerns about adverse health effects of the radiofrequency electromagnetic radiation (RF‐EMR) emitted from these devices. Recent research is focusing on unraveling the underlying mechanisms of RF‐EMR and potential cellular targets. The “omics” high‐throughput approaches are powerful tools to investigate the global effects of RF‐EMR on cellular physiology.MethodsIn this work, C57BL/6 adult male mice were whole‐body exposed (nE xp = 8) for 2 hr to GSM 1800 MHz mobile phone radiation at an average electric field intensity range of 4.3–17.5 V/m or sham‐exposed (nSE = 8), and the RF‐EMR effects on the hippocampal lipidome and transcriptome profiles were assessed 6 hr later.ResultsThe data analysis of the phospholipid fatty acid residues revealed that the levels of four fatty acids [16:0, 16:1 (6c + 7c), 18:1 9c, eicosapentaenoic acid omega‐3 (EPA, 20:5 ω3)] and the two fatty acid sums of saturated and monounsaturated fatty acids (SFA and MUFA) were significantly altered (p < 0.05) in the exposed group. The observed changes indicate a membrane remodeling response of the tissue phospholipids after nonionizing radiation exposure, reducing SFA and EPA, while increasing MUFA residues. The microarray data analysis demonstrated that the expression of 178 genes changed significantly (p < 0.05) between the two groups, revealing an impact on genes involved in critical biological processes, such as cell cycle, DNA replication and repair, cell death, cell signaling, nervous system development and function, immune system response, lipid metabolism, and carcinogenesis.ConclusionsThis study provides preliminary evidence that mobile phone radiation induces hippocampal lipidome and transcriptome changes that may explain the brain proteome changes and memory deficits previously shown by our group.

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“…All experiments were performed in accordance with the approved guidelines and the Greek Presidential Decree 56/2013, which harmonizes national legislation with the European Community Directive 63/2010 on the Protection of Animals Used for Scientific Purposes. Wistar rats were whole-body exposed during prenatal only, or pre- and post-natal life (up to one month postnatally) for 12 h/day (intermittently; half an hour ON and half an hour OFF), to DECT-based radiofrequency electromagnetic radiation (RF-EMR) at 3.7 V/m average electric field intensity, as previously described [43]. No mortality was detected.…”

Section: Methodsmentioning

confidence: 99%

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses

Souli

Klonos

Fragopoulou

et al. 2017

IJMS

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The dielectric properties of biological tissues can contribute non-invasively to a better characterization and understanding of the structural properties and physiology of living organisms. The question we asked, is whether these induced changes are effected by an endogenous or exogenous cellular stress, and can they be detected non-invasively in the form of a dielectric response, e.g., an AC conductivity switch in the broadband frequency spectrum. This study constitutes the first methodological approach for the detection of environmental stress-induced damage in mammalian tissues by the means of broadband dielectric spectroscopy (BDS) at the frequencies of 1–106 Hz. Firstly, we used non-ionizing (NIR) and ionizing radiation (IR) as a typical environmental stress. Specifically, rats were exposed to either digital enhanced cordless telecommunication (DECT) radio frequency electromagnetic radiation or to γ-radiation, respectively. The other type of stress, characterized usually by high genomic instability, was the pathophysiological state of human cancer (lung and prostate). Analyzing the results of isothermal dielectric measurements provided information on the tissues’ water fraction. In most cases, our methodology proved sufficient in detecting structural changes, especially in the case of IR and malignancy. Useful specific dielectric response patterns are detected and correlated with each type of stress. Our results point towards the development of a dielectric-based methodology for better understanding and, in a relatively invasive way, the biological and structural changes effected by radiation and developing lung or prostate cancer often associated with genomic instability.

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Effects of pre- and postnatal exposure to 1880–1900 MHz DECT base radiation on development in the rat

Cited by 13 publications

References 56 publications

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices

Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses

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