Effects of pre-eclampsia on HDL-mediated cholesterol efflux capacity after pregnancy

Kockx, Maaike; Roberts, Lynne M.; Wang, Jeffrey; Tran, Collin; Brown, Mark; Kritharides, Leonard

doi:10.1016/j.athplu.2022.01.003

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Likewise, in a cohort of white European women, women with preeclampsia (31 ± 6.5 y, n = 17) and their fetuses had lower ABCA1-mediated CEC compared with healthy normotensive pregnant women (28.2 ± 7.2 y, n = 17), but there were no differences in the concentration of maternal HDL-C between the two groups [91]. In a separate cohort, women with preeclampsia during pregnancy (31.4 ± 4.8, n = 42) had reduced ABCA1-mediated CEC at 6 months postpartum compared with postpartum women (32.4 ± 4.7 y, n = 44) who were normotensive during pregnancy, but, again, there were no differences in HDL-C concentration among the two groups [92]. The disturbance in HDL function during preeclampsia supports the importance of functional HDL on pregnancy outcomes.…”

Section: Hdl and Adverse Outcomesmentioning

confidence: 81%

HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age

Hong,

Zheng,

Zivkovic

2023

IJMS

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The function of high-density lipoprotein (HDL) particles has emerged as a promising therapeutic target and the measurement of HDL function is a promising diagnostic across several disease states. The vast majority of research on HDL functional biology has focused on adult participants with underlying chronic diseases, whereas limited research has investigated the role of HDL in childhood, pregnancy, and old age. Yet, it is apparent that functional HDL is essential at all life stages for maintaining health. In this review, we discuss current data regarding the role of HDL during childhood, pregnancy and in the elderly, how disturbances in HDL may lead to adverse health outcomes, and knowledge gaps in the role of HDL across these life stages.

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Section: Hdl and Adverse Outcomesmentioning

confidence: 81%

HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age

Hong,

Zheng,

Zivkovic

2023

IJMS

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Exploration of HDL-ome During Pregnancy: A Way to Improve Maternal and Child Health

Zeljkovic,

Stefanovic,

Vekic

2024

Integrated Science

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Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort

Stadler

Poppel²,

Christoffersen³

et al. 2022

Antioxidants

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Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI ≥ 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at <20 weeks, at 24–28 and 35–37 weeks of gestation. Venous cord blood was collected immediately after birth. Maternal and cord blood were used to determine functional parameters of HDL, such as HDL cholesterol efflux capacity, activity of the vaso-protective HDL-associated enzyme paraoxonase-1, and levels of the HDL-associated anti-inflammatory apolipoprotein (apo)M. In addition, we determined serum anti-oxidative capacity. Thirteen percent of the women were diagnosed with GHTN. While we found no changes in measures of HDL function in mothers with GHTN, we observed impaired HDL cholesterol efflux capacity and paraoxonase-1 activity in cord blood, while serum antioxidant capacity was increased. Of particular interest, increased maternal paraoxonase-1 activity and apoM levels in early pregnancy were associated with the risk of developing GHTN. GHTN significantly impairs HDL cholesterol efflux capacity as well as HDL PON1 activity in cord blood and could affect vascular health in offspring. Maternal paraoxonase-1 activity and apoM levels in early pregnancy associate with the risk of developing GHTN.

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Effects of pre-eclampsia on HDL-mediated cholesterol efflux capacity after pregnancy

Cited by 3 publications

References 52 publications

HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age

HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age

Exploration of HDL-ome During Pregnancy: A Way to Improve Maternal and Child Health

Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort

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