Effects of Pregabalin on Subjective Sleep Disturbance Symptoms during Withdrawal from Long-Term Benzodiazepine Use

Rubio, Gabriel; Bobes, Julio; Cervera, G.; Terán, Antonio; Pérez, María; López-Gómez, V.; Rejas, Javier

doi:10.1159/000324850

Cited by 16 publications

(7 citation statements)

References 56 publications

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“…Almost half the respondents were using benzodiazepines. Gabapentinoids have been shown to improve the impairment in sleep quality brought on by problematic benzodiazepine and alcohol use [23,24]. Although not directly referred to by the respondents, this effect may contribute to gabapentinoid abuse within this population, and warrants further study.…”

Section: Discussionmentioning

confidence: 99%

Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers

2013

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Background/Aims: There is emerging evidence of gabapentin and pregabalin (gabapentinoid) abuse, particularly in the substance misuse population, and some suggestion of gabapentinoids being abused alongside methadone. Methods: A questionnaire-based survey was carried out in six substance misuse clinics, looking for evidence of gabapentinoid abuse. Results: 22% (29/129) of respondents admitted to abusing gabapentinoids, and of these, 38% (11/29) abused gabapentinoids in order to potentiate the ‘high' they obtained from methadone. Conclusions: Gabapentinoid abuse along with methadone has not previously been described. These findings are of relevance to clinicians working within both substance misuse services and chronic pain services.

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Section: Discussionmentioning

confidence: 99%

Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers

2013

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“…Pregabalin efficacy did not depend on the benzodiazepine that was being discontinued, or the presence of substance use disorders including opioid- and alcohol-related disorders. In a secondary analysis of the same study, pregabalin treatment led to a 55% improvement in sleep quality at study endpoint, and also improvements in sleep disturbance, snoring, shortness of breath, sleep adequacy, sleep quantity, and daytime somnolence [36]. …”

Section: Benzodiazepine and Zolpidem Withdrawal Symptomsmentioning

confidence: 99%

Pregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review

et al. 2016

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Treatments for physical dependence and associated withdrawal symptoms following the abrupt discontinuation of prescription drugs (such as opioids and benzodiazepines), nicotine, alcohol, and cannabinoids are available, but there is still a need for new and more effective therapies. This review examines evidence supporting the potential use of pregabalin, an α2δ voltage-gated calcium channel subunit ligand, for the treatment of physical dependence and associated withdrawal symptoms. A literature search of the MEDLINE and Cochrane Library databases up to and including 11 December 2015 was conducted. The search term used was ‘(dependence OR withdrawal) AND pregabalin’. No other date limits were set and no language restrictions were applied. Works cited in identified articles were cross-referenced and personal archives of references also searched. Articles were included based on the expert opinions of the authors. There is limited evidence supporting the role of pregabalin for the treatment of physical dependence and accompanying withdrawal symptoms associated with opioids, benzodiazepines, nicotine, cannabinoids, and alcohol, although data from randomized controlled studies are sparse. However, the current evidence is promising and provides a platform for future studies, including appropriate randomized, placebo- and/or comparator-controlled studies, to further explore the efficacy and safety of pregabalin for the treatment of withdrawal symptoms. Given the potential for pregabalin misuse or abuse, particularly in individuals with a previous history of substance abuse, clinicians should exercise caution when using pregabalin in this patient population.

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“…The effect of PGN on overall sleep problems was similar regardless of the BZD abused. The authors concluded that the mechanism that could be underlying the improvement in sleep measures associated to PGN could be related to its efficacy in improving anxiety symptoms [69]. PGN's tolerability was considered excellent or good in most subjects.…”

Section: Pregabalin: Pregabalin (Pgn) (S)-3-(aminomethyl)-5-methyl-mentioning

confidence: 99%

Anticonvulsant Agents for the Management of Benzodiazepine Dependence

Marín-Mayor¹,

López‐Muñoz²,

Rubio³

2014

AAD

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IntroductionChronic use of Benzodiazepines (BZDs) can lead to tolerance and dependence, as indicated by a BZD Withdrawal Syndrome (BWS). In general, it is preferred a gradual than an abrupt tapering of BZDs as a first step in the treatment of BZD Dependence (BD). In addition, a great variety of agents have been used as adjuvant medication for BD. Recently, research has focused in the use of Anticonvulsant (AC) drugs. The aim of this article is to review the use of AC in the management of BWS and BD. MethodsMEDLINE and the Cochrane were searched, selecting studies from 1980 until 2014, in which a pharmacological intervention with classic and new AC was made for discontinuing long-term BZD use. ResultsIn regard to classic AC, there were identified 10 studies related to carbamazepine and 4 studies related to valproate. On one hand, whereas there is a great body of research involving carbamazepine and there is a consensus about its efficacy for discontinuing long-term BZD use, especially in terms of improving drug-free outcomes, there have been brought inconclusive results in regard to valproate. On the other hand, studies identified of the new AC are as follows: 2 for gabapentin, 2 for oxcarbazepine, 2 for pregabalin, 1 for tigabine and 2 for topiramate. With the exception of pregabalin, only small studies and cases report have been conducted for most of the new AC. Pregabalin has demonstrated to be effective in the treatment of BD and BWS, exerting its beneficial action by reducing the severity of withdrawal and anxiety symptoms. ConclusionTo date, among AC agents, only carbamazepine and pregabalin can be considered as augmentation alternatives for the treatment of long-term BZD use. Further randomized, double-blind, placebo-controlled studies are necessary to increase the knowledge to support the use of AC for the treatment of BD and BWS.

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Effects of Pregabalin on Subjective Sleep Disturbance Symptoms during Withdrawal from Long-Term Benzodiazepine Use

Cited by 16 publications

References 56 publications

Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers

Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers

Pregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review

Anticonvulsant Agents for the Management of Benzodiazepine Dependence

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