Effects of prenatal exposure to silver nanoparticles on spatial cognition and hippocampal neurodevelopment in rats

Wu, Jinjin; Yu, Chenghao; Tan, Ying; Hou, Zhen; Li, Man; Shao, Feng; Lu, Xiaofan

doi:10.1016/j.envres.2015.01.022

Cited by 62 publications

(44 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Silver has been shown to cross the blood brain barrier as well as the cerebrospinal fluid barrier to enter tissues of the central nervous system in animals (Lansdown 2007). Following oral AgNP administration in pregnant rats, silver was found to reach the offspring's brain (Lale Ataei and Ebrahimzadeh-bideskan 2014, Lee, et al 2012, Wu, et al 2015). After prenatal exposure to AgNP, silver was detected in hippocampus tissues of offspring, as was cell apoptosis (Lale Ataei and Ebrahimzadeh-bideskan 2014).…”

Section: Introductionmentioning

confidence: 99%

“…That prenatal exposure to AgNP can induce apoptosis in the brains of newborn rats, was confirmed by the findings of elevated expression of the apoptosis mediator, procaspase-3 (Ganjuri, et al 2015). Also, the growth-associated protein-43 (GAP-43) a neuron-specific phosphoprotein that plays a major role in initial development and remodeling of neural connections, was found in significant lower levels in the hippocampus of rat offspring following prenatal exposure to AgNP compared to controls (Wu, et al 2015). Wu and colleagues also found that offspring at postnatal day 35 performed less well in the Morris Water Maze, suggesting impaired spatial cognition in rat offspring following prenatal exposure (Wu, et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Also, the growth-associated protein-43 (GAP-43) a neuron-specific phosphoprotein that plays a major role in initial development and remodeling of neural connections, was found in significant lower levels in the hippocampus of rat offspring following prenatal exposure to AgNP compared to controls (Wu, et al 2015). Wu and colleagues also found that offspring at postnatal day 35 performed less well in the Morris Water Maze, suggesting impaired spatial cognition in rat offspring following prenatal exposure (Wu, et al 2015). Postnatal neurobehavioral disorders as a resulting from prenatal exposure to AgNP has also been reported in mice (Ghaderi, et al 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine

Fennell

Mortensen

Black

et al. 2016

J of Applied Toxicology

View full text Add to dashboard Cite

Here is presented a comprehensive investigation of the distribution of polyvinylpyrrolidone (PVP)-stabilized AgNP (20 or 110 nm) in pregnant rats after a single injection or oral gavage dose. The biological impacts of AgNP exposure were evaluated by metabolomic analysis, and measurement of biomarkers of cardiovascular injury, oxidative stress, and inflammation. The investigation provided a basic understanding of the distribution, internal dose, persistence, metabolomics, and elimination of AgNP following exposure in pregnant rats. Few investigations have been conducted on the disposition and fate of silver nanoparticles (AgNP) in pregnancy. The distribution of a single dose of polyvinylpyrrolidone (PVP)-stabilized AgNP was investigated in pregnant rats. Two sizes of AgNP, 20 and 110 nm, and silver acetate (AgAc) were used to investigate the role of AgNP diameter and particle dissolution in tissue distribution, internal dose, and persistence. Dams were administered AgNP or AgAc intravenously (i.v.) (1 mg/kg) or by gavage (p.o.) (10 mg/kg), or vehicle alone, on gestation day 18 and euthanized at 24 or 48 h post-exposure. The silver concentration in tissues was measured using inductively-coupled plasma mass spectrometry. The distribution of silver in dams was influenced by route of administration and AgNP size. The highest concentration of silver (μg Ag/g tissue) at 48 h was found in spleen for i.v. administered AgNP, and in lungs for AgAc. At 48 h following p.o. administration of AgNP, the highest concentration was measured in cecum and large intestine, and for AgAc in placenta. Silver was detected in placenta and fetuses for all groups. Markers of cardiovascular injury, oxidative stress marker, cytokines, and chemokines were not significantly elevated in exposed dams compared to vehicle-dosed control. NMR metabolomics analysis of urine indicated that AgNP and AgAc exposure impact the carbohydrate, and amino acid metabolism. This study demonstrates that silver crosses the placenta and is transferred to the fetus regardless of the form of silver.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine

Fennell

Mortensen

Black

et al. 2016

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…Other study showed many pathological changes in the brain structure in chicken embryos treated with platinum nanoparticles NP-Pt, showing a moderate degradation of the cerebellar molecular layer, loss in neural cells in the cerebellum cortex, and astrocytosis [23]. In this study, we observed that AgNPs when administration to pregnant rats at concentration (2, 20mg/kg/B.wt) not have seen mortality in dams, while, other study found that administration of 20 mg silver ion led to the death of more than half pregnant rats in group after 1 ml injection, due to that silver nanoparticle is less toxicity than silver ions [24]. Conversely, a great number of studies have already revealed that after pregnant mice or rats were exposed to some exogenous substances, such as nanoparticles, those substances could be detected in the brain of fetus and then they can disturb the homeostasis of CNS or even induce neuronal death [25].…”

Section: Discussionmentioning

confidence: 55%

Effect of maternal exposure of silver nanoparticles on the histogenesis of cerebellum in post-implantation of albino rats embryos

Ali

Salih

2018

ijs

View full text Add to dashboard Cite

The central nervous system is the most important system and is very sensitive to any accidental infection during ontogenesis; it includes brain and spinal cord. The cerebellum is the second largest part of the brain after cerebrum and it's very sensitive to the abnormal changes during the embryological development. This study was designed to investigate the effect of the maternal exposure of selected concentrations of suspension of nanoparticles on the ontogenesis of the rat cerebellum after embryos implanted in uterus.A total of 60 female pregnant rats were divided in to three groups, each contains 20 females. Group1 (G1) was treated orally with 2mg/kg /body weight (b. wt) of suspension of silver nanoparticles (Ag NPs). While group 2 (G2) was treated with 20mg/kg/b. wt of AgNPs after implantation from 7 th day of pregnancy until delivery at day 21 st, for 15 day. And group3 (G3) was considered as control whose received Distal water (D.W) only. We had selected the following embryonic day for treatment (ED12,15, 18 and 21). The histological results showed a defect in the ontogenesis of the cerebellum cortex layers of embryos, through lack of density of external granular layer, as well as degeneration and dispersion of the glial cells in the internal granular layer of cerebellar cortex, in addition to less distribution of cells in the molecular layer due to the ability of AgNPs to pas the placenta and blood brain barrier (BBB) to the embryo's brain after female exposure to the AgNPs during pregnancy. AgNPs at low concentration 2mg/kg/day and higher concentration 20mg/kg/day can produce many histological toxicity to the embryo's hindbrain and cerebellum when administrated to the dams during pregnancy period. ISSN: 0067-2904Ali and SalihIraqi Journal of Science, 2018, Vol. 59, No.1B, pp: 271-277 IntroductionThe central nervous system (CNS) is a very critical and sensitive system during embryogenesis; it is protected by blood-brain barrier (BBB) which, consequently, hampers the success of current therapies by blocking drugs and other chemical and nanoparticles access to brain [1]. BBB is a layer of endothelial cells very tightly bound to each other (by tight junctions, TJ) that block the transport of drugs and many nanoparticles from blood to brain [2]. The cerebellum is the second largest part of the brain therefore, the cerebellum is an ideal useful model for studying many aspects of neural development, because each stage of development has a distinct morphology and special histological features with different types of cells [3]. The volume of the human cerebellum increases ~10× between 20 and 40 weeks of gestation, with the surface area increasing much more due to the formation of folia and lobules [4], [5].Physiologically, the cerebellum is considered as the key regulator of the central nervous system in the mammals, because it regulates the motor and sensory activities such as attention, balance, languages and some emotional functions like fear and pleasure [6], [7] Because rapid development of nan...

show abstract

“…For instance, Xu et al showed that AgNPs may produce oxidative stress and apoptosis in the developing brain of newborn mice (Fatemi et al, ). Moreover, after exposure to AgNPs in mice, the offspring showed significant neural behaviour changes such as spatial cognition disorders (Wu et al, ). All this evidence implies that AgNPs may have severe toxic effects during neural differentiation and cause genotoxicity in the developmental process.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the developmental neurotoxicity of silver nanoparticles and silver ions with mouse embryonic stem cells in vitro

Yin

Yang

et al. 2018

J of Interdiscip Nanomed

View full text Add to dashboard Cite

The wide applications of silver nanoparticles (AgNPs) have raised many concerns worldwide regarding their safety. The few previous studies on the developmental toxicity of AgNPs have been mostly dependent on animal experiments, which are time‐consuming and costly. The rapid development of stem cell biology provides a new in vitro alternative to live animal assays for developmental toxicity studies. Here, we assessed the developmental neurotoxicity of AgNPs and Ag ions using a mouse embryonic stem cell (mESC) toxicology model. Our results showed that AgNP and Ag ion treatments did not affect mESC viability or cause accumulation of reactive oxygen species, at concentrations below 1 μg/mL. Conversely, AgNPs and Ag ions perturbed mESC global and neural progenitor cell‐specific differentiation processes. In fact, both AgNPs and Ag ions induced the anomalous expression of neural ectoderm marker genes, such as Sox1, Sox3, Map2, NeuroD, Nestin, and Pax6, at concentrations lower than 0.1 μg/mL. Interestingly, AgNP effects manifested at earlier time points as compared with Ag ions. In addition, treatment with Ag ions generated neural progenitor cell abnormal morphology. Overall, our data proved that both AgNPs and Ag ions are toxicants, and their toxic effects are somehow different.

show abstract

Effects of prenatal exposure to silver nanoparticles on spatial cognition and hippocampal neurodevelopment in rats

Cited by 62 publications

References 38 publications

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine

Effect of maternal exposure of silver nanoparticles on the histogenesis of cerebellum in post-implantation of albino rats embryos

Assessment of the developmental neurotoxicity of silver nanoparticles and silver ions with mouse embryonic stem cells in vitro

Contact Info

Product

Resources

About