Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study

Tofail, Fahmida; Persson, Lars‐Åke; Arifeen, Shams El; Hamadani, Jena; Mehrin, Ferdina; Ridout, Deborah; Ekström, Eva Charlotte; Huda, Syed Nazmul; Grantham‐McGregor, Sally

doi:10.1093/ajcn/87.3.704

Cited by 149 publications

(167 citation statements)

References 28 publications

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“…This review found some evidence that multivitamin and mineral supplementation might positively influence certain aspects of brain development in children (Leung et al, 2011). The review included six trials on multiple-micronutrient supplementations conducted in Peru, rural Taiwan, Tanzania (on HIV infected mothers), and in rural China, Indonesia and Bangladesh, where mothers were poorly nourished (Joos et al, 1983;Schmidt et al, 2004;McGrath et al, 2006;Tofail et al, 2008;Li et al, 2009;Caulfield et al, 2010). A very recent randomized controlled trial in Indonesia found that multiple micronutrient supplementation in undernourished pregnant mothers resulted in improved motor development, visual attention and spatial ability in pre-schoolers (Prado et al, 2012).…”

Section: Multivitamin and Mineral Supplementationmentioning

confidence: 99%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Nyaradi¹,

Li²,

Hickling³

et al. 2015

Prenatal and Childhood Nutrition

129

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This review examines the current evidence for a possible connection between nutritional intake (including micronutrients and whole diet) and neurocognitive development in childhood. Earlier studies which have investigated the association between nutrition and cognitive development have focused on individual micronutrients, including omega-3 fatty acids, vitamin B12, folic acid, choline, iron, iodine, and zinc, and single aspects of diet. The research evidence from observational studies suggests that micronutrients may play an important role in the cognitive development of children. However, the results of intervention trials utilizing single micronutrients are inconclusive. More generally, there is evidence that malnutrition can impair cognitive development, whilst breastfeeding appears to be beneficial for cognition. Eating breakfast is also beneficial for cognition. In contrast, there is currently inconclusive evidence regarding the association between obesity and cognition. Since individuals consume combinations of foods, more recently researchers have become interested in the cognitive impact of diet as a composite measure. Only a few studies to date have investigated the associations between dietary patterns and cognitive development. In future research, more well designed intervention trials are needed, with special consideration given to the interactive effects of nutrients.

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Section: Multivitamin and Mineral Supplementationmentioning

confidence: 99%

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Nyaradi¹,

Li²,

Hickling³

et al. 2015

Prenatal and Childhood Nutrition

129

View full text Add to dashboard Cite

show abstract

“…Nine of these (conducted in Bangladesh; Burkina Faso; China; Guinea-Bissau; Lombok, Indonesia; Indramayu, Indonesia; Janakpur, Nepal; Niger; and Pakistan) [5][6][7][8][9][10][11][12][13] used UNIM-MAP (see table 1), and the other three (conducted in Mexico [14]; Sarlahi, Nepal [15]; and Zimbabwe [16]) used other multiple micronutrient supplements. The composition of the supplements used in these trials is summarized in table 1.…”

Section: Studies Includedmentioning

confidence: 99%

Multiple Micronutrient Supplementation during Pregnancy in Low-Income Countries: Review of Methods and Characteristics of Studies Included in the Meta-Analyses

Margetts¹,

Fall²,

Ronsmans³

et al. 2009

Food Nutr Bull

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“…Supplementation benefits on children' s cognition were apparent at 7 months of age but not at 18 or 64 months. 12,13 We therefore combine the groups and treat them as a cohort study for this article. We hypothesized that poverty is associated with cognitive deficits, and parental education, pre-and postnatal growth, and home stimulation would mediate the effects of poverty on cognition.…”

mentioning

confidence: 99%

Cognitive Deficit and Poverty in the First 5 Years of Childhood in Bangladesh

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: More than 200 million children ,5 years old in low-and middle-income countries are not reaching their potential in cognitive development because of factors associated with poverty. WHAT THIS STUDY ADDS:Poverty affects children' s cognition as early as 7 months and continues to increase until 5 years of age. It is mainly mediated by parental education, birth weight, home stimulation throughout the 5 years, and growth in the first 24 months. abstract OBJECTIVE: We aimed to determine the timing and size of the cognitive deficit associated with poverty in the first 5 years of life and to examine the role of parental characteristics, pre-and postnatal growth, and stimulation in the home in Bangladeshi children. We hypothesized that the effect of poverty on cognition begins in infancy and is mainly mediated by these factors. METHODS:We enrolled 2853 singletons, a subsample from a pregnancy supplementation trial in a poor rural area. We assessed mental development at 7, 18, and 64 months; anthropometry at birth, 12, 24, and 64 months; home stimulation at 18 and 64 months; and family' s socioeconomic background. In multiple regression analyses, we examined the effect of poverty at birth on IQ at 64 months and the extent that other factors mediated the effect.RESULTS: A mean cognitive deficit of 0.2 (95% confidence interval -0.4 to -0.02) z scores between the first and fifth wealth quintiles was apparent at 7 months and increased to 1.2 (95% confidence interval -1.3 to -1.0) z scores of IQ by 64 months. Parental education, preand postnatal growth in length, and home stimulation mediated 86% of the effects of poverty on IQ and had independent effects. Growth in the first 2 years had larger effects than later growth. Home stimulation had effects throughout the period.CONCLUSIONS: Effects of poverty on children' s cognition are mostly mediated through parental education, birth size, growth in the first 24 months, and home stimulation in the first 5 years. Pediatrics

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Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study

Abstract: Small benefits from early food and MM supplementation were found in infants of low-BMI but not of high-BMI mothers. However, the benefits were of doubtful functional importance, and longer follow-up is required to determine programmatic implications.

Cited by 149 publications

References 28 publications

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

The Role of Nutrition in Children's Neurocognitive Development, From Pregnancy Through Childhood

Multiple Micronutrient Supplementation during Pregnancy in Low-Income Countries: Review of Methods and Characteristics of Studies Included in the Meta-Analyses

Cognitive Deficit and Poverty in the First 5 Years of Childhood in Bangladesh

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