Effects of Preoperative Enoxaparin on Bleeding after Coronary Artery Bypass Surgery

Ghanem, Moussa Abi; Saliba, Élie; Irani, Jihad

doi:10.12816/0017965

Cited by 2 publications

(2 citation statements)

References 14 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inhibition of coagulation function of heparin was prohibiting the activation of thrombin, factor Xa and other clotting enzymes, the anticoagulant function of heparin deeply depended on antithrombin III, binding it and developing an anticoagulant complex, and the complex could increase the anticoagulant function more than one thousand times. However, it seems LMWH has become more popular and replaced heparin in many clinical indications due to the more predictable pharmacokinetic and pharmacodynamic properties (13,22). These findings were also pro our results that administration of LMWH was prior to heparin regarding bleeding related events.…”

Section: Discussionsupporting

confidence: 79%

Preoperative thromboprophylactic administration of low-molecular-weight-heparin significantly decreased the risk of intraoperative bleeding compared with heparin in patients undergoing video-assisted lobectomy for lung cancer

Alai

Zhu

Li³

et al. 2019

Ann. Transl. Med

View full text Add to dashboard Cite

Background: Due to the threat from venous thromboembolism (VTE) after major thoracic surgery, especially for cancers, guidelines recommend either heparin sodium (unfractionated heparin) or lowmolecular-weight-heparin (LMWH) for those patients at high risk of deep vein thrombosis (DVT). However, risk of bleeding remains a major concern for pre-operative administration of anti-coagulation agents. Therefore, this study aimed to compare the bleeding risk of preoperative administration of LMWH and heparin in patients undergoing video-assisted thoracic surgery (VATS) lobectomy for lung cancer.Methods: A retrospective, single-center study was designed. A total of 130 patients diagnosed with lung cancer were included from August 2016 to January 2018. These patients were divided into two groups. The preoperative administration of heparin group (PH group) had received heparin 5,000 IU, BID (twice a day) both pre-and post-operatively. And the LMWH group (PL group) had received LMWH 4,000 IU, QD (once a day) both pre-and post-operatively. These anticoagulants would not be ceased until patient was discharged or 24-hour postoperative chest drainage volume exceeded 500 mL. Both preoperative and postoperative coagulation parameters including platelet count (PLT), hemoglobin value (HGB), international normalized ratio (INR), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), postoperative drainage parameters and intraoperative bleeding volume were compared. Results: A total of 62 patients were collected in PH group, while 68 patients comprised PL group. Preoperative coagulation parameters, hematologic data and demographic data were comparable. Preoperative duration of two agents (P=0.414), operation time (P=0.155), postoperative HGB (P=0.943), PLT (P=0.244), INR (P=0.469), PT (P=0.651), TT (P=0.407), FIB (P=0.151), drainage duration (P=0.800), duration of heparin and LMWH (P=0.778) were all comparable between the two groups. Compared with PL group, intraoperative bleeding volume (105.11 and 50.26, P<0.001) and postoperative mean drainage volume (251.52 and 216.90 mL, P=0.025) of PH group were significant more. Postoperative APTT (30.17 vs. 28.20 seconds, P=0.022) was significantly longer in PH group. Conclusions: Compared with preoperative administration of heparin, preoperative thromboprophylactic administration of LMWH significantly decreased the risk of intraoperative bleeding in VATS lobectomy. A-Lai et al. Decreased bleeding risk of LMWH

show abstract

Section: Discussionsupporting

confidence: 79%

Preoperative thromboprophylactic administration of low-molecular-weight-heparin significantly decreased the risk of intraoperative bleeding compared with heparin in patients undergoing video-assisted lobectomy for lung cancer

Alai

Zhu

Li³

et al. 2019

Ann. Transl. Med

View full text Add to dashboard Cite

show abstract

“…However, heparin could also bind to cells and plasma proteins, which could lead to side effects of heparin-induced thrombocytopenia and osteoporosis (15). Thus, LMWH, which has more predictable pharmacokinetic and pharmacodynamic properties, has become more popular and replaced heparin in many clinical indications (15,17). Recent studies have compared the thromboprophylaxis efficacy of heparin with that of LMWH and found that LMWH was as effective as heparin for VTE prevention (18,19) and was even superior in PE prevention to heparin (20).…”

Section: Discussionmentioning

confidence: 99%

The safety profile of preoperative administration of heparin for thromboprophylaxis in Chinese patients intended for thoracoscopic major thoracic surgery: a pilot randomized controlled study

Deng¹,

Shi²,

Li³

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

Effects of Preoperative Enoxaparin on Bleeding after Coronary Artery Bypass Surgery

Abstract: de l'énoxaparine reçue en préopératoire sur le saignement après chirurgie de pontage coronarien.

Cited by 2 publications

References 14 publications

Preoperative thromboprophylactic administration of low-molecular-weight-heparin significantly decreased the risk of intraoperative bleeding compared with heparin in patients undergoing video-assisted lobectomy for lung cancer

Preoperative thromboprophylactic administration of low-molecular-weight-heparin significantly decreased the risk of intraoperative bleeding compared with heparin in patients undergoing video-assisted lobectomy for lung cancer

The safety profile of preoperative administration of heparin for thromboprophylaxis in Chinese patients intended for thoracoscopic major thoracic surgery: a pilot randomized controlled study

Contact Info

Product

Resources

About